Life-Threatenting Ceftriaxone-Induced Immune Hemolytic Anemia in a Child with Crohn’s Disease

Systematic review: managing anaemia in Crohn's disease

“…Others Mattis et al . reported a case of ceftriaxone‐induced haemolytic anaemia in a child with CD 83 …”

Ceftriaxone-related hemolysis and acute renal failure

“…In one case, the child's symptoms were resolved with withdrawal of ceftriaxone and no other therapy [8]. In two of the other cases, the child died within hours of the initial symptoms [9,10].…”

Ceftriaxone-induced Hemolytic Anemia

“…Eighteen of these patients, including our patient had previous exposure to ceftriaxone. 4,6,7,[16][17][18][19][20][21][22][23]25,[28][29][30][31] There was no information reported in the remaining 5 patients. 3,5,24,26,27 It is unclear whether the underlying disease processes contribute to the development of anticeftriaxone antibodies and hemolysis, or if repeated exposure to the drug is important, or both.…”

“…In the review of 23 CIHA pediatric patients, 9 patients including our patient did not receive any further ceftriaxone after hemolysis and 8 (89%) of these patients survived. 19,[21][22][23][24]26,30,31 Ceftriaxone therapy was continued in 8 CIHA patients. Four of these 8 patients died, 1 patient had repeated cardiorespiratory arrests with subsequent ceftriaxone doses, 1 patient developed severe renal failure requiring 14 days of hemodialysis, and 1 patient survived with severe neurological deficit.…”