Lifestyle Behavior Interventions for Preventing Cancer in Adults with Inherited Cancer Syndromes: Systematic Review

Serna, Celia de los Ríos de Diez la; Fernández, Paz; Lluch‐Canut, Teresa

doi:10.3390/ijerph192114098

Cited by 2 publications

(1 citation statement)

References 51 publications

(110 reference statements)

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“…Regardless, the WCRF score has been associated with all-cause and site-specific cancer incidence and mortality in the general population, so behavioural interventions to increase adherence to these criteria may still have substantial benefit for those with LS. However, a systematic review of 4 randomised trials of behavioural intervention in people with genetic tumour syndromes showed mixed results [55]. One randomised trial included investigated the effect of providing WCRF health promotion materials in people with LS [56].…”

Section: Discussionmentioning

confidence: 99%

Modifiable risk factors for cancer among people with lynch syndrome: an international, cross-sectional survey

Power,

Doherty,

Horgan

et al. 2024

Hered Cancer Clin Pract

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Background Lynch syndrome is the most common cause of hereditary colorectal and endometrial cancer. Lifestyle modification may provide an opportunity for adjunctive cancer prevention. In this study, we aimed to characterise modifiable risk factors in people with Lynch syndrome and compare this with international guidelines for cancer prevention. Methods A cross-sectional study was carried out utilizing survey methodology. Following public and patient involvement, the survey was disseminated through patient advocacy groups and by social media. Self-reported demographic and health behaviours were collected in April 2023. Guidelines from the World Cancer Research Fund (WCRF) were used to compare percentage adherence to 9 lifestyle recommendations, including diet, physical activity, weight, and alcohol intake. Median adherence scores, as a surrogate for lifestyle risk, were calculated and compared between groups. Results 156 individuals with Lynch syndrome participated from 13 countries. The median age was 51, and 54% were cancer survivors. The mean BMI was 26.7 and the mean weekly duration of moderate to vigorous physical activity was 90 min. Median weekly consumption of ethanol was 60 g, and 3% reported current smoking. Adherence to WCRF recommendations for cancer prevention ranged from 9 to 73%, with all but one recommendation having < 50% adherence. The median adherence score was 2.5 out of 7. There was no significant association between median adherence scores and age (p = 0.27), sex (p = 0.31), or cancer history (p = 0.75). Conclusions We have characterised the modifiable risk profile of people living with Lynch syndrome, outlining targets for intervention based on lifestyle guidelines for the general population. As evidence supporting the relevance of modifiable factors in Lynch syndrome emerges, behavioural modification may prove an impactful means of cancer prevention.

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Section: Discussionmentioning

confidence: 99%