Life Span of Thrombocytes and Erythrocytes in Normal and Thrombocytopenic Calves

Mizuno, N.; Perman, V.; Bates, F.; Sautter, J. H.; Schultze, Michael

doi:10.1182/blood.v14.6.708.708

Cited by 32 publications

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“…In goats the total number of platelets reported by WILKINS and HODGES (1962) was 421,000. In cattle, the count recorded by MIZUNO et al (1959) was even higher (800,000).…”

Section: Scarboroughmentioning

confidence: 91%

Blood Characteristics of the Adult Donkey*

Nayeri

2010

Zentralblatt Für Veterinärmedizin Reihe A

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Summary Blood characteristics of 50 male and 50 female adult donkeys were examined, as were differences between males and females. Female animals showed higher mean values for total erythrocytes, sedimentation rate, eosinophil, neutrophil and basophil counts, and for lymphocyte, neutrophil, eosinophil and basophil diameters, prothrombin time, serum Ca, glucose, Na and K. Male animals showed higher mean values for Hb concentration, PCV, MCV, MCH, MCHC, erythrocyte and monocyte diameters, total number of leucocyte and platelet, lymphocyte and monocyte counts and serum cholesterol and inorganic phosphate. The differences were significant for Hb, erythrocyte diameter and serum Ca at the 1% level, MCV and serum K at 5% MCH and lymphocyte diameter at 2% and for neutrophil and eosinophil diameters at 0.1% level. Zusammenfassung Das Blutbild des adulten Esels Von je 50 männlichen und weiblichen Eseln wurden die Blutbilder unter besonderer Berücksichtigung der Geschlechtsunterschiede untersucht. Folgende Parameter waren bei den weiblichen Tieren höher: Erythrozytenzahl, Erythrozytensenkungsgeschwindigkeit, Zahl der Eosinophilen, Neutrophilen und Basophilen pro μl, Durchmesser der Lymphozyten, Neutrophilen, Eosinophilen und Basophilen, Prothrombinzeit, Serumkonzentration von Glucose, Ca, Na und K. Folgende Parameter waren bei den männlichen Tieren höher: Hb‐Gehalt, PCV, MCV, MCH, MCHC, Durchmesser der Erythrozyten und Monozyten, Zahl der Leukozyten, Thrombozyten, Lymphozyten und Monozyten pro μl, Serumkonzentration von Cholesterol und anorganischem Phosphat. Die Signifikanz der Differenzen betrug: Hb‐Gehalt, Erythrozytendurchmesser und Ca‐Gehalt: P < 0,01; MCV und K: P < 0,05; MCH und Lymphozytendurchmesser: P < 0,02; Durchmesser der Neutrophilen und Eosinophilen: P < 0,001. Résumé Image sanguine de l'âne adulte On a recherché l'image sanguine chez 50 ânes mâles et 50 ânes femelles en mettant l'accent sur la différence due au sexe. Les paramètres suivants furent plus élevés chez les femelles: le nombre d'érythrocytes, la vitesse de sédimentation des globules rouges, le nombre des éosinophiles, neutrophiles et basophiles par μl, le diamètre des lymphocytes, neutrophiles, éosinophiles et basophiles, le temps de prothrombine, la concentration sérique du glucose, Ca, Na et K. Les paramètres suivants furent plus élevés chez les mâles: le taux d'hémoglobine, PVC, MCV, MCH, MCHC, le diamètre des érythrocytes et des monocytes, le nombre des leucocytes, thrombocytes, lymphocytes et monocytes par μl, la concentration sérique du cholestérol et du phosphate anorganique. Les différences significatives furent les suivantes: taux d'hémoglobine, diamètre des érythrocytes et taux de Ca: P < 0,01; MCV et K: P < 0,05; MCH et diamètre des lymphocytes: P < 0,02; diamètre de neutrophiles et des éosinophiles: P < 0,001. Resumen El cuadro hemático del burro y burra adultos En cada vez 50 burros y burras se analizaron los cuadros hemáticos bajo la consideración especial de las diferencias sexuales. Los parámetros siguientes eran más elevados en la...

