The chapter explores the complex interplay among stress, resilience, and optimal cognitive functioning within the context of leadership. It researches the neuroscience of stress, chronic stress's neurobiological effects, and resilience's buffering function. This chapter examines evidence-based stress management techniques and provides practical strategies for developing resilience. The chapter elucidates the neuroscientific underpinnings that support the notion that resilience influences problem-solving, creativity, and decision-making. Real-world illustrations serve to demonstrate the adept navigation of challenges by resilient leaders. Case studies illustrate the integration of resilience practices by organizations. Furthermore, the text covers practical leadership advice and the overarching concept of organizational resilience concerning neuroleadership.