Lifestyle, Environment, and Male Reproductive Health

“…Более 30 % случаев бесплодия у муж-чин относят к идиопатическим нарушениям с невыяс-ненной этиологией [6]. В этой связи особое значение приобретают исследования, направленные на выяс-нение факторов риска развития идиопатического бес-плодия, к числу которых относят факторы образа жиз-ни и окружающей среды [7][8][9].…”

Section: Abstract: Male Infertility Risk Factor Of Infertility Obeunclassified

“…[8]. Также к факторам риска мужского бесплодия относят использование мобильных телефонов, анабо-лических стероидов, опиоидов и марихуаны и даже глобальное потепление [9].…”

Section: Abstract: Male Infertility Risk Factor Of Infertility Obeunclassified

Sociomedical risk factors for male infecundity

Епанчинцева¹,

Селятицкая²,

Свиридова³

et al. 2016

Androl. genit. hir.

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“…This advocates that environmental risk factors may have a higher precedence than genetic associations in determining risk of prostate cancer. Furthermore, environmental and lifestyle factors, diet in particular, fundamentally alter endogenous hormones including sex steroids (Barazani et al 2014). Indeed, factors such as smoking, increased physical exercise and a vegetarian diet increased serum androgen concentrations in British men, while obesity, high-fat diet and sedentary occupation reduced serum androgen concentrations (Allen et al 2002).…”

Section: Introductionmentioning

confidence: 99%

In touch with your feminine side: how oestrogen metabolism impacts prostate cancer

Rahman

Hofland

Foster

2016

Endocrine-Related Cancer

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Prostate cancer is the primary cancer in males, with increasing global incidence rates making this malignancy a significant healthcare burden. Androgens not only promote normal prostate maturity but also influence the development and progression of prostate cancer. Intriguingly, evidence now suggests endogenous and exogenous oestrogens, in the form of phytoestrogens, may be equally as relevant as androgens in prostate cancer growth. The prostate gland has the molecular mechanisms, catalysed by steroid sulphatase (STS), to unconjugate and utilise circulating oestrogens. Furthermore, prostate tissue also expresses enzymes essential for local oestrogen metabolism, including aromatase (CYP19A1) and 3β- and 17β-hydroxysteroid dehydrogenases. Increased expression of these enzymes in malignant prostate tissue compared with normal prostate indicates that oestrogen synthesis is favoured in malignancy and thus may influence tumour progression. In contrast to previous reviews, here we comprehensively explore the epidemiological and scientific evidence on how oestrogens impact prostate cancer, particularly focusing on pre-receptor oestrogen metabolism and subsequent molecular action. We analyse how molecular mechanisms and metabolic pathways involved in androgen and oestrogen synthesis intertwine to alter prostate tissue. Furthermore, we speculate on whether oestrogen receptor status in the prostate affects progression of this malignancy.

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Lifestyle, Environment, and Male Reproductive Health

Cited by 100 publications

References 83 publications

Kesan Psikostres terhadap Kerosakan DNA dan Ketaknormalan Titisan Sitoplasma Sperma Manusia

Kesan Psikostres terhadap Kerosakan DNA dan Ketaknormalan Titisan Sitoplasma Sperma Manusia

Sociomedical risk factors for male infecundity

In touch with your feminine side: how oestrogen metabolism impacts prostate cancer

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