The association between comorbidities and inpatient mortality with sudden sensorineural hearing loss (SSNHL) has not been investigated. Therefore, this study aimed to provide a 14-year nationwide incidence, and identify risk factors and comorbidities of SSNHL inpatient mortality. Methods: Data were obtained from the Taiwan National Health Insurance Research Database for 2000 to 2013. Inpatient mortality of 31,258 patients hospitalized with a diagnosis of SSNHL was recorded and analyzed. Results: Sixteen patients with SSNHL exhibited mortality with a percentage of 0.05% and an incidence of less than 0.01 per 100,000 people per year. The risk of variables among inpatient mortality was associated with older age (adjusted odds ratio [OR]: 1.042, 95% confidence interval [CI]: 1.009-1.077) and the presence of catastrophic illness (adjusted OR: 4.949, 95% CI: 1.290-18.996). Potential comorbidities included hematologic diseases, cancers, chronic hepatitis, gastrointestinal bleeding, chronic obstructive pulmonary disease, seizures or convulsions, coronary artery disease, diabetes mellitus, and varicose veins and their associated complications.