Life stage and endpoint sensitivity differences of fathead minnow (Pimephales promelas) to chemicals with various modes of action

Wang, Yolina Yu Lin; Li, Ping; Ohore, Okugbe Ebiotubo; Wang, Yuwen; Zhang, Dainan; Bai, Yunfei; Su, Tenghui; You, Jing; Jin, Xiaowei; Liu, Wenhua; Wang, Zhen

doi:10.1016/j.envpol.2021.117995

Cited by 9 publications

(2 citation statements)

References 53 publications

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“…Because chemicals with different modes of action may have markedly different toxicity (B. Fan, Fan, et al, 2019; Mácová et al, 2009; Su et al, 2021; Wang et al, 2021), the fragrances were classified according to Verhaar and ECOSAR chemical classes (Supporting Information, Table S2). The 29 fragrances cover three Verhaar categories and approximately 30% belong to Class 1 (inert chemicals), 3.3% to Class 2 (less inert chemicals), and over 66% to Class 3 (reactive chemicals; Supporting Information, Figure S1 and Table S2).…”

Section: Resultsmentioning

confidence: 99%

Investigations On the Fish Acute Toxicity of Fragrance Ingredients Involving Chinese Fish Species and Zebrafish Embryos

Zhou

Bai

et al. 2022

Enviro Toxic and Chemistry

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While zebrafish (Danio rerio) have been accepted worldwide for evaluating chemical hazards to aquatic vertebrates, and in some countries it is mandated to generate fish toxicity data using native species, such as Chinese rare minnow (Gobiocypris rarus) in China. This represents an additional regulatory constraint that may cause redundant tests, additional animal uses, and higher costs. Previous studies showed that juvenile G. rarus was more sensitive than zebrafish juveniles and embryos to metals. To better understand the sensitivity of G. rarus to organic chemicals, we selected 29 fragrance ingredients belonging to various chemical classes and with differing physicochemical properties, for which good quality zebrafish acute toxicity data were available and tested them with juvenile G. rarus and embryo D. rerio using the Organisation of Economic Co-operation and Development test guidelines. Chemical toxicity distribution (CTD) and chemical ratio distribution (CRD) models were established to systematically compare the sensitivity between juveniles of G. rarus and D. rerio, as well as between D. rerio embryos and juveniles. The results of the CTD models showed that for tested chemicals, the sensitivity of juvenile G. rarus was similar to that of D. rerio juveniles and embryos. The CRD comparisons revealed that juvenile G. rarus was slightly less sensitive by a factor of ~2 than juvenile D. rerio to ingredients belonging to Verhaar class 3 and Ecological Structure Activity Relationship ester class, while comparable to other chemicals. These comparative experiments demonstrated that fish toxicity data with G. rarus can be submitted for use in chemical registrations outside China, which would avoid repeating animal tests using D. rerio. Meanwhile, the similar sensitivity of zebrafish juveniles and embryos to fragrance ingredients confirmed the suitability of replacing juveniles by zebrafish embryos.

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Section: Resultsmentioning

confidence: 99%

Investigations On the Fish Acute Toxicity of Fragrance Ingredients Involving Chinese Fish Species and Zebrafish Embryos

Zhou

Bai

et al. 2022

Enviro Toxic and Chemistry

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“…When predicting the responses of populations or ecosystems to toxic stress, reproductive outputs such as fecundity, gamete function, fertilization success, embryo development, or larval survivorship are more ecologically relevant to measure than adult physiological or biochemical changes. However, studies using reproductive end points are likely to be more informative of the higher-level effects as these changes can be linked directly to recruitment and are modeled to calculate the main demographic indices and other population statistics (Lewis and Watson, 2012;Wang et al, 2021b). We selected the most commonly used toxicity end points for use in this study.…”

Section: Categorymentioning

confidence: 99%

Derivation of predicted no-effect concentrations for thirty-five pharmaceuticals and personal care products in freshwater ecosystem

et al. 2022

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Pharmaceuticals and personal care products (PPCPs) are contaminants of emerging concern. PPCPs have been detected in various environmental matrices, posing potential threat to human health and environment quality. Thus far, there are no water quality guidelines (WQGs) established for PPCPs for the protection of freshwater organisms and ecosystems. In this study, we used the species sensitivity distribution (SSD) and assessment factor (AF) approaches to derive the 5% hazardous concentrations (HC5) of 35 selected PPCPs using acute and chronic toxicity data. The predicted no-effect concentrations (PNECs) and the acute-to-chronic ratios (ACRs) of chemicals were inherently computed to support the derivation of WQGs and for ecological risk assessment. Among these, endocrine-disrupting chemicals and antipsychotics were shown to pose a greater threat to the freshwater environment and organisms. The highest PNEC was recorded for chloramphenicol (3,620 μg/L) and the lowest for fluoxetine (0.0000291 μg/L), which could have significant ecological risks. In addition, the commonly used default ACRs do not seem to provide adequate support for the prediction of chronic toxicity thresholds and WQGs, as the highest ACRs of these drugs reached 39,100 (e.g., chloramphenicol). The findings of this study provide critical scientific information regarding the development of WQGs for environmental management and the risk control of PPCPs.

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Impacts of cetylpyridinium chloride on the behavior and brain neurotransmitter levels of juvenile and adult zebrafish (Danio rerio)

Dong

Chen

et al. 2022

Comparative Biochemistry and Physiology Part C: Toxicology &

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Life stage and endpoint sensitivity differences of fathead minnow (Pimephales promelas) to chemicals with various modes of action

Cited by 9 publications

References 53 publications

Investigations On the Fish Acute Toxicity of Fragrance Ingredients Involving Chinese Fish Species and Zebrafish Embryos

Investigations On the Fish Acute Toxicity of Fragrance Ingredients Involving Chinese Fish Species and Zebrafish Embryos

Derivation of predicted no-effect concentrations for thirty-five pharmaceuticals and personal care products in freshwater ecosystem

Impacts of cetylpyridinium chloride on the behavior and brain neurotransmitter levels of juvenile and adult zebrafish (Danio rerio)

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