Lifestyle and demographic factors associated with human semen quality and sperm function

Abstract

BMI: body mass index; SA: semen analysis; AR: acrosome reaction; DFI: DNA fragmentation index; GAM: generalized additive model; TSC: total sperm count; TMC: total motile sperm count; IUI: intrauterine insemination; SCSA: sperm chromatin structure assay; SD: standard deviation; IQR: interquartile range; CBAVD: congenital bilateral absence of vas deferens; NEQAS: national external quality assessment service; HTF: human tubal fluid; HSA: human serum albumin.

Associations of bedtime, sleep duration, and sleep quality with semen quality in males seeking fertility treatment: a preliminary study

“…In the present study, a sleep duration shorter than 7.5 h was associated with reduced semen quality. Shorter sleep durations have previously been linked to reduced semen quality in a limited number of studies [8,9,13,14]. The optimal sleep duration in relation to semen quality in the most comparable study, which was conducted with Chinese university students, was 7.0-7.5 h [9] and thus shorter than in our study.…”

“…The disruption of the circadian rhythm has also been associated with lower levels of urinary 8hydroxydeoxyguanosine likely caused by reduced melatonin levels indicating a reduced ability to repair oxidative deoxyribonucleic acid (DNA) damage which is important for fertility [24]. In line with this, Shi et al [13] found a higher DNA fragmentation index (DFI) in men with irregular sleep. Prescribing regiments of reasonable bedtimes with relevant sleep durations could prove an important factor in increasing the fertility of men based on the currently available literature and the results of the present study.…”

“…Green et al [14] found a positive correlation between sleep duration and total sperm and motility. Shi et al [13] found sperm concentrations to be lower in men with a short sleep duration and higher in men with a long sleep duration in 328 Hong Kongese men.…”

“…These include increased risk of cardio-metabolic complications, hypertension, obesity, type 2-diabetes, cardiovascular disease, urologic complications, cancer, and depression [1][2][3][4][5][6]. Results from a limited number of recent studies suggest that inadequate bedtimes, short sleep duration, and poor sleep, assessed as poor self-reported sleep quality, may impact semen quality [7][8][9][10][11][12][13].…”

“…Sleep duration itself has been linked to semen quality in fertile [9] and in infertile [13,14] men. Chen et al [9] found the optimal sleep duration to be 7.0-7.5 h in 796 Chinese fertile men.…”