Lifestyle and fertility: the influence of stress and quality of life on female fertility

Palomba, Stefano; Daolio, Jessica; Romeo, Sara; Battaglia, Francesco; Marci, Roberto; Sala, Giovanni

doi:10.1186/s12958-018-0434-y

Cited by 103 publications

(93 citation statements)

References 110 publications

(106 reference statements)

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“…2 Among various causes of DOR, psychological factors have emerged as an important one in recent years. [3][4][5] While acute or brief stressors only cause limited damage to women's fertility, chronic stressors can be detrimental to ovarian reserve, leading to adverse fertility outcomes. 4,6 Our previous animal study also indicated that chronic unpredictable stress (CUS) can induce a typical and long-lasting DOR phenotype in C57BL/6 mice.…”

Section: Introductionmentioning

confidence: 99%

<p>Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology</p>

Gao¹,

Zhang²,

Xu³

et al. 2020

DDDT

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Section: Introductionmentioning

confidence: 99%

<p>Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology</p>

Gao¹,

Zhang²,

Xu³

et al. 2020

DDDT

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“…In an extensive literature survey on the potential effects of stress on female fertility, Palomba and co-researchers 19 found that though it is difficult to unravel a cause effect relationship between stress and female fecundity, a strong correlation exists between measures of quality of life, stress, and reproductive function, more specifically in women who are experiencing problems of infertility.…”

Section: Resultsmentioning

confidence: 99%

Psychosocial Predictors of Medically Unexplained Infertility in Urban Working Women

Chakraborty

Gupta²,

Ray

2021

Journal of Psychosexual Health

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Background: Infertility is one of the major causes of mental health issues among couples. Interestingly, a large percentage of this infertility cannot be always explained in terms of a medical diagnosis. Psychological distress has long been suspected as having an important impact on infertility. However, the exact nature of association between psychological factors and infertility has been a subject matter of scientific debate. For modern urban women, there is an additional obligation of balancing work and home responsibilities; this dual role inevitably leads to stress. In this context, an important yet less-explored area of infertility is the role of work-related stress on female infertility. Aims: This study tries to investigate the mediating role of certain psychosocial constructs viz (a) Self-efficacy related to work-family conflict—measured in terms of “work-family conflict self-efficacy scale” by Cinamon (2003), (b) perceived occupational stress—measured in terms of “work-to-family conflict scale” by Netemeyer et al (1996), (c) decision-making in family—measured in terms of “decision-making scale” by Blood and Wolfe, (d) perceived infertility stress—measured in terms of “fertility problem inventory” by Newton et al (1999) in 25 urban working women of the age range 28 to 40 years who have been experiencing medically unexplained infertility for at least 1 year; the severity of infertility being measured in terms of duration of involuntary childlessness. Results: The analysis reveals that severity of medically unexplained infertility can be explained in terms of “self-efficacy related to work-family conflict” and “perceived infertility stress”; 28.6% of variation in severity of unexplained infertility being contributed by “self-efficacy related to work-family conflict” and 46.9% of the variation in the severity of unexplained infertility being contributed by a conjunction of “perceived infertility stress” and “self-efficacy related to work-family conflict.” Conclusion: The findings imply that urban educated women tend to place more psychological emphasis on “motherhood,” and “perceived deficit in attaining motherhood” seems to be the important source of personal stress for these women in comparison to stressors emanating from occupational hazards and family dynamics related to decision-making.

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“…[ 3 ] The diagnostic and therapeutic modalities of infertility assessments currently include many forms of artificial insemination and also pharmacologic and dietary treatments. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

Lepidiline A Improves the Balance of Endogenous Sex Hormones and Increases Fecundity by Targeting HSD17B1

Cheng

Shen

Ding

et al. 2020

Molecular Nutrition Food Res

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Scope: Maca (Lepidium meyenii), a well-known plant from the Andean highlands of Peru, has been used widely as a nutritional supplement to increase sexual function and fecundity. However, the identity of its active ingredients and how they function remain unknown. Methods and results: Chemical substances in maca are identified by UPLC-Q-TOF, and the active ingredients are screened through HotMap coupled with an artificial neural network. Lepidiline A (LA), an imidazole alkaloid, is identified as the key active compound. LA affects the balance of endogenous sex hormones in mice and improves fecundity in Drosophila. Using a molecular LA probe, 17ß-hydroxysteroid dehydrogenase type 1 (HSD17B1) is revealed to be the potential target of LA using a fishing-rod strategy. It is demonstrated with experimental data that LA targets HSD17B1 to enhance the enzyme's activity and increases its bioconversion efficiency of actively formed sex hormones including estrogen to 17 -estradiol and 4-androsten-3,7-dione to testosterone, which ultimately improves reproductive activity. Conclusion: LA improves the balance of endogenous sex hormones and increases fecundity by targeting HSD17B1. This underlying mechanism of action provides a useful insight into the application of maca in the regulation of dietary nutrition and healthy fertility.

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Lifestyle and fertility: the influence of stress and quality of life on female fertility

Cited by 103 publications

References 110 publications

<p>Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology</p>

<p>Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology</p>

Psychosocial Predictors of Medically Unexplained Infertility in Urban Working Women

Lepidiline A Improves the Balance of Endogenous Sex Hormones and Increases Fecundity by Targeting HSD17B1

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