Life spans of different strains of mice as affected by acute irradiation with 100 PKV X‐rays

Abstract

Agriculture and Mechanical A r t s FOUR FIQURESThe consequences following radiant energy absorption in the body have been measured by changes observed in isolated segments of the body as changes in particular organs, tissues, cells o r cell components. These observations are pertinent to an understanding of the mechanisms by which radiant energy acts. The lesions observed specify the entities which in sum total create the effects on life. Life span represents an integration of these many body parts as they measure up in function day by day. The many factors involved include those inherent in the animal as well as those which are outside the animal or are environmental. This leads to high variability between individuals. Difficult as this measure is for this reason, life span represents the only overall evaluation of the effects on the animal's well being which takes into account all of the factors involved. Information from one of our several experiments designed to furnish data on this question are presented in this paper. MATERIALS AND METHODSThe X-rays utilized were generated by a Coolidge tube operating at 98 pkv, 2.5 ma. The mice were exposed at 36.5 cm

Effects of partial-body X-radiation on learning of inbred strains of mice

“…The inbred mice had been separated into distinct strains through 30+ generations of brcrther-by-sister matings* Both strains are homozygous albino but differ in many physiological characteristics including total body weight, weight of organs, number of leucocytes, metabolism of fat, storage of glycogen, and resistance to Salmonella typhimurium (Gowen, 1950;Gowen and Stadler, 1956;Stadler and Gowen, 1957 Having made one error, a mouse could make another by leaving the incorrect alley by one full body length and then either returning to the incorrect alley or entering the central alley* A limit of 5 minutes per trial ws set. Any mouse remaining $ minutes was shoved to the goal.…”

“…Gowen and Stadler (1956) demonstrated that the LD^Q was different for different inbred strains of the same species.…”

Volitional activity of inbred and hybrid mice as influenced by x-radiation

“…Furthermore, Kohn, et al (1957) have detected structural changes in irradiated mice present from 7 weeks to 330 days after treatment, during a time in which little or no differ ences between surviving irradiated mice and controls are grossly apparent. In regard to lethality, it has been shown by many investigators (Gowen and Stadler, 1956;Glaus, 1958) that re covery from the initial acute effects of radiation does not as sure an animal of an average life span. Apparently, the phys iological changes and deterioration associated with advancing chronological age occur more rapidly in irradiated mice than in non-irradiated mice.…”

Volitional activity of inbred and hybrid mice as influenced by x-radiation

“…In regard to lethality, it has been shown by many investigators (Gowen and Stadler, 1956;Glaus, 1958) that re covery from the initial acute effects of radiation does not as sure an animal of an average life span. Apparently, the phys iological changes and deterioration associated with advancing chronological age occur more rapidly in irradiated mice than in non-irradiated mice.…”