Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study

El-Khairy, Lina; Ueland, Per Magne; Nygård, Ottar; Refsum, Helga; Vollset, Stein Emil

doi:10.1093/ajcn/70.6.1016

Cited by 140 publications

(97 citation statements)

References 37 publications

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“…Lifestyle factors such as vitamin intake, smoking, physical activity, and consumption of alcohol, coffee and tea have been related to tHcy in several cross-sectional populationbased studies (Nygard et al, 1998;El Khairy et al, 1999;Rasmussen et al, 2000;de Bree et al, 2001b;Saw et al, 2001;Husemoen et al, 2004). Moreover, tHcy has also been associated with various lifestyle-related biological risk factors such as blood pressure, cholesterol and different measures of body weight (Nygard et al, 1995;Jacques et al, 2001;Panagiotakos et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study

Husemoen¹,

Linneberg²,

Fenger

et al. 2009

Eur J Clin Nutr

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Background/Objectives: Total homocysteine (tHcy) has been associated with increased risk of several diseases in the general population. It is not clear whether these associations are causal. A less healthy lifestyle as well as a less favorable biological risk factor profile have been related to increased tHcy in cross-sectional studies. In addition, the methylenetetrahydrofolate reductase (MTHFR) C677T gene variant is an important determinant of elevated tHcy. The main objective of the study was to examine the effect of changes in biological risk factors and lifestyle on tHcy in relation to MTHFR C677T genotype. Subjects/Methods: The study is a population-based study including 1805 men and women aged 30-60 years participating in a health examination at baseline (1999)(2000)(2001) and at a 5-year follow-up examination. Results: Changes in tHcy were not associated with changes in dietary habits, physical activity, smoking status, coffee, tea, total alcohol or wine consumption. An inverse relationship was observed between changes in tHcy and changes in the intake of beer in TT individuals but not in CC/CT individuals (P interaction ¼ 0.01). In addition, changes in tHcy were positively associated with changes in several biological risk factors, such as waist circumference, diastolic blood pressure, total cholesterol and LDL cholesterol (Po0.01). The association between waist circumference and MTHFR genotype seemed stronger in TT individuals than in CC/CT individuals (P interaction ¼ 0.03). Conclusions: tHcy was not influenced by lifestyle changes except for the inverse association between beer consumption and tHcy observed in TT individuals. This suggests that tHcy is not a mediator in the causal pathway between lifestyle and lifestylerelated diseases such as cardiovascular disease in accordance with results of recent randomized trials. However, tHcy was related to changes in several biological risk factors, suggesting that tHcy may be a good predictor or marker of disease.

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Section: Introductionmentioning

confidence: 99%

Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study

Husemoen¹,

Linneberg²,

Fenger

et al. 2009

Eur J Clin Nutr

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“…Reduction in tHcy may thus be clinically relevant in the prevention of CVD, and it is therefore important to identify modifiable factors that influence tHcy. Lifestyle factors such as vitamin intake, smoking, physical activity and consumption of alcohol, coffee and tea have been related to tHcy in several cross-sectional populationbased studies (Nygard et al, 1998;El Khairy et al, 1999;Rasmussen et al, 2000;De Bree et al, 2001a, b;Saw et al, 2001;Husemoen et al, 2004). Moreover, tHcy has also been associated with various lifestyle-related biological CVD risk markers such as blood pressure, cholesterol and different measures of body weight (Nygard et al, 1995;Jacques et al, 2001;Panagiotakos et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

