Life-threatening graft-vs-host disease

Vargas-Díez, E; García‐Diez, Amaro; Marín, Alicia C; Fernández‐Herrera, Jesús

doi:10.1016/j.clindermatol.2004.06.005

Cited by 44 publications

(51 citation statements)

References 139 publications

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“…Patients describe a sensation of skin pain or itching, followed by a morbilliform rash. 79 In severe cases, the eruption becomes generalized with widespread areas of epidermal necrosis and denudation.…”

Section: Histopathology and Differential Diagnosismentioning

confidence: 99%

Toxic epidermal necrolysis

Pereira

Mudgil

Rosmarin

2007

Journal of the American Academy of Dermatology

287

237

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Section: Histopathology and Differential Diagnosismentioning

confidence: 99%

Toxic epidermal necrolysis

Pereira

Mudgil

Rosmarin

2007

Journal of the American Academy of Dermatology

287

237

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“…Chronic GVHD can occur in up to 80%, with the usual sites affected including the skin, liver, oral or vaginal mucosa, gastrointestinal tract, lungs, and eyes. [32][33][34] Those at risk for chronic GVHD include patients receiving an allogeneic transplant, those with histocompatability disparities between donor and recipient, previous severe acute GVHD, and older age of the patient and/or donor, as well as mismatch in sex between donor and recipient. 35 Patients with skin involvement affecting more than 50% of their body surface area, as well those with persistent thrombocytopenia and hyperbilirubinemia, are at risk for reduced survival.…”

Section: Stem Cell Transplantmentioning

confidence: 99%

Pain and Palliative Care Needs of Cancer Survivors

Lynch¹,

Paice

2011

Journal of Hospice & Palliative Nursing

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As palliative care shifts from care of the dying to a broader focus on an integrated model where treatment is directed to any patient with a life-threatening illness, nurses working in this area will need to become familiar with common pain syndromes seen in those surviving their illness. In particular, pain syndromes in persons surviving cancer are being seen with greater frequency in the clinical setting. These include persistent pain due to surgery, chemotherapy, radiotherapy, stem cell transplant, and hormonal therapy. To illustrate the complex array of complications that can occur as a result of cancer treatment, a case is presented that describes the course experienced by one patient many years after therapy, as well as the management provided by the palliative care and hospice teams.

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“…AGVHD generally occurs 4 weeks after stem cell transplantation. Patients describe a sensation of skin pain and itching followed by a morbilliform rash that in severe cases becomes generalized with diffuse areas of epidermal necrosis [116]. Mucositis is usually present.…”

Section: Differential Diagnosismentioning

confidence: 99%

Severe Cutaneous Adverse Reactions

Fernando¹

2013

Skin Biopsy - Diagnosis and Treatment

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Life-threatening graft-vs-host disease

Cited by 44 publications

References 139 publications

Toxic epidermal necrolysis

Toxic epidermal necrolysis

Pain and Palliative Care Needs of Cancer Survivors

Severe Cutaneous Adverse Reactions

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