Life history and biochemical effects of chlorantraniliprole on Chironomus riparius

Rodrigues, Andreia C.M.; Gravato, Carlos; Quintaneiro, Carla; Golovko, Oksana; Žlábek, Vladimír; Barata, Carlos; Soares, Amadeu M.V.M.; Pestana, João L.T.

doi:10.1016/j.scitotenv.2014.12.021

Cited by 89 publications

(50 citation statements)

References 40 publications

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“…These observations suggest that glutathione and related enzymes play a major role in the protection of S. vittatum against CAP-induced reactive oxygen species (ROS). In line with our study, a decrease in total glutathione levels and absence of oxidative damage were also observed in C. riparius exposed to CAP [4]. Because glutathione contributes to the maintenance of cellular redox status as it binds to electrophilic compounds and ROS, resulting in less toxic metabolites that are more easily excreted [36], and because the ratio between reduced (GSH) and oxidized glutathione (GSSG) is essential to the maintenance of the oxidative status of cells [37], future research should investigate whether CAP exposure alters the GSH/GSSG ratio.…”

Section: Discussionsupporting

confidence: 92%

“…In addition, CAP exposure did not cause significant alterations in AChE, activity which is not surprising because AChE is not the molecular target of this insecticide [1]. These results are also in good agreement with the lack of CAP-induced effects on AChE activity in C. riparius [4] and to the lack of CAP-induced in vitro effects using S. vittatum larvae [38]. Nevertheless, the study of AChE activity is of interest because these neurotoxic insecticides act on calcium channels that play different vital roles in the regulation of a vast array of cellular processes, including neurotransmitter release [39].…”

Section: Discussionsupporting

confidence: 79%

“…the ephemeropteran Centroptilum triangulifer (LC50 of 11.6 mg/L) [2], and the trichopteran Chimarra atterima (LC50 of 11.7 mg/L) [2]. A higher tolerance to CAP has been reported for the dipteran Chironomus riparius (LC50 of 77.5 mg/L) [4]. This means that caddisfly larvae of S. vittatum are quite sensitive to CAP and because concentrations of CAP in surface waters can reach 9.7 mg/L [3], there is a potential risk for acute detrimental effects in the field.…”

Section: Discussionmentioning

confidence: 99%

“…Feeding behavior has been presented as a reliable, sensitive endpoint to assess chemical-induced stress in freshwater invertebrates [19,47,48]. Furthermore, if complemented with other bioenergetic parameters, such as energy reserves and cellular metabolism, it can be linked to effects on growth, reproduction, and even survival of organisms [7,4,49]. Our results showed that effects of CAP on S. vittatum larvae did not translate into depletion of sugars or lipids, which is usually attributed to the costs of detoxification and/or the consequences of cellular protection mechanisms [4,22,50,51].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, if complemented with other bioenergetic parameters, such as energy reserves and cellular metabolism, it can be linked to effects on growth, reproduction, and even survival of organisms [7,4,49]. Our results showed that effects of CAP on S. vittatum larvae did not translate into depletion of sugars or lipids, which is usually attributed to the costs of detoxification and/or the consequences of cellular protection mechanisms [4,22,50,51]. On the contrary, at the highest CAP concentration tested, a slight increase in lipid content of exposed larvae was observed.…”

Section: Discussionmentioning

confidence: 99%

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Exposure to chlorantraniliprole affects the energy metabolism of the caddisfly Sericostoma vittatum

Rodrigues¹,

Gravato

Quintaneiro

et al. 2016

Enviro Toxic and Chemistry

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Caddisflies have been included in ecotoxicological studies because of their sensitivity and ecological relevance. The present study aimed to assess the sublethal effects of an anthranilic diamide insecticide, chlorantraniliprole (CAP), to Sericostoma vittatum. Used worldwide, CAP is a persistent compound that has been found in surface waters at concentrations from 0.1 μg/L to 9.7 μg/L. It targets the ryanodine receptors, and the present ecotoxicological assessment focused on biomarkers related to neurotransmission, biotransformation, oxidative stress damage, and endpoints related to energy processing (feeding, energy reserves, and cellular metabolism). Six days of exposure trials revealed that feeding activity was significantly decreased in S. vittatum larvae exposed to 0.9 μg/L CAP. Concomitantly, a reduction in cellular metabolism and a significant decrease in protein content were also observed in caddisfly larvae exposed to CAP, suggesting metabolic depression. The results show that sublethal concentrations of CAP can cause detrimental sublethal effects on S. vittatum total glutathione content at concentrations as low as 0.2 μg/L. Bioenergetics can be used to assess physiological effects of contaminants, and the present results show that exposure to low, environmentally relevant, concentrations of CAP alter energy acquisition and metabolism in nontarget aquatic insects with potential population level effects. Environ Toxicol Chem 2017;36:1584-1591. © 2016 SETAC.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Exposure to chlorantraniliprole affects the energy metabolism of the caddisfly Sericostoma vittatum

