Lifestyle alters GUT-bacteria function: Linking immune response and host

Jazayeri, Omid; Daghighi, S. Mojtaba; Rezaee, Farhad

doi:10.1016/j.bpg.2017.09.009

Cited by 15 publications

(12 citation statements)

References 127 publications

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“…Qin et al [43] reported that the gut microbiota in patients with type 2 diabetes showed higher levels of Bacteroidetes and E. coli compared with controls. In another study, the gut microbiota of obese and type 2 diabetic patients had a high abundance of Proteobacteria [44]. Similar findings linking the gut microbiota to fat mass and BW have been observed in diet-induced obese mice [45].…”

Section: Discussionsupporting

confidence: 67%

“…Accordingly, Proteobacteria-derived LPS is associated with systemic chronic low-grade inflammation and an increase in the serum levels of LPS can be indicative of an imbalance in the microbiome in obesity [22]. Furthermore, the gut microbiota map of non-vegetarians has a higher abundance of E. coli compared with that of vegetarians [44]. Therefore, we suggest that there is a link between the decrease in abundance of Proteobacteria (Escherichia) and the intake of REP or a rice-based diet.…”

Section: Discussionmentioning

confidence: 99%

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Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood

et al. 2019

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Obesity and related disorders, which are increasing in adults worldwide, are closely linked to childhood diet and are associated with chronic inflammation. Rice endosperm protein (REP) intake during adulthood has been reported to improve lipid metabolism and suppress the progression of diabetic kidney disease in animal models. However, the effects of REP intake during childhood on adulthood health are unclear. Therefore, we used a mouse model to experimentally investigate the preconditioning effects of REP intake during childhood on the development of obesity and related disorders in adulthood. Male C57BL/6J mice were pair-fed a normal-fat diet containing casein or REP during the juvenile period and then a high-fat diet (HFD) containing casein or REP during adulthood. Mice fed REP during the juvenile period showed better body weight, blood pressure, serum lipid profiles, lipopolysaccharide (LPS)-binding protein levels, and glucose tolerance in adulthood than those fed casein during the juvenile period. HFD-induced renal tubulo-glomerular alterations and hepatic microvesicular steatosis were less evident in REP-fed mice than in casein-fed ones. REP intake during the juvenile period improved HFD-induced dysbiosis (i.e., Escherichia genus proliferation and reduced gut microbiota diversity), thereby suppressing endotoxin-related chronic inflammation. Indeed, REP-derived peptides showed antibacterial activity against Escherichia coli, a major producer of LPS. In conclusion, REP supplementation during the juvenile period may regulate the gut microbiota and thus suppress the development of obesity and related disorders in adulthood in mice.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood

et al. 2019

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“…Bacteria that are predominantly found in healthy people, e.g., Bacteroidetes and Firmicutes, are present in people who follow a diet that is low in fat and high in dietary fibre. e intestinal microflora may be disadvantageous when fats (SFA) are dominant in the diet [23]. However, current scientific reports indicate uncertain connections between products such as red meat and its derivatives, which are a significant source of SFA, and disease activity.…”

Section: E Influence Of Fats On the Development And Course Of Inflammmentioning

confidence: 99%

The Influence of Nutrients on Inflammatory Bowel Diseases

Jarmakiewicz-Czaja

Piątek

Filip

2020

Journal of Nutrition and Metabolism

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Inflammatory bowel diseases is a group of inflammatory diseases. e pathogenesis of diseases is multifactorial, which may include a Western-type diet. Diseases occur with periods of recurrence and remission. Many factors can have a beneficial effect on reducing the frequency of recurrence and prolonging the remission period. Such ingredients include dietary fibre, mono-and polyunsaturated fatty acids, certain vitamins (D, C, and E), flavonoids, and minerals such as zinc and selenium. Properly selected nutrition might be an integral part of the treatment of patients with Crohn's disease or ulcerative colitis.

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“…Diet has a major influence on the gut microbiota which will influence the state of inflammation or “priming” of the innate response, the adaptive response and the reception given by the microbial flora to invasion by novel organisms.…”

Section: The Three Phases Of Crohn's Diseasementioning

confidence: 99%

The role of neutrophils in the pathogenesis of Crohn's disease

Segal

2018

Eur J Clin Investigation

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Crohn's disease (CD) is caused by a trigger, almost certainly enteric infection by one of a multitude of organisms that allows faeces access to the tissues, at which stage the response of individuals predisposed to CD is abnormal. In CD the failure of acute inflammation results in the failure to recruit neutrophils to the inflammatory site, as a consequence of which the clearance of bacteria from the tissues is defective. The retained faecal products result in the characteristic chronic granulomatous inflammation and adaptive immune response. Impaired of digestion of bacteria and fungi by CGD neutrophils can result in a similar pathological and clinical picture. The neutrophils in CD are normal and their inadequate accumulation at sites of inflammation generally results from diminished secretion of proinflammatory cytokines by macrophages consequent upon disordered vesicle trafficking.

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Lifestyle alters GUT-bacteria function: Linking immune response and host

Cited by 15 publications

References 127 publications

Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood

Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood

The Influence of Nutrients on Inflammatory Bowel Diseases

The role of neutrophils in the pathogenesis of Crohn's disease

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