Many physical phenomena in nature can be described or modeled via a differential equation or a system of differential equations. In this work, we restrict our attention to research a solution of fractional nonlinear generalized Burgers' differential equations. Thereby we find some exact solutions for the nonlinear generalized Burgers' differential equation with a fractional derivative, which has domain as R 2 × R + . Here we use the Lie groups method. After applying the Lie groups to the boundary value problem we get the partial differential equations on the domain R 2 with reduced boundary and initial conditions. Also, we find conservation laws for the nonlinear generalized Burgers' differential equation.They obtained the symmetries, according them conservation laws and some analytical solutions for above equation. Later Abd-el-Malek and Amin in [16] studied the symmetry analysis of the generalized (1+1)-dimensional Burgers differential equation in the formwith boundary and initial conditions u(0, x) −→ ∞, for x > 0, u(t, 0) = γr(t), for t > 0, γ = 0, and lim x→∞ u(t, x) −→ ∞, for t > 0.Some recent studies of Burgers differential equation the reader can see in [17,18]. In this research, we show the applying of Lie group analysis to study (2+1)-dimensional time-fractional generalized Burgers' differential equation with boundary and initially conditions:Email addresses and ORCID numbers: gulistan.iskandarova@istanbulticaret.edu.tr, https://orcid.org/0000-0001-7322-1339 (G. Iskenderoglu), dogank@ticaret.edu.tr, https://orcid.org/0000-0002-3420-7718 (D. Kaya)