Rodrigues¹,

Gravato

Quintaneiro

et al. 2016

Enviro Toxic and Chemistry

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FLUID AND ION SECRETION BY MALPIGHIAN TUBULES OF LARVAL CHIRONOMIDS, Chironomus riparius: EFFECTS OF REARING SALINITY, TRANSPORT INHIBITORS, AND SEROTONIN

Zadeh-Tahmasebi

Bui

Donini

2016

Arch Insect Biochem Physiol

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Larvae of Chironomus riparius respond to ion-poor and brackish water (IPW, BW) conditions by activating ion uptake mechanisms in the anal papillae and reducing ion absorption at the rectum, respectively. The role that the Malpighian tubules play in ion and osmoregulation under these conditions is not known in this species. This study examines rates of fluid secretion and major cation composition of secreted fluid from tubules of C. riparius reared in IPW, freshwater (FW) and BW. Fluid secretion of tubules from FW and BW larvae was similar but tubules from IPW larvae secrete fluid at higher rates, are more sensitive to serotonin stimulation, and the secreted fluid contains less Na(+) . Therefore in IPW, tubules work in concert with anal papillae to eliminate excess water while conserving Na(+) in the hemolymph. Tubules do not appear to play a significant role in ion/osmoregulation under BW. Serotonin immunoreactivity in the nervous system and gastrointestinal tract of larval C. riparius was similar to that seen in mosquito larvae with the exception that the hindgut was devoid of staining. Hemolymph serotonin titer was similar in FW and IPW; hence, serotonin is not responsible for the observed high rates of fluid secretion in IPW. Instead, it is suggested that serotonin may work in a synergistic manner with an unidentified hormonal factor in IPW. Ion transport mechanisms in the tubules of C. riparius are pharmacologically similar to those of other insects.

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Mixture Toxicity of Three Unconventional Gas Fracking Chemicals, Barium, O‐Cresol, and Sodium Chloride, to the Freshwater Shrimp Paratya australiensis

Willems

Kumar

Nugegoda

2023

Enviro Toxic and Chemistry

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The 96-h acute toxicity of barium (Ba 2+ ), o-cresol, and sodium chloride (NaCl) to Paratya australiensis was assessed in single, binary, and ternary combinations in addition to three biochemical assays: glutathione S-transferase, acetylcholinesterase, and sodium-potassium adenosine triphosphatase. The 96-h lethal concentrations that expressed 50% mortality (LC50) in the single-toxicant exposures were Ba 2+ = 23.4 mg/L, o-cresol = 12.2 mg/L, and NaCl = 4198 mg/L. Mortality from ocresol exposure occurred between 11 and 22 mg/L, whereas Ba 2+ was more gradual across 10-105 mg/L, and most of the NaCl mortality occurred between 2050 and 4100 mg/L. Toxic units were used to assess the binary and ternary interactions of the toxicants. A more than additive effect was observed for most combinations in the binary chemical exposures, with the ternary combinations yielding highly synergistic interactions. Greater synergism was observed with the 96-h LC50 of o-cresol in combination with the three concentrations of NaCl (1025, 2050, and 3075 mg/L) compared with Ba 2+ , with toxic units of 0.38, 0.48, and 0.10 (o-cresol) and 0.71, 0.67, and 0.50 (Ba 2+ ). No notable enzyme activity trends were observed in the enzyme biomarker responses from both individual and mixture exposures. Although acute single-species toxicity tests tend to underestimate the effects of Ba 2+ , o-cresol, and NaCl on populations, communities, and ecosystems in seminatural (e.g., mesocosms) and natural systems, there are currently no published acute toxicity data available for P. australiensis and the three toxicants used in the present study. The present study shows that chemicals with different toxicity mechanisms can potentially lead to more synergistic responses.

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Life history and biochemical effects of chlorantraniliprole on Chironomus riparius

Cited by 89 publications

References 40 publications

Exposure to chlorantraniliprole affects the energy metabolism of the caddisfly Sericostoma vittatum

Exposure to chlorantraniliprole affects the energy metabolism of the caddisfly Sericostoma vittatum

FLUID AND ION SECRETION BY MALPIGHIAN TUBULES OF LARVAL CHIRONOMIDS, Chironomus riparius: EFFECTS OF REARING SALINITY, TRANSPORT INHIBITORS, AND SEROTONIN

Mixture Toxicity of Three Unconventional Gas Fracking Chemicals, Barium, O‐Cresol, and Sodium Chloride, to the Freshwater Shrimp Paratya australiensis

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