Life spans in mice from strains selected for high or low aggression

Ewalds-Kvist, S. Béatrice M.; Selander, Ritva-Kajsa

doi:10.1002/(sici)1098-2337(1996)22:6<457::aid-ab6>3.0.co;2-e

Cited by 6 publications

(7 citation statements)

References 23 publications

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“…First, longevity varies with personality (Cavigelli and McClintock, 2003;Cavigelli et al, 2009;Ewalds-Kwist and Selander, 1996), suggesting a cumulative cost to personality. In LAL-SAL mice for example, young LAL mice have a higher antioxidant capacity than SAL mice yet their oxidative stress levels are not lower, and ultimately they have shorter life spans (Costantini et al, 2008a;Ewalds-Kwist and Selander, 1996). To achieve the same level of oxidative stress, therefore, young LAL mice may up-regulate their antioxidant system, an additional investment that may be costly in later life (Costantini et al, 2008a).…”

Section: Introductionsupporting

confidence: 76%

“…This pattern of high OXY but equivalent OS has also been observed by Costantini and colleagues (Constantini et al, 2008a) when considering aggression in mice, but at the slow (passive) extreme of that trait. Passive mice also have shorter life spans (Ewalds-Kwist and Selander, 1996) and show greater hormonal stress responsiveness than aggressive mice (Veenema et al, 2003). Unifying these studies, Costantini and colleagues suggest that the higher antioxidant capacity in stress-responsive LAL mice may in fact be a surplus, buffering against short-term, stressinduced increases in pro-oxidant production (Constantini et al, 2008a).…”

Section: Discussionmentioning

confidence: 99%

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Oxidative profile varies with personality in European greenfinches

Herborn

Coffey²,

Larcombe³

et al. 2011

Journal of Experimental Biology

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SUMMARYWhere behavioural responses differ consistently between individuals, this is termed 'personality'. There is the suggestion, but with little supporting data, that personality traits reflect underlying variation in physiology. Here, we tested whether greenfinches Carduelis chloris differing in personality traits differed in various plasma indices of oxidative profile: antioxidant capacity (OXY), pro-oxidant status (reactive oxygen metabolites, ROMs), oxidative stress (OS) and an end-product of oxidative damage: malondialdehyde (MDA). We measured two personality traits: neophobia (latency to approach food near novel objects) and object exploration (latency to approach novel objects). These traits were uncorrelated. ROMs, OXY, OS and MDA were also uncorrelated with each other. Highly neophobic birds had lower OXY, higher ROMs and higher OS than less neophobic birds. Fast exploring birds had higher OXY than slow explorers, but did not differ in ROMs or OS. Variation in MDA was described by a quadratic relationship with neophobia: birds with extremely high or low neophobia had lower MDA than birds with intermediate neophobia, despite highly neophobic birds exhibiting lower OS than intermediately neophobic birds. Additively in that model, fast explorers had lower MDA than slower explorers. To conclude: first, personality types can differ in oxidative profile. Second, although physiological differences (e.g. hormonal stress responsiveness) between personality types generally range along a linear continuum, physiological costs may not. Finally, relationships with oxidative profile differed between neophobia and object exploration. Understanding how oxidative profile and thus physiological costs vary within and between personality traits may explain how differences in personality traits can predict fitness.

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Section: Introductionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Oxidative profile varies with personality in European greenfinches

Herborn

Coffey²,

Larcombe³

et al. 2011

Journal of Experimental Biology

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“…Less aggressive male mice have shorter lifespans, and it has been suggested that the age-related decline in the concentrations of catecholamines and testosterone might be responsible for their reduced longevity (Ewalds-Kwist & Selander 1996). Given the present results and the fact that OS may modulate ageing (Harman 1956;Beckman & Ames 1998), the redox status could explain the differences in lifespan that different personalities experience (Cavigelli & McClintock 2003).…”

Section: Discussionmentioning

confidence: 64%

Aggressive and non-aggressive personalities differ in oxidative status in selected lines of mice ( Mus musculus )

et al. 2007

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Mice selected for aggression and coping (long attack latency (LAL), reactive coping strategy; short attack latency (SAL), pro-active coping strategy) are a useful model for studying the physiological background of animal personalities. These mice also show a differential stress responsiveness, especially in terms of hypothalamic-pituitary-adrenal axis reactivity, to various challenges. Since the stress response can increase the production of reactive oxygen species, we predicted that the basic oxidative status of the lines could differ. We found that LAL showed higher serum antioxidant capacity (OXY ) than SAL, while no differences emerged for reactive oxygen metabolites (ROMs) or the balance between ROMs and OXY, reflecting oxidative stress. Moreover, the lines showed inverse relationships between ROMs or OXY and body mass corrected for age. The results indicate that variation in oxidative status is heritable and linked to personality. This suggests that different animal personalities may be accompanied by differences in oxidative status, which may predict differences in longevity.

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“…The mice were then given access to preweighed food for a period of 72 hr, after which the remaining food and bedding were reweighed. The difference between the preweighed food and the remaining food was the measure of food intake (Ewalds- Kvist & Selander, 1996;Hansen & Ferreira, 1986). By comparing the weight of the bedding in the cage before and after the test period, a measure of excretion (i.e., defecation and urination) was established (Ewalds- Kvist & Selander).…”

Section: Methodsmentioning

confidence: 99%

Mice Selectively Bred for Open-Field Thigmotaxis: Life Span and Stability of the Selection Trait

Leppänen¹,

Ewalds-Kvist²,

Selander³

2005

The Journal of General Psychology

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In 2 experiments, the authors examined 69 mice selectively bred for high or low levels of open-field (OF) thigmotactic behavior (high open-field thigmotaxis [HOFT] and low open-field thigmotaxis [LOFT], respectively). They found that the strains differed in defecation during the 60-min exposure to the OF. Furthermore, the strains differed with regard to their life spans: The more thigmotactic HOFT mice lived longer than the LOFT mice. The strains were not differentiated by food intake or excretion. The strain difference in thigmotaxis was not age dependent, and it persisted in the home-cage condition as well. Neither the location (center or wall) of the starting point nor the shape (circular or square) of the OF arena affected the difference in wall-seeking behavior between the two strains. The authors concluded that the difference in thigmotaxis (or emotionality) between the HOFT and LOFT mice is a stable and robust feature of these animals.

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Life spans in mice from strains selected for high or low aggression

Cited by 6 publications

References 23 publications

Oxidative profile varies with personality in European greenfinches

Oxidative profile varies with personality in European greenfinches

Aggressive and non-aggressive personalities differ in oxidative status in selected lines of mice ( Mus musculus )

Mice Selectively Bred for Open-Field Thigmotaxis: Life Span and Stability of the Selection Trait

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