Life‐threatening ventricular tachycardia due to liquorice‐induced hypokalaemia

Eriksson, Johan; Carlberg, Bo; Hillörn, Valter

doi:10.1046/j.1365-2796.1999.00476.x

Cited by 55 publications

(29 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultimately, increased mineralocorticoid activity cause potassium excretion as well as sodium and water retention, thus leading to hypokalemia and edema. [7,8] Negative feedback of renin-angiotensin II suppresses plasma renin and aldosterone, as was found in the present study.…”

Section: Discussionsupporting

confidence: 77%

Atrial fibrillation due to licorice root syrup

Erkuş

Altıparmak

Demirbağ

et al. 2016

Arch Turk Soc Cardiol

View full text Add to dashboard Cite

Özet-Meyan kalp ritim bozukluklarına neden olabilir. Ancak, meyan kökü şerbetinin içiminden kaynaklanan atriyum fibrilasyonu, şu ana kadar bildirilmemiştir. Daha önce kalp ve damar hastalığı bulunmayan 57 yaşında erkek hasta acil servise çarpıntı şikayetiyle başvurdu. Laboratuvar incelemesinde potasyum 2.0 mmol/L olup plazma renin aktivitesi ve aldesteron düzeyi ise baskılanmıştı (<300 ng/L/saat, 42 ng/L, sırayla). Elektrokardiyogramda yüksek ventrikül hızlı atriyum fibrilasyonu görüldü. Yapı-lan ekokardiyografik incelemede, kalp boşlukları normal sınırlarda olup kalp kapaklarının yapısı ve fonksiyonları da normal olarak değerlendirildi. Hastada bulunan atriyum fibrilasyonu, propafenon infüzyonu ile sinüs ritmine çevrildi.Summary-While it is known that consumption of licorice may lead to cardiac arrhythmias, there have been no reports of atrial fibrillation resulting from the consumption of licorice root syrup. A 57-year-old male with no prior history of cardiovascular disease was admitted to the emergency department with palpitation. His electrocardiogram showed atrial fibrillation with a moderate to rapid ventricular rate. In laboratory assessment, potassium was 2.0 mmol/L and plasma renin activity and aldosterone level were suppressed (<300 ng/L/hour, 42 ng/L respectively). Volumes of the heart chambers were within normal range and functions and structures of the heart valves were normal in echocardiographic assessment. The arrhythmia was resolved with propafenone infusion. 237

show abstract

Section: Discussionsupporting

confidence: 77%

Atrial fibrillation due to licorice root syrup

Erkuş

Altıparmak

Demirbağ

et al. 2016

Arch Turk Soc Cardiol

View full text Add to dashboard Cite

show abstract

“…Licorice possesses many therapeutic properties, including effects against gastric ulcer, cough, sputa, convulsion, inflammation, and allergy, and hepatoprotective effects (8,9). Adverse effects of licorice include hypertension, hypokalaemia, myopathy, muscle weakness, edema, cardiac dysrhythmias, and loss of consciousness (10,11).…”

mentioning

confidence: 99%

Inhibitory Effects of Isoliquiritigenin and Licorice Extract on Voltage-Dependent K+ Currents in H9c2 Cells

et al. 2008

View full text Add to dashboard Cite

Abstract. The effect of isoliquiritigenin (ISL), a component of licorice, on the voltagedependent, ultra-rapidly activating delayed-rectifier K + current (IKur) was examined in H9c2 cells, a cell-line derived from rat cardiac myoblasts. IKur was recorded using the whole-cell patch clamp method with a pipette solution containing 140 mM K + . Depolarizing voltage pulses of 200-ms duration were given with 10-mV steps every 10 s from −40 mV holding potential. ISL inhibited IKur in a concentration-dependent manner. The median inhibitory concentration (IC 50 ) of ISL was approximately 0.11 μM and the Hill coefficient was 0.71. Using CHO cells expressing Kv1.5 IKur channels, ISL also inhibited Kv1.5 IKur, but less potently than the IKur current in H9c2 cells. Furthermore, in H9c2 cells, the licorice extract itself inhibited IKur in a manner similar to ISL. We conclude that ISL, one component of licorice, is a potent inhibitor of K + channels, which specifically in H9c2 cells could be Kv2.1, and that this inhibition may be involved in various pharmacological effects of licorice.

show abstract

“…Hypokalemia also decreases the activity of rapid-activating delayed-rectifier channels (I kr ), which play a role in repolarization. Hypokalemia itself is a well-known major risk factor for TdP [7,8].…”

Section: Discussionmentioning

confidence: 99%

Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice

et al. 2009

View full text Add to dashboard Cite

We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia. He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy. After taking him off all drugs and administering spironolactone supplemented with potassium, his low serum potassium level was ameliorated. Therefore, although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third-generation quinolone antibiotics, one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP.

show abstract

Life‐threatening ventricular tachycardia due to liquorice‐induced hypokalaemia

Cited by 55 publications

References 6 publications

Atrial fibrillation due to licorice root syrup

Atrial fibrillation due to licorice root syrup

Inhibitory Effects of Isoliquiritigenin and Licorice Extract on Voltage-Dependent K+ Currents in H9c2 Cells

Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice

Contact Info

Product

Resources

About