Lifespan changes in motor activation and inhibition during choice reactions: A Laplacian ERP study

Laar, Maria C. van de; Wildenberg, Wery P. M. van den; Boxtel, G.J.M. van; Huizenga, Hilde M.; Molen, Maurits W. van der

doi:10.1016/j.biopsycho.2011.11.005

Cited by 35 publications

(28 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data confirmed and extended the observation that cognitive performance, as measured by reaction times, showed a significant deterioration in middle-aged and older subjects (Smith and Brewer, 1995, 58–75 years; Yordanova et al, 2004, mean 58 years; Der and Deary, 2006, 18–81 years; Albinet et al, 2012, 61–84 years; van de Laar et al, 2012, mean 75 years).…”

Section: Discussionsupporting

confidence: 89%

Increased reaction times and reduced response preparation already starts at middle age

Wolkorte

Kamphuis

Zijdewind

2014

Front. Aging Neurosci.

View full text Add to dashboard Cite

Generalized slowing characterizes aging and there is some evidence to suggest that this slowing already starts at midlife. This study aims to assess reaction time changes while performing a concurrent low-force and high-force motor task in young and middle-aged subjects. The high-force motor task is designed to induce muscle fatigue and thereby progressively increase the attentional demands. Twenty-five young (20–30 years, 12 males) and 16 middle-aged (35–55 years, 9 males) adults performed an auditory two-choice reaction time task (CRT) with and without a concurrent low- or high-force motor task. The CRT required subjects to respond to two different stimuli that occurred with a probability of 70 or 30%. The motor task consisted of index finger abduction, at either 10% (10%-dual-task) or 30% (30%-dual-task) of maximal voluntary force. Cognitive task performance was measured as percentage of correct responses and reaction times. Middle-aged subjects responded slower on the frequent but more accurately on the infrequent stimuli of CRT than young subjects. Both young and middle-aged subjects showed increased errors and reaction times while performing under dual-task conditions and both outcome measures increased further under fatiguing conditions. Only under 30%-dual-task demands, an age-effect on dual-task performance was present. Both single- and dual-task conditions showed that already at mid-life response preparation is seriously declined and that subjects implement different strategies to perform a CRT task.

show abstract

Section: Discussionsupporting

confidence: 89%

Increased reaction times and reduced response preparation already starts at middle age

Wolkorte

Kamphuis

Zijdewind

2014

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Average MRPs were computed from this corrected activity for each stimulus and channel of interest. Analyses focused on activity measured at scalp sites C3 and C4 because they are located above the two motor cortices (Eimer, 1998; Leuthold, 2003; Spencer & Coles, 1999) and previous studies on inhibitory control and motor preparation have shown that these areas are involved in the activation and suppression of correct and incorrect motor responses (Burle, 2004; van de Laar, van den Wildenberg, van Boxtel, Huizenga, & van der Molen, 2012). The EEG activity recorded at these sites was filtered at a bandwidth of 1 Hz (high pass) to 30 Hz (low pass), and a roll-off of 24dB/octave.…”

Section: Methodsmentioning

confidence: 99%

“…To estimate current source densities (CSDs) and to improve the spatial resolution of the EEG signals (Nunez & Srinivasan, 2006), a Surface Laplacian transformation was applied (Perrin, Pernier, Bertrand, & Echallier, 1989). After the CSD transform, MRP averages were calculated at C3 and C4 for the different conditions (instruction, correspondence, and electrode-response side) and low-pass filtered at 15 Hz (van de Laar et al, 2012). …”

Section: Methodsmentioning

confidence: 99%

“…This negative wave is thought to reflect activation of the motor cortex that controls the goal-directed correct response (e.g., C3 for responses by the right hand). Concurrently, a positive-going wave develops at electrodes contralateral to the non-selected response hand (i.e., ipsilateral to the responding hand; e.g., C4 for responses by the right hand) that is thought to reflect the simultaneous inhibition of activity in the motor cortex that controls production of the incorrect response (for reviews see Burle, 2004; Carbonell et al, 2004; Meckler et al, 2010; Meynier, Burle, Possamai, Vidal, & Hasbroucq, 2009; van de Laar et al, 2012; Vidal et al, 2003). Given the deficits in inhibitory action control among PD patients, we reasoned that the response-locked surface Laplacian technique could provide new insights about the degree of suppression of conflicting motor responses at M1, especially in situations involving speed stress.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Speed pressure in conflict situations impedes inhibitory action control in Parkinson's disease

