Lifelong treadmill training improves muscle function detected by a modified grip strength test during aging in BALB/c mice

Alterations in mitochondrial biogenesis and respiratory activity, inflammation of the senescence‐associated secretory phenotype, and lipolysis in the perirenal fat and liver of rats following lifelong exercise and detraining

“…Additionally, elderly women with anti‐inflammatory profile‐associated (increased IL‐10 production) genotypes demonstrated improved physical performance 39 . Notably, an evident increase in grip strength and maximal tensile force was recorded following lifelong exercise (Figure 2B,D), which is consistent with previous observations that mice participating in lifelong exercise training have relatively high levels of such parameters with slightly increased grip power during the aging period 40 . The aging process is characterized by a chronic inflammatory status and increase in total body fat and fat infiltration in the liver 1 .…”

“…39 Notably, an evident increase in grip strength and maximal tensile force was recorded following lifelong exercise (Figure 2B,D), which is consistent with previous observations that mice participating in lifelong exercise training have relatively high levels of such parameters with slightly increased grip power during the aging period. 40 The aging process is characterized by a chronic inflammatory status and increase in total body fat and fat infiltration in the liver. 1 Obviously, excess weight in old age also contributes to declines in physical function.…”

pH-Responsive Plasmon-Enhanced Persistent Luminescent ZnGa2O4:Cr3+ Nanopomegranate for Tumor Imaging

“…Surrounding the spheric tumor cells, abnormal flattened nucleus and fibrotic structures can be seen distinctly, and the typical stripes of skeletal muscles have fully vanished. Such a consequence could be ascribed to the oppression and inbreak of tumor cells, or in another circumstance, owing to the muscle fibrosis, which results from neoplastic muscle damage and secondary inflammation. − In the histological picture of “tumor 2”, some intact transections of skeletal muscles and deeply dyed carcinoma cells are clearly demonstrated, , which suggests the elimination of the tumor residuals together with surrounding normal tissue. The obtained data verified the high performance of ZSPB@AuNPs on surgical navigation, which helps to resect most of the carcinomas and corresponding abnormal tissues invaded by tumor cells.…”

Environmental Enrichment Improves Motor Function and Muscle Transcriptome of Aged Mice

“…Preserving muscle function or strength could potentially mitigate age-related loss of physical function. [5,7,18,34,35] Our current study focused on EE's impact on aged motor function, as well as muscle physiology and the associated molecular signature. The onset of sarcopenia-related loss of muscle mass begins near 24-months of age in female C57BL/6J mice [36] one group reported that grip strength was reduced in 24-month-old C57BL/6J mice [27] In line with these studies, the mice utilized in the current study were 25-months of age at the experimental endpoint.…”