Pile foundation is the most important foundation type of long-span bridges, of which the ultimate load-bearing capacity affects the safety and sustainable performance of bridges. When constructing large-span bridges, the bridge site may be close to the adjacent fault zones, which seriously affects the safety and long-term performance of pile foundations, causing the failure and unsustainability of long-span bridges in their life-cycle service life. At present, there are no engineering design rules or methods for assessing the load-bearing capacity of the pile foundation near the fault zones. To study the influence of the fault zone on the loading-bearing capacity and sustainable performance of pile foundations, triaxial compression tests were carried out on the mylonite at the Yanji suspension bridge site near the Xiangfan–Guangji fault zone in Hubei Province. The mechanical properties of mylonite were reflected by the Mohr–Coulomb yield criterion, and a topographic and geological modeling method based on the multi-platform was established. Then, the ABAQUS finite element software was used to study the deformation, stress, failure modes, and sustainable performance of the pile foundation under different bridge load levels, analyze the safety of the pile foundation in the fracture zone, and summarize the ultimate bearing characteristics of the pile foundation. The results show that the whole pile and surrounding rock are basically elastic under the pressure of the designed load, the plastic zone of the pile foundation is mainly concentrated at the pile bottom, and the shear stress concentration zone of the pile is mainly manifested in the joint of the cap and pile and the interface between soft and hard rock. When the load is increased to 4 times the designed load, the stress concentration area of the pile body gradually shifts upward from the pile bottom, and the surrounding rock at the bottom forms an “X-shaped” shear failure zone. After 100 years of operation, the maximum compressive stress of piles reaches 28.6 MPa, which is 120% higher than that at the beginning of the bridge construction, indicating that the sustainable performance of the piles can withstand the effect of the fault zone over the designed service years.