Lifestyle and environmental factors associated with inflammation, oxidative stress and insulin resistance in children

Kelishadi, Roya; Mirghaffari, Nourollah; Poursafa, Parinaz; Gidding, Samuel S.

doi:10.1016/j.atherosclerosis.2008.06.022

Cited by 227 publications

(192 citation statements)

References 50 publications

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“…Além dos efeitos da poluição atmosférica sobre as doenças respiratórias e imunológicas, e também sobre os estágios iniciais da aterosclerose 4,31 , sugeridos anteriormente, os achados do nosso estudo propõe uma associação entre poluentes do ar e atividade da medula óssea. Ao considerar os efeitos carcinogênicos dos poluentes atmosféricos para as crianças 32 , nossos achados podem alertar para efeitos mais preocupantes da poluição atmosférica para a saúde das crianças.…”

Section: Discussionunclassified

“…Para a avaliação dos hábitos alimentares, o Índice de Alimentação Saudável (IAS) foi computado como descrito anteriormente 4 . O nível de atividade física foi avaliado por meio do Physical Activity Questionnaire for Children, de abrangência internacional, previamente validado em crianças iranianas 18 .…”

Section: Estudo Clínico E Métodos Laboratoriaisunclassified

“…No dia da coleta de sangue, os sete últimos níveis diários de poluentes atmosféricos e do Pollutant Standards Index (PSI) da estação de monitoramento localizada na área de residência de cada participante foram registrados e incluídos na análise estatística 4 . Foram registrados os valores diários referentes aos principais poluentes atmosféricos, isto é, dióxido de enxofre (SO 2 ), ozônio (O 3 ), material particulado (particulate matter) ≤ 10 µm (PM 10 ), dióxido de nitrogênio (NO 2 ) e monóxido de carbono (CO), e também o PSI, a temperatura média diária, a duração da luz solar, a umidade e a velocidade do vento.…”

Section: Dados Sobre a Poluição Do Arunclassified

“…Consistente com alguns achados anteriores, um estudo experimental recente demonstrou pela primeira vez que a exposição respiratória ao material particulado estimula o processo de aterogenêse 2 ; portanto, esse pode ser o elo entre poluição do ar e doenças cardiovasculares. Além disso, sugere-se que o estado pró-inflamatório contribui para a ocorrência de fatores de risco cardiometabólicos, e a associação da poluição atmosférica com esses fatores de risco está documentada tanto em adultos 3 quanto em adolescentes 4 .…”

Section: Introductionunclassified

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Association of air pollution and hematologic parameters in children and adolescents

Poursafa¹,

Kelishadi²,

Amini³

et al. 2011

J Pediatr (Rio J)

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Objective: To assess the relationship of air pollution and hematologic parameters in a population-based sample of children and adolescents. Methods:This cross-sectional study was conducted in 2009-2010 among school students randomly selected from different areas of Isfahan city, the second largest and most air-polluted city in Iran. The association of air pollutants levels with hemoglobin, platelets, red and white blood cells (RBC and WBC, respectively) levels was determined by multiple linear and logistic regression analyses, after adjustment for age, gender, anthropometric measures, meteorological factors, and dietary and physical activity habits. Results:The study participants consisted of 134 students (48.5% boys) with a mean age of 13.10±2.21 years. While the mean Pollutant Standards Index (PSI) was at moderate level, the mean particulate matter ≤ 10 µm (PM 10 ) was more than twice the normal level. Multiple linear regression analysis showed that PSI and most air pollutants, notably PM 10 , had significant negative relationship with hemoglobin and RBC count, and positive significant relationship with WBC and platelet counts. The odds ratio of elevated WBC increased as the quartiles of PM 10 , ozone and PSI increased, however these associations reached to significant level only in the highest quartile of PM 10 and PSI. The corresponding figures for hemoglobin and RBC were in opposite direction. Conclusions:The association of air pollutants with hematologic parameters and a possible pro-inflammatory state is highlighted. The presence of these associations with PM 10 in a moderate mean PSI level underscores the necessity to re-examine environmental health policies for the pediatric age group.J Pediatr (Rio J). 2011;87(4): Air pollution, cell blood count, atherosclerosis, inflammation, children, prevention. ResumoObjetivo: Avaliar a relação entre poluição atmosférica e parâ-metros hematológicos em uma amostra populacional de crianças e adolescentes. Métodos:Este estudo transversal foi realizado em 2009-2010 com estudantes escolhidos aleatoriamente de diversas áreas de Isfahan, a segunda maior e mais poluída cidade iraniana. A associação entre os níveis de poluentes do ar e os de hemoglobina, plaquetas, glóbulos brancos (GB) e glóbulos vermelhos (GV) foi determinada pelas análises linear múltipla e de regressão logística ajustadas para idade, sexo, medidas antropométricas, fatores meteorológicos, e hábitos alimentares e de atividade física. Resultados:Participaram do estudo 134 estudantes (48,5% meninos), com idade média de 13,10±2,21 anos. Com níveis moderados de Pollutant Standards Index (PSI), a média de material particulado (particulate matter) ≤ 10 µm (PM 10 ) foi mais do que o dobro do normal. A análise de regressão linear demonstrou que o PSI e a maioria dos poluentes atmosféricos, especialmente PM 10 , estiveram negativamente relacionados com a contagem de hemoglobina e GV e positivamente relacionados com a contagem de GB e plaquetas. O odds ratio de uma elevação nos GB aumentou conforme os quart...

