Life’s Essential 8, Life’s Simple 7 and the odds of hyperuricaemia: results from the China Multi-Ethnic Cohort Study

Abstract

Objective Life’s essential 8 (LE8) was a new comprehensive metric and updated based on life’s simple 7 (LS7). Few studies have investigated the association between LE8 and the odds of hyperuricaemia (HUA). To examine the association between LE8, LS7 with odds of HUA. Methods We cross-sectionally analyzed data from the China Multi-Ethnic Cohort (CMEC) study. LE8 and LS7 were categorized as low, moderate and high levels. The CMEC provided an ideal and unique opportunity to characterize the association between LE8, LS7 and the odds of HUA. Results Of the 89,823 participants, 14,562 (16.2%) had HUA. The high level of LE8 was associated with a lower odds of HUA after full adjustment. The adjusted ORs were 1 (reference), 0.70 (95% CI: 0.67–0.73) and 0.45 (0.42–0.48) across low, moderate and high LE8 groups, respectively (P-trend＜0.001). Similar results were observed in LS7 and HUA. The adjusted ORs were 1 (reference), 0.68 (95% CI: 0.65–0.71) and 0.46 (0.43–0.49) across low, moderate and high LS7 groups, respectively (P-trend＜0.001). There were significant interaction between LE8 and age, gender, ethnicity and drinking habits on HUA. Receiver operator characteristic analysis showed that area under the curve (AUC) of LE8 and LS7 were similar (AUCs: 0.638 and 0.635, respectively). Conclusion This study indicated a clearly inverse gradient association between cardiovascular health metrics, termed as LE8 or LS7, with the odds of HUA.