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“…In goats the total number of platelets reported by WILKINS and HODGES (1962) was 421,000. In cattle, the count recorded by MIZUNO et al (1959) was even higher (800,000).…”

Section: Scarboroughmentioning

confidence: 91%

Blood Characteristics of the Adult Donkey*

Nayeri

2010

Zentralblatt Für Veterinärmedizin Reihe A

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“…One possible explanation for the observed discrepancy between the 32P-labeled diisopropyl fluorophosphate and 5tCr labeling data is the reported effect of high doses of 32P-labeled diisopropyl fluorophosphate upon platelet behavior in vitro and in vivo (9,26). An alternate explanation may be reutilization of 32P-labeled blood components for the production of new platelets (11,25). This phenomenon accounts for the "tailing" of 52P-labeled platelet survival C e FIG.…”

Section: Discussionmentioning

confidence: 99%

Platelet Kinetics in Canine Ehrlichiosis: Evidence for Increased Platelet Destruction as the Cause of Thrombocytopenia

Smith

Ristić²,

Huxsoll³

et al. 1975

Infect Immun

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A significant (P < 0.025) increase in the mean platelet diameter occurred in five Ehrlichia canis-infected dogs when platelet numbers decreased to 100,0004d1 or less. Maximal incorporation of [75Se ]selenomethionine into platelets of six uninfected dogs was 0.080 + 0.019% (mean + standard error) and occurred 5 to 6 days after dosage, whereas maximal incorporation was 0.036 ± 0.004% within 2 to 3 days after dosage in seven chronically infected dogs that had thrombocytopenia. Analysis of the [75Se ]selenomethionine curves yielded a platelet lifespan of 9 days in uninfected dogs versus 4 days in chronically infected dogs. Thus, megakaryocyte maturation and/or platelet release occurred at an accelerated rate in infected dogs, whereas increased destruction of newly produced labeled platelets diminished their number of peripheral blood. [5'Cr]sodium chromatelabeled platelet survival was exponential, with a half-life of approximately 1 day in two dogs at 2 to 4 days postinfection and three chronically infected dogs. Platelet survival time was 8 days and rectilinear in four uninfected dogs. Platelet recovery was 39.43 i 2.86%7(i in infected dogs as compared with 68.2 + 10.72% in uninfected dogs. Whole-body scans of one dog prior to and 7 days after infection showed that labeled platelets were destroyed primarily in the spleen. It is concluded that the thrombocytopenia in E. canis-infected dogs is the result of' increased platelet destruction which begins within a few days after infection.

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“…Anaemia, thrombocytopenia and neutropenia can be ascribed to depression of normal haematopoietic cells in the bone marrow. Due to the short residence time of granulocytes in peripheral blood and the short life span of thrombocytes (approximately 10 days), it seems reasonable that in the current case thrombocytopenia and neutropenia were severe [ 28 ]. Despite the relatively long lifespan of red blood cells in healthy calves (about 110–120 days), myelophthisis may affect the erythroid lineage of a growing animal with an expanding blood volume more severely than an adult being suffering from acute leukaemia.…”

Section: Discussionmentioning

confidence: 99%

Acute basophilic leukaemia in a three-month-old calf

et al. 2015

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A three-month-old female Holstein–Friesian calf was presented with acute tetraparesis. After neurological examination a multifocal lesion in the central nervous system was suspected with the most pronounced lesions between the third thoracic and the third lumbar vertebrae. Haematological examination revealed moderate anaemia as well as severe thrombocytopenia, neutropenia and leucocytosis. A blood smear and bone marrow aspirate exhibited predominantly blasts with basophilic granulation leading to a diagnosis of acute (myeloid) leukaemia with involvement of the basophilic lineage or an acute basophilic leukaemia. Magnetic resonance imaging revealed spinal cord compression; at necropsy, extensive localised haemorrhages extending into the thoracic vertebral canal were found. Histopathology revealed a large population of blast cells in several tissues including the meninges. Due to multifocal detection of neoplastic cells in the vascular system, neoplasia of the haematopoietic system was assumed in agreement with haematological findings. Signs of paresis could be explained by intramedullary spinal cord haemorrhage and myeloid infiltrations of meningeal vessels. In conclusion, despite its rarity, acute myeloid leukaemia with involvement of the basophilic lineage may be considered in diagnosing calves with progressive deteriorating general condition, paresis, leucocytosis with moderate basophilic differentiation or haemorrhagic disorders.

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Life Span of Thrombocytes and Erythrocytes in Normal and Thrombocytopenic Calves

Cited by 32 publications

References 0 publications

Blood Characteristics of the Adult Donkey*

Blood Characteristics of the Adult Donkey*

Platelet Kinetics in Canine Ehrlichiosis: Evidence for Increased Platelet Destruction as the Cause of Thrombocytopenia

Acute basophilic leukaemia in a three-month-old calf

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