Lifestyle changes and breast cancer prognosis: a review

Kellen, Eliane; Vansant, Greet; Christiaens, Marie-Rose; Neven, Patrick; Limbergen, Erik

doi:10.1007/s10549-008-9990-8

Cited by 62 publications

(46 citation statements)

References 78 publications

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“…Unhealthy lifestyle habits were more prevalent among the rural population with low level of education (Saiedi et al, 2006). Despite strong evidence suggesting that regular physical activity can protect against breast cancer (Thune et al, 2001;Kellen et al, 2008), only 23% and 12% of the subjects of this study had moderate and high physical activity levels respectively. Majority of the women (65%) had low level of physical activity and reported lack of exercise.…”

Section: N=100) Impact Of Healthy Eating Practices and Physical Activcontrasting

confidence: 81%

Impact of Healthy Eating Practices and Physical Activity on Quality of Life among Breast Cancer survivors

Mohammadi

Sulaiman²,

Koon³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Following breast cancer diagnosis, women often attempt to modify their lifestyles to improve their health and prevent recurrence. These behavioral changes typically involve diet and physical activity modification. The aim of this study was to determine association between healthy eating habits and physical activity with quality of life among Iranian breast cancer survivors. A total of 100 Iranian women, aged between 32 to 61 years were recruited to participate in this cross-sectional study. Eating practices were evaluated by a validated questionnaire modified from the Women's Healthy Eating and Living (WHEL) study. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). A standardized questionnaire by the European Organization of Research and Treatment of Cancer Quality of Life and its breast cancer module (EORTC QLQ-C30/+BR-23) were applied to determine quality of life. Approximately 29% of the cancer survivors were categorized as having healthy eating practices, 34% had moderate eating practices and 37% had poor eating practices based on nutrition guidelines. The study found positive changes in the decreased intake of fast foods (90%), red meat (70%) and increased intake of fruits (85%) and vegetables (78%). Generally, breast cancer survivors with healthy eating practices had better global quality of life, social, emotional, cognitive and role functions. Results showed that only 12 women (12%) met the criteria for regular vigorous exercise, 22% had regular moderate-intensity exercise while the majority (65%) had low-intensity physical activity. Breast cancer survivors with higher level of physical activity had better emotional and cognitive functions. Healthy eating practices and physical activity can improve quality of life of cancer survivors. Health care professionals should promote good dietary habits and physical activity to improve survivors' health and quality of life.

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Section: N=100) Impact Of Healthy Eating Practices and Physical Activcontrasting

confidence: 81%

Impact of Healthy Eating Practices and Physical Activity on Quality of Life among Breast Cancer survivors

Mohammadi

Sulaiman²,

Koon³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The association between obesity and poor overall survival [18,[24][25][26] or prognosis of breast cancer [17,[27][28][29], might, if also true for BRCA1/2 carriers, have influenced our study results. The inclusion of prevalent cases, may have led toward bias to the null, overweight/obese prevalent cases may have been underrepresented because they had died prior to study entry [24,27,28].…”

Section: Discussionmentioning

confidence: 88%

“…Previous studies showed that excess body weight (defined as overweight (BMI between 25.0 and 29.9 kg/m 2 ) or obesity (BMI C 30.0 kg/m 2 ) decreases overall survival [18,[24][25][26] and breast cancer-specific survival [17,[27][28][29]. The association between obesity and poor prognosis of breast cancer was present in both pre-and postmenopausal carriers.…”

