Lifestyle and Memory in the Elderly

Flöel, Agnes; Witte, A. Veronica; Lohmann, Hubertus; Wersching, Heike; Ringelstein, E. Bernd; Berger, Klaus; Knecht, Stefan

doi:10.1159/000137378

Cited by 52 publications

(34 citation statements)

References 153 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Participants were asked to learn as many words as possible out of a list of 15 words. As primary outcome measure ''memory score,'' we considered the total number of retrieved words after 30 min (delayed memory), adjusted for false positive misidentifications (86,87), in line with previous studies (36,37,88), and with signal detection theory (89). Additionally, analysis was conducted for total number of retrieved words without adjustment for false-positives, and for total numbers of false-positive errors.…”

Section: Methodsmentioning

confidence: 99%

“…1). Because memory impairment is an early indication of AD and its precursor, MCI (35), we considered the ability to remember and learn new contents as our primary outcome measure, in accordance with previous studies on lifestyle interventions (36,37). Moreover, we tried to identify potential mechanisms underlying the positive effects of these dietary interventions.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Caloric restriction improves memory in elderly humans

Witte¹,

Fobker²,

Gellner³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

496

378

View full text Add to dashboard Cite

Animal studies suggest that diets low in calories and rich in unsaturated fatty acids (UFA) are beneficial for cognitive function in age. Here, we tested in a prospective interventional design whether the same effects can be induced in humans. Fifty healthy, normal- to overweight elderly subjects (29 females, mean age 60.5 years, mean body mass index 28 kg/m2) were stratified into 3 groups: (i) caloric restriction (30% reduction), (ii) relative increased intake of UFAs (20% increase, unchanged total fat), and (iii) control. Before and after 3 months of intervention, memory performance was assessed under standardized conditions. We found a significant increase in verbal memory scores after caloric restriction (mean increase 20%; P < 0.001), which was correlated with decreases in fasting plasma levels of insulin and high sensitive C-reactive protein, most pronounced in subjects with best adherence to the diet (all r values < −0.8; all P values <0.05). Levels of brain-derived neurotrophic factor remained unchanged. No significant memory changes were observed in the other 2 groups. This interventional trial demonstrates beneficial effects of caloric restriction on memory performance in healthy elderly subjects. Mechanisms underlying this improvement might include higher synaptic plasticity and stimulation of neurofacilitatory pathways in the brain because of improved insulin sensitivity and reduced inflammatory activity. Our study may help to generate novel prevention strategies to maintain cognitive functions into old age

show abstract

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Caloric restriction improves memory in elderly humans

Witte¹,

Fobker²,

Gellner³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

496

378

View full text Add to dashboard Cite

show abstract

“…To create a lifestyle score as described in previous studies (Floel et al, 2008;Kurth et al, 2006), we considered selfreported lifestyle information from a detailed questionnaire incorporating information about body mass index (BMI), dietary habits, exercise, smoking, and alcohol consumption. The overall 'lifestyle score' was calculated by assigning scores of 1-5 to each individual variable category, for which a higher point value indicates a healthier behavior.…”

Section: Lifestyle Indexmentioning

confidence: 99%

“…The healthiest behavior was defined as a BMI of 18.5-22 kg/m 2 , never smoking, intense physical activity (413 000 kcal per week), moderate alcohol consumption (4-10 drinks per week), and a dietary pattern rich in fruits, vegetables, wholegrain products, and unsaturated fatty acids. For details on this score, please see Floel et al (2008).…”

Section: Lifestyle Indexmentioning

confidence: 99%

Impact of Common KIBRA Allele on Human Cognitive Functions

Wersching

Guske

Hasenkamp

et al. 2011

Neuropsychopharmacol

View full text Add to dashboard Cite

The rs17070145 polymorphism (C-T substitution, intron 9) of the KIBRA gene has recently been associated with episodic memory and cognitive flexibility. These findings were inconsistent across reports though, and largely lacked gene-gene or gene-environment interactions. The aim of the present study was to determine the impact of the rs17070145 polymorphism on clinically relevant cognitive domains and its interaction with the modifiers 'lifestyle' and 'cardiovascular risk factors'. Five-hundred forty-five elderly volunteers (mean age 64 years, ± 7 years, 56% women) accomplished a comprehensive cognitive testing. Principal component analysis was used to reveal the internal structure of the data, rendering four composite scores: verbal memory, word fluency, executive function/psychomotor speed, and working memory. Lifestyle was assessed with a detailed questionnaire, age-associated risk factors by clinical interview and examination. There was no main effect of the rs17070145 genotype on any cognitive composite scores. However, we found worse performance in executive functions for T-allele carriers in the presence of arterial hypertension (b ¼ À0.365, p ¼ 0.0077 and 0.031 after Bonferroni correction). This association was further modified by gender, showing the strongest association in hypertensive females (b ¼ À0.500, p ¼ 0.0072 and 0.029 after Bonferroni correction). The effect of KIBRA on cognitive function seems to be complex and modified by gender and arterial hypertension.

show abstract

“…The relationship between physical activity and cognitive function is intriguing but remains undetermined [3,4]. There are some indications that physical activity may protect against the occurrence of cognitive decline in nondemented subjects [5].…”

Section: Introductionmentioning

confidence: 99%

Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX Trial): Rationale and Design

et al. 2013

View full text Add to dashboard Cite

Background: Exercise is hypothesized to improve cognition, physical performance, functional ability and quality of life, but evidence is scarce. Previous studies were of short duration, often underpowered and involving home-based light exercise programs in patients with undefined dementia. The aim of the ADEX (‘Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: the Effect of Physical Exercise') trial is to establish whether aerobic exercise is effective in improving cognition as well as in reducing the prevalence of psychiatric symptoms among patients with Alzheimer's disease (AD). Methods: The ADEX study is a multicenter, single-blind, randomized trial with two arms: an intervention group attending 16 weeks of continuously supervised moderate-to-high intensity aerobic exercise and a control group receiving usual care. We plan to recruit 192 patients with mild AD. The primary outcome measure is change from baseline in cognitive performance at 16 weeks (as measured by the Symbol Digit Modalities test). Conclusions: To our knowledge this is the first large-scale controlled study to investigate the effects of supervised moderate aerobic exercise on cognition in patients with AD. Recruitment began in January 2012 and results are expected to be available in 2014. We summarize the methodological challenges we and other studies have faced in this type of complex multicenter intervention with unique challenges to study design.

show abstract

Lifestyle and Memory in the Elderly

Cited by 52 publications

References 153 publications

Caloric restriction improves memory in elderly humans

Caloric restriction improves memory in elderly humans

Impact of Common KIBRA Allele on Human Cognitive Functions

Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX Trial): Rationale and Design

Contact Info

Product

Resources

About