et al. 2005

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Background: Reduction in total homocysteine (tHcy) may be clinically relevant in the prevention of cardiovascular disease (CVD) in the general population. Objective: To examine the effects of changes in various lifestyle habits and lifestyle related biological CVD risk markers on changes in tHcy in relation to MTHFR(C677T) genotype. Design: A 1 year follow-up study. Setting: Copenhagen County, Denmark. Subjects: Statistical analyses were based on a population-based sample of 915 men and women aged 30-60 years assessed to be at increased CVD risk at baseline and therefore offered lifestyle intervention and re-examination after one year. Results: None of the studied lifestyle changes -smoking, physical activity, dietary habits, and coffee, tea, and alcohol consumption -was significantly associated with changes in tHcy, either overall, or in any of the MTHFR genotype subgroups. In addition, changes in tHcy did not differ between participants randomized to low-and high-intensity lifestyle intervention. However, the MTHFR TT genotype was associated with a significant decrease in tHcy compared with the CC/CT genotype in which an increase was observed. In addition, changes in tHcy were associated with changes in several of the biological CVD risk markers: weight, total cholesterol, HDL cholesterol, LDL cholesterol and systolic blood pressure. Conclusions: Our results indicate that tHcy may not be reduced by lifestyle changes; additionally, they suggest that tHcy may be related to biological CVD risk markers through a lifestyle independent pathway.

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“…The relationships between MMA, tHcy and cysteine are potentially important because both tHcy and cysteine (Mansoor et al, 1995;El-Khairy et al, 1999) can independently predict vascular disease risk, tHcy is increased in vitamin B 12 deficiency as one among several determinants, and the combination of serum vitamin B 12 and MMA estimates can therefore be used to distinguish the vitamin B 12 -deficiency-effects on tHcy from those of other nutrient deficiencies and influences.…”

Section: Introductionmentioning

confidence: 99%

Relationship between methylmalonic acid, homocysteine, vitamin B12 intake and status and socio-economic indices, in a subset of participants in the British National Diet and Nutrition Survey of people aged 65 y and over

et al. 2003

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Objective: Assessment of functional vitamin B 12 status in a subset of the respondents in the British National Diet and Nutrition Survey of people aged 65 y and over. Setting: National Diet and Nutrition Survey: a British nationwide cross-sectional sample of people aged 65 y and over, living either in the community or in institutions such as nursing homes, during one calendar year spanning 1994 -1995. Methods: Methylmalonic acid (MMA) concentrations were measured in plasma samples from 313 subjects (ca 14% of those originally enrolled in the survey). The results were compared with those for serum vitamin B 12 , vitamin B 12 intakes and other status and intake estimates and with socio-demographic indices. Results: Of the NDNS participants overall, 20% had serum vitamin B 12 concentrations < 150 pmol=l. In the subset studied here, 24% of free-living and 46% of institution-living participants had MMA >0.5 mmol=l. Geometric mean MMA increased with age, from 0.25 mmol=l in people aged 65 -74 y to 0.38 mmol=l in people aged 85 þ y. There was little evidence for any gender difference in MMA. It was inversely correlated with serum vitamin B 12 and with red blood cell folate; it was positively correlated directly with total homocysteine, but not significantly with serum folate or with vitamin B 12 intake. Among respondents with high MMA, a subgroup had normal serum vitamin B 12 but higher-than-average plasma urea and creatinine. Socio-demographic co-variates of MMA included receipt of State income benefits, social class of head of household, and educational attainment. These indices were not correlated with serum vitamin B 12 . Conclusions: The progressive increase in MMA with age is metabolic evidence for increasing risk of functional vitamin B 12 deficiency with increasing age in older people. There is evidence that renal function is linked to high MMA in some older people. Age and renal function are thus both important when establishing upper reference limits for MMA. The socio-demographic observations suggest a link between poverty and poor functional vitamin B 12 status in older British people.

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Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study

Abstract: Plasma tCys is strongly related to several factors that constitute the cardiovascular disease risk profile. This should be an incentive to determine the role of tCys in cardiovascular disease.

Cited by 140 publications

References 37 publications

Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study

Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study

Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

Relationship between methylmalonic acid, homocysteine, vitamin B12 intake and status and socio-economic indices, in a subset of participants in the British National Diet and Nutrition Survey of people aged 65 y and over

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