Section: Analytic Cohortmentioning

confidence: 99%

Body weight and risk of breast cancer in BRCA1/2 mutation carriers

Manders

Pijpe²,

Hooning

et al. 2010

Breast Cancer Res Treat

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Obesity is an established risk factor for postmenopausal breast cancer in the general population. However, it is still unclear whether this association also exists in BRCA1/2 mutation carriers. We investigated the association between self-reported anthropometric measures and breast cancer risk in a nationwide retrospective cohort study, including 719 BRCA1/2 carriers, of whom 218 had been diagnosed with breast cancer within 10 years prior to questionnaire completion. All time-varying Cox proportional hazards analyses were stratified by menopausal status. For premenopausal breast cancer, no statistically significant associations were observed for any of the anthropometric measures. The association between body mass index (BMI) at age 18 and premenopausal breast cancer risk suggested a trend of decreasing risk with increasing BMI 123Breast Cancer Res Treat (2011) 126:193-202 DOI 10.1007/s10549-010-1120 5 kg or more, and a relative adult weight gain of 20% or more were all non-significantly associated with a 50-60% increased risk of postmenopausal breast cancer [HR = 1.46 (0.86-2.51), HR = 1.56 (95% CI = 0.85-2.87), and HR = 1.60 (95% CI = 0.97-2.63), respectively], when compared with having a healthy or stable weight. No associations for body weight or BMI at age 18 were observed. In conclusion, menopausal status seemed to modify the association between body weight and breast cancer risk among BRCA1/2 carriers. We observed no clear association between body weight and premenopausal breast cancer, while overweight and weight gain increased postmenopausal breast cancer risk. Carriers may reduce their risk of postmenopausal breast cancer by maintaining a healthy body weight throughout life.

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“…Physical activity is related to overall survival [19,20] and breast cancer-related survival [21][22][23]. Consequently, in this study population of women at high risk of cancer death, prevalent cases that were relatively active may have been overrepresented in our entire cohort, leading to bias toward unity (assuming physical activity reduces breast cancer risk).…”

Section: Analytic Cohortmentioning

confidence: 96%

Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers

Pijpe

Manders

Brohet

et al. 2009

Breast Cancer Res Treat

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BRCA1/2 mutation carriers have a high lifetime risk of developing breast cancer. Differences in penetrance indicate that this risk may be influenced by lifestyle factors. Because physical activity is one of the few modifiable risk factors, it may provide a target to add to breast cancer prevention in this high-risk population. We examined the association between self-reported lifetime sports activity and breast cancer risk in a nationwide retrospective cohort study, including 725 carriers, of whom 218 had been diagnosed with breast cancer within 10 years prior to questionnaire completion. We found a nonsignificantly decreased risk for ever engaging in sports activity (HR = 0.84, 95%CI = 0.57-1.24). Among women who had participated in sports, a medium versus low level of intensity and duration (i.e., between 11.0 and 22.7 mean MET hours/week averaged over a lifetime) reduced the risk of breast cancer (HR = 0.59, 95%CI = 0.36-0.95); no dose-response trend was observed. For mean hours/week of sports activity, a nonsignificant trend was observed (HR low versus never = 0.93, 95%CI = 0.60-1.43; HR medium versus never = 0.81, 95%CI = 0.51-1.29; HR high versus never = 0.78, 95%CI = 0.48-1.29; p trend overall = 0.272; p trend active women = 0.487). For number of years of sports activity no significant associations were found. Among women active in sports before age 30, mean MET hours/week showed the strongest inverse association of all activity measures (HR medium versus low = 0.60, 95%CI = 0.38-0.96; HR high versus low = 0.58, 95%CI = 0.35-0.94; p trend = 0.053). Engaging in sports activity after age 30 was also inversely associated with breast cancer risk (HR = 0.63, 95%CI = 0.44-0.91). Our results indicate that sports activity may reduce the risk of breast cancer in BRCA1/2 mutation carriers.

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Lifestyle changes and breast cancer prognosis: a review

Cited by 62 publications

References 78 publications

Impact of Healthy Eating Practices and Physical Activity on Quality of Life among Breast Cancer survivors

Impact of Healthy Eating Practices and Physical Activity on Quality of Life among Breast Cancer survivors

Body weight and risk of breast cancer in BRCA1/2 mutation carriers

Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers

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