Life-Threatening Sochi Virus Infections, Russia

Krüger, Detlev H.; Ткаченко, Е. А.; Морозов, В. Г.; Yunicheva, Yulia V.; Пиликова, О. М.; Malkin, Gennadiy; Ишмухаметов, А. А.; Heinemann, Patrick; Witkowski, Peter T.; Klempa, Boris; Dzagurova, Tamara K.

doi:10.3201/eid2112.150891

Cited by 20 publications

(15 citation statements)

References 12 publications

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“…Partial nucleotide sequences of S, M, and L segments amplified from serum derived from the DOBV-Sochi patient were deposited in GenBank (accession numbers KU529946, KU529944 and KU529945). The sequences showed high similarity to DOBV-Sochi sequences obtained from Black Sea field mice ( Apodemus ponticus ) and from a fatal case of hantavirus disease reported in a 47-year-old woman in the district of Krasnodar in southern European Russia (Table 1) [13, 20, 21]. No pre-existing conditions, such as renal, pulmonary or cardiovascular disease, diabetes mellitus, hypertension or obesity, were found.…”

Section: Case Presentationmentioning

confidence: 87%

“…Among Old World hantaviruses, DOBV genotype Sochi is characterized by severe clinical course and a high CFR of 14.5% [13]. In contrast, PUUV disease exhibits a low CFR of less than 1% [31].…”

Section: Discussionmentioning

confidence: 99%

“…However, the species-specific factors of hantaviruses that are responsible for pathogenicity and clinical picture are not identified so far. Interestingly, the pathogenicity of related viruses of DOBV genotypes differs enormously with case fatality rates (CFRs) between 0.3%-0.9% for DOBV genotype Kurkino and 14.5% for DOBV genotype Sochi [13]. In addition to severe courses that are linked to specific virus species or genotypes, several serious cases were reported for infection with PUUV that usually causes a milder form of hantavirus disease [14, 15].…”

Section: Introductionmentioning

confidence: 99%

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Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi

et al. 2016

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BackgroundHantavirus disease belongs to the emerging infections. The clinical picture and severity of infections differ between hantavirus species and may even vary between hantavirus genotypes. The mechanisms that lead to the broad variance of severity in infected patients are not completely understood. Host- and virus-specific factors are considered.Case presentationWe analyzed severe cases of hantavirus disease in two young women. The first case was caused by Puumala virus (PUUV) infection in Germany; the second case describes the infection with Dobrava-Belgrade virus (DOBV) in Russia. Symptoms, laboratory parameters and cytokine levels were analyzed and compared between the two patients. Serological and sequence analysis revealed that PUUV was the infecting agent for the German patient and the infection of the Russian patient was caused by Dobrava-Belgrade virus genotype Sochi (DOBV-Sochi). The symptoms in the initial phase of the diseases did not differ noticeably between both patients. However, deterioration of laboratory parameter values was prolonged and stronger in DOBV-Sochi than in PUUV infection. Circulating endothelial progenitor cells (cEPCs), known to be responsible for endothelial repair, were mobilized in both infections. Striking differences were observed in the temporal course and level of cytokine upregulation. Levels of angiopoietin-2 (Ang-2), vascular endothelial growth factor (VEGF), and stromal derived factor-1 (SDF-1α) were increased in both infections; but, sustained and more pronounced elevation was observed in DOBV-Sochi infection.ConclusionsSevere hantavirus disease caused by different hantavirus species did not differ in the general symptoms and clinical characteristics. However, we observed a prolonged clinical course and a late and enhanced mobilization of cytokines in DOBV-Sochi infection. The differences in cytokine deregulation may contribute to the observed variation in the clinical course.

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Section: Case Presentationmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi

et al. 2016

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“…Viruses account for the majority of newly emerging human pathogens. Over the past few years, many different viruses such as SARS coronavirus, MERS coronavirus, avian influenza viruses, hantaviruses, Zaire ebolavirus, or Zika virus have (re)emerged as human pathogens [1][2][3][4][5][6][7]. Vaccines are the most efficient and cost-effective tools to fight infectious diseases, particularly virus infections.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of Viruses by Large-Scale Recoding of their Genomes: the Selection Is Always Biased

Osterrieder

Kunec

2018

Curr Clin Micro Rpt

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Purpose of Review This review summarizes the current understanding of virus attenuation by large-scale recoding of viral genomes and discusses what would ultimately be necessary for construction of better and safer live modified virus vaccines. Recent Findings It has been shown that codon and codon pair deoptimization are rapid and robust methods that can be used for the development of attenuated vaccine candidates. The viruses attenuated by large-scale recoding have the added value that they are extremely genetically stable. However, the exact mechanisms that lead to viral attenuation by recoding are yet to be determined. Summary While the advantages of large-scale recoding (speed, simplicity, potency, and universal applicability) have been known for more than a decade, this approach has been only inadequately explored and the attention was focused on a limited number of RNA viruses. Attenuation of viruses by large-scale recoding should be explored to combat known and future viral threats.

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“…The main hantaviruses which cause human disease in Europe are Dobrava–Belgrade virus (DOBV) associated with Apodemus flavicollis , Apodemus agrarius , and Apodemus ponticus , and Puumala virus (PUUV) associated with Myodes glareolus . DOBV strains associated with A. flavicollis and A. ponticus have the potential to cause the most severe form of HFRS, which is characterized by fever, headache, gastrointestinal symptoms, renal dysfunction, and hemorrhagic manifestations, with a fatality rate of approximately 10% [Papa, ; Kruger et al, ].…”

Section: Introductionmentioning

confidence: 99%

Genetic detection of hantaviruses in rodents, Albania

et al. 2016

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In order to have a first insight into the epidemiology of hantaviruses in Albania, 263 small mammals (248 rodents, 15 insectivores) were captured in 352 locations in 29 districts and tested for hantavirus infection. Dobrava-Belgrade virus (DOBV) was detected in 10 of 148 (6.7%) Apodemus flavicollis rodents. DOBV-positive A. flavicollis were detected in six districts (Diber, Korce, Kolonje, Librazhd, Pogradec, and Vlore). The obtained nucleotide sequences were highly similar to each other and to DOBV sequences from northwestern Greece. Understanding the epidemiology of hantaviruses and identifying the endemic foci enables the public health strategies to minimize the risk of human infection. J. Med. Virol. 88:1309-1313, 2016. © 2016 Wiley Periodicals, Inc.

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Life-Threatening Sochi Virus Infections, Russia

Abstract: Sochi virus was recently identified as a new hantavirus genotype carried by the Black Sea field mouse, Apodemus ponticus. We evaluated 62 patients in Russia with Sochi virus infection. Most clinical cases were severe, and the case-fatality rate was as high as 14.5%.

Cited by 20 publications

References 12 publications

Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi

Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi

Attenuation of Viruses by Large-Scale Recoding of their Genomes: the Selection Is Always Biased

Genetic detection of hantaviruses in rodents, Albania

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