Lifestyle and environmental contributions to ovulatory dysfunction in women of polycystic ovary syndrome

Qian, Zhendong; Zhou, Wei; Shi, Yuhua; Zhang, Jun; Cui, Linlin; Chen, Zi‐Jiang

doi:10.1186/s12902-020-0497-6

Cited by 50 publications

(32 citation statements)

References 47 publications

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“…Environmental factors items in table 3as: use of plastic-packaged food, disposable plastic cup for drinking and exposure to cooking oil fumesare most factors found in this study which contribution to ovulatory dysfunction that causes PCOS correspond with study done in china (12) .…”

Section: Food Consumption In Tablesupporting

confidence: 75%

Assessment of Associated Factors and Complications for Women with Poly Cystic Ovarian Syndrome in Baghdad City

Alyaa Khazaal Neamah,

Hala S. Abdulwahid,

Hind Sadoon Lateef

2021

MLU

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Objectives: To assess the associated factors and complication for women with poly cystic ovarian syndrome. Methodology: A descriptive study conducted on purposive sample of (65) women whom attended Hospitals in Baghdad city suffering polycystic ovarian syndrome for the period of (20th October 2019 through 25th February 2020). Descriptive & Inferential statistical analyses were used to analyze the data. Results: The highest percentages (50%) in age group were (19-22) years, primary schools graduates, housewife, from "urban area", with irregular cycle. Take high grains, fat, sugar in their food And suffered from obesity, hirsutism, acne,amenorrhea, infertility among short term complication. Conclusions: The study concluded that there is significant relationship between occupation, body mass index, food consumption, dietary habits, environmental factors, with short term complication of PCOS. Recommendations: Need to developed training program to upgrade their knowledge and skills about healthy food and life style to reduction the complication of PCOS.

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Section: Food Consumption In Tablesupporting

confidence: 75%

Assessment of Associated Factors and Complications for Women with Poly Cystic Ovarian Syndrome in Baghdad City

Alyaa Khazaal Neamah,

Hala S. Abdulwahid,

Hind Sadoon Lateef

2021

MLU

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“…Lastly, from the four phenotypes in the Rotterdam criteria we chose to dichotomize into two phenotypes (ovulatory and anovulatory) due to small numbers in the groups and that might have affected the results. However, this dichotomization has been previously used before supporting our current approach [42].…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life in women with polycystic ovary syndrome attending to a tertiary hospital in Southeastern Spain: a case-control study

Sánchez-Ferrer

Adoamnei

Prieto-Sánchez

et al. 2020

Health Qual Life Outcomes

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Background: Polycystic ovary syndrome (PCOS) is a chronic condition with symptoms affecting many women at reproductive age and evaluating their health-related quality of Life (HRQoL) is an important issue. Moreover, differences in the HRQoL between women with different PCOS phenotypes have never been analyzed. Therefore, the aim of our study was to compare the HRQoL between women with PCOS-and its phenotypes-and controls attending to a tertiary hospital. Methods: A group of 117 women with PCOS and 153 controls were studied between 2014 and 2016. Controls were women without PCOS attending the gynecological outpatient clinic for routine examinations. Cases were women attending the same setting and diagnosed with PCOS. PCOS diagnose was performed following the Rotterdam Criteria and women were further classified by anovulatory or ovulatory phenotypic subtype. Women underwent physical and gynecological exams and completed health questionnaires including the Short Form-12v2. Eight scales and two component summary scores [Physical (PCS) and Mental (MCS), respectively] were calculated. Bivariate and multivariate analyses were performed to assess differences in HRQoL between women with PCOS and controls. Results: All women with PCOS and anovulatory PCOS presented lower score in PCS compared to controls [mean (95%CI): 53.7 (52.5-54.9) and 52.9 (51.5-54.4) vs. 55.8 (54.8-56.8); p-values< 0.01], as well as lower scores for five out of the eight scales (p-values < 0.05) after adjusting by age, body mass index, infertility, educational level and current occupation. No significant differences were observed for the MCS between women with or without PCOS or its phenotypic subtypes. Conclusions: HRQoL was significantly decreased in adult women with PCOS and its anovulatory phenotype compared to controls attending the outpatient clinic of a tertiary hospital. These results may have implications for the clinical practice and suggest the need for specific interventions in women with PCOS.

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“…The issue of the impacts of various environmental factors on PCOS pathogenesis has recently been the subject of several reviews [ 66 ], with numerous factors, such as exposure to environmental toxins, diet and nutrition [ 67 ]; and socioeconomic status and geography, having been discussed in detail. Consequently, only the most relevant recent advances are mentioned herein.…”

Section: Leading Factors In Pcos Pathogenesismentioning

confidence: 99%

In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond

Wawrzkiewicz-Jałowiecka

Kowalczyk

Trybek

et al. 2020

IJMS

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In a healthy female reproductive system, a subtle hormonal and metabolic dance leads to repetitive cyclic changes in the ovaries and uterus, which make an effective ovulation and potential implantation of an embryo possible. However, that is not so in the case of polycystic ovary syndrome (PCOS), in which case the central mechanism responsible for entraining hormonal and metabolic rhythms during the menstrual cycle is notably disrupted. In this review we provide a detailed description of the possible scenario of PCOS pathogenesis. We begin from the analysis of how a set of genetic disorders related to PCOS leads to particular malfunctions at a molecular level (e.g., increased enzyme activities of cytochrome P450 (CYP) type 17A1 (17α-hydroxylase), 3β-HSD type II and CYP type 11A1 (side-chain cleavage enzyme) in theca cells, or changes in the expression of aquaporins in granulosa cells) and discuss further cellular- and tissue-level consequences (e.g., anovulation, elevated levels of the advanced glycation end products in ovaries), which in turn lead to the observed subsequent systemic symptoms. Since gene-editing therapy is currently out of reach, herein special emphasis is placed on discussing what kinds of drug targets and which potentially active substances seem promising for an effective medication, acting on the primary causes of PCOS on a molecular level.

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Lifestyle and environmental contributions to ovulatory dysfunction in women of polycystic ovary syndrome

Cited by 50 publications

References 47 publications

Assessment of Associated Factors and Complications for Women with Poly Cystic Ovarian Syndrome in Baghdad City

Assessment of Associated Factors and Complications for Women with Poly Cystic Ovarian Syndrome in Baghdad City

Health-related quality of life in women with polycystic ovary syndrome attending to a tertiary hospital in Southeastern Spain: a case-control study

In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond

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