Wouwe

Wildenberg

Claassen

et al. 2014

Biological Psychology

View full text Add to dashboard Cite

Parkinson’s disease (PD) is a neurodegenerative basal ganglia disease that disrupts cognitive control processes involved in response selection. The current study investigated the effects of PD on the ability to resolve conflicts during response selection when performance emphasized response speed versus response accuracy. Twenty-one (21) PD patients and 21 healthy controls (HC) completed a Simon conflict task, and a subset of 10 participants from each group provided simultaneous movement-related potential (MRP) data to track patterns of motor cortex activation and inhibition associated with the successful resolution of conflicting response tendencies. Both groups adjusted performance strategically to emphasize response speed or accuracy (i.e., speed-accuracy effect). For HC, interference from a conflicting response was reduced when response accuracy rather than speed was prioritized. For PD patients, however, there was a reduction in interference, but it was not statistically significant. The conceptual framework of the Dual-Process Activation-Suppression (DPAS) model revealed that the groups experienced similar susceptibility to making fast impulsive errors in conflict trials irrespective of speed-accuracy instructions, but PD patients were less proficient and delayed compared to HC at suppressing the interference from these incorrect response tendencies, especially under speed pressure. Analysis of MRPs on response conflict trials showed attenuated inhibition of the motor cortex controlling the conflicting impulsive response tendency in PD patients compared to HC. These results further confirm the detrimental effects of PD inhibitory control mechanisms and their exacerbation when patients perform under speed pressure. The results also suggest that a downstream effect of inhibitory dysfunction in PD is diminished inhibition of motor cortex controlling conflicting response tendencies.

show abstract

“…The ability to rapidly start and swiftly execute a movement decreases with age (Fozard et al, 1994, Der and Deary, 2006, Langan et al, 2010, van de Laar et al, 2012, Wolkorte et al, 2014). Not only movement initiation, but also prompt termination of a hand movement is important for activities of daily living.…”

Section: Introductionmentioning

confidence: 99%

Delayed grip relaxation and altered modulation of intracortical inhibition with aging

et al. 2015

View full text Add to dashboard Cite

Grip relaxation is a voluntary action that requires an increase in short-interval intracortical inhibition (SICI) in healthy young adults, rather than a simple termination of excitatory drive. The way aging affects this voluntary inhibitory action and timing of grip relaxation is currently unknown. The objective of this study was to examine aging-related delays in grip relaxation and SICI modulation for the flexor digitorum superficialis (FDS) muscle during grip relaxation. The main finding was that young adults increased SICI to relax their grips, whereas older adults did not increase SICI with a prolonged grip relaxation time (p<0.05 for both SICI modulation and grip relaxation time). A secondary experiment showed that both young and older adults did not change H reflex excitability during grip relaxation. Our data suggest that grip relaxation is mediated by increased cortical inhibitory output in young adults, and aging-related impairment in increasing cortical inhibitory output may hamper timely cessation of muscle activity. Our data also suggest a lesser role of the spinal circuits in grip muscle relaxation. This knowledge may contribute to understanding of aging-related movement deterioration and development of interventions for improving modulation of SICI to improve muscle relaxation and movement coordination.

show abstract

Lifespan changes in motor activation and inhibition during choice reactions: A Laplacian ERP study

Cited by 35 publications

References 74 publications

Increased reaction times and reduced response preparation already starts at middle age

Increased reaction times and reduced response preparation already starts at middle age

Speed pressure in conflict situations impedes inhibitory action control in Parkinson's disease

Delayed grip relaxation and altered modulation of intracortical inhibition with aging

Contact Info

Product

Resources

About