Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study

Michaud, Dominique S.; Izard, Jacques; Rubin, Zachary; Johansson, Ingegerd; Weiderpass, Elisabete; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie Christine; Clavel‐Chapelon, Françoise; Dossus, Laure; Kaaks, Rudolf; Katzke, Verena; Boeing, Heiner; Foerster, Jana; Trichopoulou, Antonia; Naska, Androniki; G, Ziara; Víneis, Paolo; Grioni, Sara; Palli, Domenico; Tumino, Rosario; Mattiello, Amalia; Peeters, Petra H.M.; Siersema, Peter D.; Barricarte, Aurelio; Huerta, José María; Molina‐Montes, Esther; Dorronsoro, Miren; Quiŕos, J. Ramón; Duell, Eric J.; Ohlsson, Bodil; Jeppsson, Bengt; Johansson, Anders; Lif, Pernilla; Khaw, Kay Tee; Wareham, Nick; Travis, Ruth C.; Key, Tim; Freisling, Heinz; Duarte‐Salles, Talita; Stępień, Magdalena; Riboli, Elio; Bueno-De-Mesquita, H. Bas

doi:10.1007/s10552-013-0265-2

Cited by 24 publications

(20 citation statements)

References 33 publications

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“…In our study we sought to avoid the influence of smoking (within one year) and antibiotic use (within 30 days) by exclusion criteria. A number of studies have reported that smokers and non-smokers differ in the oral microbiota [33–35] and other aspects of oral health [36,37]. Differences between smokers and non-smokers have also been noted in studies of the microbiota at other sites [38,39].…”

Section: Discussionmentioning

confidence: 99%

The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study

Olson

Satagopan

et al. 2017

Cancer Causes Control

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Purpose Poor oral health appears to be a risk factor for pancreatic cancer, possibly implicating the oral microbiota. In this pilot study, we evaluated the characteristics of the oral microbiota in patients with pancreatic ductal adenocarcinoma (PDAC), intraductal papillary mucinous neoplasms (IPMN), and healthy controls. Methods Forty newly diagnosed PDAC patients, 39 IPMN patients, and 58 controls, excluding current smokers and users of antibiotics, provided saliva samples. Common oral bacterial species were comprehensively surveyed by sequencing of the 16S rRNA microbial genes. We obtained measures of diversity and the mean relative proportions of individual taxa. We explored the degree to which these measures differed according to respondent characteristics based on individual interviews. Results PDAC cases did not differ in diversity measures from either controls or IPMN cases. PDAC cases had higher mean relative proportions of Firmicutes and related taxa, while controls had higher mean relative proportions of Proteobacteria and related taxa. Results were generally similar when comparing PDAC to IPMN cases. Among IPMNs and controls combined, younger individuals had higher levels of several taxa within the Proteobacteria. The only other variable consistently related to mean relative proportions was mouthwash use, with taxa within Firmicutes more common among users. Conclusions While there were no differences in diversity of the oral microbiota among these groups, there were differences in the mean relative proportions of some taxa. Characteristics of the oral microbiota are not associated with most measures of oral health.

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Section: Discussionmentioning

confidence: 99%

The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study

Olson

Satagopan

et al. 2017

Cancer Causes Control

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“…Smokers’ microbiomes have less diversity, higher prevalence of organisms associated with periodontal pathogenesis and lower prevalence of those associated with health (22,55). There is evidence of lower humoral immune response in both current and former smokers compared to never smokers (56). Our finding of increased breast cancer risk associated with periodontal disease among former smokers who had quit in the past 20 years could be an indication that previous exposure to smoking was significant in the carcinogenic process or that the smoking resulted in a change slow to be reversed.…”

Section: Discussionmentioning

confidence: 99%

Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women

Freudenheim

Genco

LaMonte

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Periodontal disease (PD) has been consistently associated with chronic disease; there are no large studies of breast cancer although oral-associated microbes are present in breast tumors. Methods In the Women’s Health Initiative Observational Study, a prospective cohort of postmenopausal women, 73,737 women without previous breast cancer were followed. Incident, primary, invasive breast tumors were verified by physician adjudication. PD was by self-report. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox proportional hazards, adjusted for breast cancer risk factors. Because the oral microbiome of those with PD differs with smoking status, we examined associations stratified by smoking. Results 2,124 incident, invasive breast cancer cases were identified after mean follow-up of 6.7 years. PD, reported by 26.1% of women, was associated with increased breast cancer risk (HR 1.14, 95% CI 1.03 to 1.26), particularly among former smokers who quit within 20 years (HR 1.36; 95% CI 1.05 to 1.77). Among current smokers, the trend was similar (HR 1.32; 95% CI 0.83 to 2.11); there were few cases (n=74) and the CI included the null. The population attributable fraction was 12.06% (95% CI 1.12 to 21.79) and 10.90% (95% CI 10.31 to 28.94) for PD among former smokers quitting within 20 years and current smokers, respectively. Conclusion PD, a common chronic inflammatory disorder, was associated with increased risk of postmenopausal breast cancer, particularly among former smokers who quit in the past 20 years. Impact Understanding a possible role of the oral microbiome in breast carcinogenesis could impact prevention.

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“…Tobacco smoking has been observed to affect the peripheral immune system through various changes, including a decrease in the activity of natural killer cells, increase in white blood cell counts, and a higher susceptibility to infection [25]. In a study which ascertained plasma antibodies to specific oral bacteria in 395 cancer-free participants, current smokers tended to have lower antibody levels to oral bacteria than never smokers [26]. Similarly, in a sample of 8,153 participants from NHANES III, smokers tended to have lower antibody levels to nine specific periodontal bacteria, but had higher titers to Micromonas micros [27].…”

Section: Discussionmentioning

confidence: 99%

Association between tobacco use and the upper gastrointestinal microbiome among Chinese men

Vogtmann

Flores

et al. 2015

Cancer Causes Control

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Purpose Tobacco causes many adverse health conditions and may alter the upper gastrointestinal (UGI) microbiome. However, the few studies that studied the association between tobacco use and the microbiome were small and underpowered. Therefore, we investigated the association between tobacco use and the UGI microbiome in Chinese men. Methods We included 278 men who underwent esophageal cancer screening in Henan Province, China. Men were categorized as current, former, or never smokers from questionnaire data. UGI tract bacterial cells were characterized using the Human Oral Microbial Identification Microarray. Counts of unique bacterial species and genera estimated alpha diversity. For beta diversity, principal coordinate (PCoA) vectors were generated from an unweighted UniFrac distance matrix. Polytomous logistic regression models were used for most analyses. Results Of the 278 men in this study, 46.8% were current smokers and 12.6% were former smokers. Current smokers tended to have increased alpha diversity (mean: 42.3 species) compared to never smokers (mean: 38.9 species). For a 10 species increase, the odds ratio (OR) for current smoking was 1.29 (95% CI: 1.04–1.62). Beta diversity was also associated with current smoking. The first two PCoA vectors were strongly associated with current smoking (PCoA1 OR 0.66; 95% CI: 0.51–0.87; PCoA2 OR 0.73; 95% CI: 0.56–0.95). Furthermore, Dialister invisus and Megasphaera micronuciformis were more commonly detected in current smokers than in never smokers. Conclusions Current smoking was associated with both alpha and beta diversity in the UGI tract. Future work should consider how the UGI microbiome is associated with smoking related diseases.

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Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study

Cited by 24 publications

References 33 publications

The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study

The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study

Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women

Association between tobacco use and the upper gastrointestinal microbiome among Chinese men

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