Life events stress and psychosocial factors in men with peptic ulcer disease

Feldman, Mark; Walker, Pamela G.; Green, Janet L.; Weingarden, Kathy

doi:10.1016/0016-5085(86)90189-7

Cited by 121 publications

(57 citation statements)

References 32 publications

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“…This agrees with the findings of Feldman et al [19] and Sjodin et al [23], who reported that their PU patients were significantly more depressed as well as more anxious than were the control subjects.…”

Section: Discussionsupporting

confidence: 93%

“…However, failure to demonstrate excess stress in our PU group does not preclude the possibility that these patients might have reacted differently to stress. This is supported by findings in a recent study of PU patients [19], in which there was no significant difference in the frequency of life events between patients and controls, but the patients perceived more events as threatening and reacted more intensely to them than did the controls.…”

Section: Discussionsupporting

confidence: 82%

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Life Events Stress in Saudi Peptic Ulcer Patients of the Eastern Province

et al. 1991

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 82%

Life Events Stress in Saudi Peptic Ulcer Patients of the Eastern Province

et al. 1991

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“…The same holds true for humans. 5,22 Moreover, classic antidepressants 23,24 and anxiolytics 25,26 significantly reduce stress ulcer formation, perhaps to a greater extent than that seen with traditional therapies such as cimetidine and antacids. 27 Indeed, induction of gastric lesions in rodents by sociopsychological stress is useful as an experimental model to assess the anxiolytic activity of novel drugs and the anxiolytic potency of a drug may be predicted by its anti-ulcer effect.…”

Section: Introductionmentioning

confidence: 99%

Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs

et al. 2002

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When exposed to prolonged stress, rats develop gastric ulceration, enhanced colon motility with depletion of its mucin content and signs of physiological and behavioral arousal. In this model, we tested whether antidepressants (fluoxetine and bupropion), anxiolytics (diazepam and buspirone) or the novel nonpeptide corticotropin-releasing hormone (CRH) type-1 receptor (CRH-R1) antagonist, antalarmin, modify these responses. Fluoxetine, bupropion, diazepam and antalarmin all suppressed stress-induced gastric ulceration in male SpragueDawley rats exposed to four hours of plain immobilization. Antalarmin produced the most pronounced anti-ulcer effect and additionally suppressed the stress-induced colonic hypermotility, mucin depletion, autonomic hyperarousal and struggling behavior. Intraperitoneal CRH administration reproduced the intestinal but not the gastric responses to stress while vagotomy antagonized the stress-induced gastric ulceration but not the intestinal responses. We conclude that brain CRH-R1 and vagal pathways are essential for gastric ulceration to occur in response to stress and that peripheral CRH-R1 mediates colonic hypermotility and mucin depletion in this model. Nonpeptide CRH-R1 antagonists may therefore be prophylactic against stress ulcer in the critically ill and therapeutic for other pathogenetically related gastrointestinal disorders such as peptic ulcer disease and irritable bowel syndrome.

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“…21 Details of these assessments are available in Swedish and the measure has also been used in other studies. 22 The interview was used to produce a stress resilience score from 1 to 9, which we grouped into low (1-3), medium (4-6) and high (7)(8)(9).…”

mentioning

confidence: 99%

“…23 The results of the above four assessments were transformed into a single score with a value on a normalised standard scale, ranging between 1(lowest) -9 (highest). We grouped the scores into low (1-3), medium (4-6) and high (7)(8)(9).…”

mentioning

confidence: 99%