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Section: Discussionunclassified

Section: Estudo Clínico E Métodos Laboratoriaisunclassified

Section: Dados Sobre a Poluição Do Arunclassified

Section: Introductionunclassified

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Association of air pollution and hematologic parameters in children and adolescents

Poursafa¹,

Kelishadi²,

Amini³

et al. 2011

J Pediatr (Rio J)

Self Cite

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“…Heart attack or AMI or acute coronary syndrome (ACS) is highly dynamic state associated with pro-inflammatory, severe neuro-endocrinological dysfunction, apart from myocardial damage [40][41][42][43] . There is marked increase in sympathetic activity, oxidative stress and inflammation, free fatty acids, dyslipidemia and deficiency of magnesium, potassium, coenzyme Q10 as well as in vitamin A, C, E and beta-carotine during the ACS event.…”

Section: Intervention Trials With Function Foods and Heart Attackmentioning

confidence: 99%

Functional Food Security and the Heart

Singh¹,

Shastun

Чибисов

et al. 2017

Journal of Cardiology and Therapy

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Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults

Thompson

Houck

Adair

et al. 2013

American J Hum Biol

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Objectives Influenced by pathogen exposure and obesity, inflammation provides a critical biological pathway linking changing environments to the development of cardiometabolic disease. This study tests the relative contribution of obesogenic and pathogenic factors to moderate and acute CRP elevations in Chinese children, adolescents and adults. Methods Data come from 8795 participants in the China Health and Nutrition Study. Age-stratified multinomial logistic models were used to test the association between illness history, pathogenic exposures, adiposity, health behaviors and moderate (1-10 mg/L in children and 3-10 mg/L in adults) and acute (>10mg/L) CRP elevations, controlling for age, sex and clustering by household. Backward model selection was used to assess which pathogenic and obesogenic predictors remained independently associated with moderate and acute CRP levels when accounting for simultaneous exposures. Results Overweight was the only significant independent risk factor for moderate inflammation in children (RRR 2.10, 95%CI 1.13-3.89). History of infectious (RRR 1.28, 95%CI 1.08-1.52) and non-communicable (RRR 1.37, 95%CI 1.12-1.69) disease, overweight (RRR 1.66, 95%CI 1.45-1.89) and high waist circumference (RRR 1.63, 95%CI 1.42-1.87) were independently associated with a greater likelihood of moderate inflammation in adults while history of infectious disease (RRR 1.87, 95%CI 1.35-2.56) and overweight (RRR 1.40, 95%CI 1.04-1.88) were independently associated with acute inflammation. Environmental pathogenicity was associated with a reduced likelihood of moderate inflammation, but a greater likelihood of acute inflammation in adults. Conclusions These results highlight the importance of both obesogenic and pathogenic factors in shaping inflammation risk in societies undergoing nutritional and epidemiological transitions.

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Lifestyle and environmental factors associated with inflammation, oxidative stress and insulin resistance in children

Cited by 227 publications

References 50 publications

Association of air pollution and hematologic parameters in children and adolescents

Association of air pollution and hematologic parameters in children and adolescents

Functional Food Security and the Heart

Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults

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