Life-threatening Agranulocytosis, Anemia, and Plasmacytosis After Dipyrone Use for Fever in a Child

Işık, Melek; Kaya, Zühre; Belen, Fatma Burcu; Aktaş, Anıl; Tezer, Hasan; Gürsel, Türkiz

doi:10.1097/mph.0b013e31826e7d9d

Cited by 14 publications

(10 citation statements)

References 6 publications

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“…Therefore, the present risk seems to be unknown in infants; however, there are single case reports of children older than 1 year with (nonlethal) agranulocytosis after multiple metamizole doses for treatment of fever. [10][11][12] Other more common ADRs of metamizole are hemodynamic, anaphylactic or respiratory reactions. In accordance with our previous study, 3 HR and MAP remained stable during metamizole infusion also in infants, and the numbers of patients with MAP increases and decreases were comparable.…”

Section: Discussionmentioning

confidence: 99%

Metamizole for Postoperative Pain Therapy in Infants Younger than 1 Year

et al. 2016

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Due to possible serious adverse drug reactions (ADRs), the use of metamizole for postoperative pain therapy in infants is a subject of debate. Safety studies with large sample sizes are missing. This prospective multicenter observational study was conducted to evaluate the use of metamizole in infants younger than 1 year undergoing surgery with a particular focus on possible serious ADRs (e.g., hemodynamic, anaphylactic or respiratory reactions, and agranulocytosis). Infants aged up to 1 year (American Society of Anesthesiologists [ASA] I-III) receiving a single dose of metamizole for postoperative pain therapy were enrolled. Patient demographics, main and secondary diagnosis, surgical procedures performed, metamizole dose, hemodynamic data, use of other analgesics and regional blocks, results of pain measurement, and incidence of ADRs were documented using a standardized case report form. A total of 316 infants observed at five pediatric centers were included for analysis (age 4.4 ± 3.7 [0.06-12] months). Mean metamizole dose was 17.8 ± 3.1 (9.2-29.8) mg·kg. Mean arterial pressure (MAP) remained stable during metamizole infusion (MAP before infusion 45 ± 9.5 [25-95] and after infusion 45 ± 9.2 [25-99] mm Hg). Erythema was observed in one patient (ADRs total: 0.3%, 95% confidence interval: 0.27-0.32). No respiratory adverse events directly related to the metamizole administration and no clinical signs of agranulocytosis were reported. Single intravenous doses of metamizole used for prevention or treatment of postoperative pain were safe in more than 300 infants younger than 1 year. The statistical probability of serious ADRs (e.g., hemodynamic, anaphylactic or respiratory reactions) was lower than 1%. The sample size and follow-up were not sufficient to detect agranulocytosis.

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Section: Discussionmentioning

confidence: 99%

Metamizole for Postoperative Pain Therapy in Infants Younger than 1 Year

et al. 2016

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“…Bu üç olgu da steroid ve hematopoietik büyüme faktörü tedavisi ile düzelmiştir. [115][116][117] Ülkemizde akut postoperatif ağrı yönetiminde kullanımı yaygın değildir. Erken veya geç dönemde ortaya çıkabilecek pansitopeniden çekinilmektedir.…”

Section: Parenteralunclassified

Pharmachologic treatment of acute postoperative pain: A clinical practice guideline of The Turkish Society of Algology

Reisli

Akkaya

Arıcan

et al. 2021

Agri

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“…Some adverse effects of metamizole are agranulocytosis, anemia, acute renal failure, severe thrombocytopenia and DRESS syndrome [7,8,9]. …”

Section: Discussionmentioning

confidence: 99%

Metamizole Associated Acute Generalized Exanthematous Pustulosis

2016

J turk acad dermatol

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Observation: Acute generalized exanthematous pustulosis is a rare and severe cutaneous reaction generally triggered by drug intake. Metamizole is a frequently used drug as an analgesic and antipyretic all over the world. Although it's widely usage there are only a few report about metamizole associated acute generalized exanthematous pustulosis. Herein we present a 49-yearold man with AGEP due to metamizol.

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Life-threatening Agranulocytosis, Anemia, and Plasmacytosis After Dipyrone Use for Fever in a Child

Cited by 14 publications

References 6 publications

Metamizole for Postoperative Pain Therapy in Infants Younger than 1 Year

Metamizole for Postoperative Pain Therapy in Infants Younger than 1 Year

Pharmachologic treatment of acute postoperative pain: A clinical practice guideline of The Turkish Society of Algology

Metamizole Associated Acute Generalized Exanthematous Pustulosis

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