1994
DOI: 10.1136/bmj.308.6921.131b
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Lifelong penicillin unproved in trials..

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Cited by 17 publications
(2 citation statements)
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“…Most authorities recommend the administration of prophylactic antibiotics to asplenic or hyposplenic children, especially for the first 2 years after splenectomy [1,5,18]. However, there are no controlled data relating to the efficacy of chemoprophylaxis in asplenic adult patients despite the fact that some recent guidelines have recommended lifelong antibiotics [19,20]. Concern over increasing resistance of pneumococci to commonly used prophylactic agents together with patient compliance issues has influenced others to advise that chemoprophylaxis should be limited to a supply of standby antibiotics for the patient to self-prescribe at the first sign of possible infection if unable to seek prompt medical attention [2,7,17,21].…”
Section: Discussionmentioning
confidence: 99%
“…Most authorities recommend the administration of prophylactic antibiotics to asplenic or hyposplenic children, especially for the first 2 years after splenectomy [1,5,18]. However, there are no controlled data relating to the efficacy of chemoprophylaxis in asplenic adult patients despite the fact that some recent guidelines have recommended lifelong antibiotics [19,20]. Concern over increasing resistance of pneumococci to commonly used prophylactic agents together with patient compliance issues has influenced others to advise that chemoprophylaxis should be limited to a supply of standby antibiotics for the patient to self-prescribe at the first sign of possible infection if unable to seek prompt medical attention [2,7,17,21].…”
Section: Discussionmentioning
confidence: 99%
“…Ορισμένοι ερευνητές συνηγορούν στη συνέχιση της χημειοπροφύλαξης μέχρι την ηλικία των 16-18 στην δοθείσα αγωγή(Finch et al 1994). Επομένως, δε συνιστάται γενικά η μακροχρόνια χορήγηση αντιμικροβιακής αγωγής στους ενήλικες(Makris et al 1994). Επιπλέον, με βάση τη διεθνή βιβλιογραφία, υπάρχει η σύσταση χορήγησης εμπειρικής αντιμικροβιακής αγωγής μόλις εμφανιστούν τα πρώτα σημεία λοίμωξης (αύξηση θερμοκρασίας σώματος, ρίγη ή φρίκια) σε περίπτωση που δεν μπορεί να ληφθεί άμεσα ιατρική μέριμνα για τον ασθενή.…”
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