Lifestyle factors and risk for colorectal polyps and cancer at index colonoscopy in a FIT‐positive screening population

Colussi, Dora; Fabbri, Margherita; Zagari, Rocco Maurizio; Montale, Amedeo; Bazzoli, Franco; Ricciardiello, Luigi

doi:10.1177/2050640618764711

Cited by 18 publications

(20 citation statements)

References 28 publications

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“…Obesity has been strongly associated with precancerous lesions and conditions such as colon adenomas [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86], monoclonal gammopathy [87][88][89][90][91][92][93][94][95][96][97][98], chronic pancreatitis [99][100][101][102], or inflammatory bowel disease (IBD) [103][104][105][106]. Observed risks of cancers associated with obesity include breast [107][108][109][110][111], colorectal [112][113][114][115], pancreatic [99]…”

Section: Morbid Obesitymentioning

confidence: 99%

Microbiome and morbid obesity increase pathogenic stimulus diversity

Brücher

Jamall

2019

4open

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The microbiome, the relationship between environmental factors, a high-fat diet, morbid obesity, and host response have been associated with cancer, only a small fraction of which (<10%) are genetically triggered. This nongenetic association is underpinned by a worldwide increase in morbid obesity, which is associated with both insulin resistance and chronic inflammation. The connection of the microbiome and morbid obesity is reinforced by an approximate shift of about 47% in the estimated total number of bacteria and an increase from 38,000,000,000,000 in a reference man to 56,000,000,000,000 in morbid obesity leading to a disruption of the microbial ecology within the gut. Humans contain 6,000,000,000 microbes and more than 90% of the cells of the human body are microorganisms. Changes in the microflora of the gut are associated with the polarization of ion channels by butyrate, thereby influencing cell growth. The decrease in the relative proportion of Bacteroidetes together with a change in the fermentation of carbohydrates by bacteria is observed in morbid obesity. The disruption of homeostasis of the microflora in the obese changes signaling and crosstalk of several pathways, resulting in inflammation while suppressing apoptosis. The interactions between the microbiome and morbid obesity are important to understand signaling and crosstalk in the context of the progression of the six-step sequence of carcinogenesis. This disruption of homeostasis increases remodeling of the extracellular matrix and fibrosis followed by the none-resolvable precancerous niche as the internal pathogenic stimuli continue. The chronic stress explains why under such circumstances there is a greater proclivity for normal cells to undergo the transition to cancer cells.

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Section: Morbid Obesitymentioning

confidence: 99%

Microbiome and morbid obesity increase pathogenic stimulus diversity

Brücher

Jamall

2019

4open

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“…Even with the continuous exploration of its research, the disease has not been fully understood. 6, 7 The evaluation of malignancy degree and prognosis of colorectal cancer is of great significance in clinical work. At present, the evaluation of malignancy degree of colorectal cancer mainly comes from TNM stage, which refers to some pathologic indicators after surgery, including whether to penetrate serosa, lymph node metastasis, other organ metastasis and peripheral adhesion.…”

Section: Introductionmentioning

confidence: 99%

Combining Red Blood Cell Distribution Width (RDW-CV) and CEA Predict Poor Prognosis for Survival Outcomes in Colorectal Cancer

Xing

et al. 2019

J. Cancer

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Background : Colorectal cancer is one of the common tumors that seriously threaten human health worldwide. Serum tumor markers, including CEA and CA19-9, have become the focus of research on colorectal cancer in recent years. As one of the classic blood test results, RDW is related to the pathological features, diagnosis and prognosis of various cancers in recent studies. We hope to search the correlation between RDW and the pathological features of colorectal cancer through the following studies, explore the potential relationship between RDW and the prognosis of colorectal cancer, and find a more effective prognostic evaluation method by combining other blood markers. Methods : We retrospectively analyzed 168 patients with colorectal cancer included in this study, collected their clinical data, tumor pathological features and their preoperative blood test results including RDW value and tumor markers, and grouped them. After 3 and 5 years of follow-up, the recurrence and survival status were defined, and the above data were statistically analyzed. Results : The distribution frequency/rate of abnormal RDW-CV in colorectal cancer patients was significantly increased in the elderly (>62), colon cancer, serosal permeability, lymph node metastasis, stage III and IV, peripheral adhesion (P < 0.05). Furthermore, RDW-CV was significantly positively correlated with abnormal high values of tumor serum markers CEA and CA19-9 (P < 0.05). More importantly, ROC curve analysis found that the abnormal increase in RDW-CV in colorectal cancer was associated with the shortening of DFS and OS in patients who were followed up for 3 and 5 years (P < 0.05). Further combined with CEA, it was found that the prognosis and survival of patients with colorectal cancer in 3 and 5 years were more accurate and effective than independent prediction (AUC of DFS in 3/5years=0.630/0.635, AUC of OS in 3/5 years=0.692/0.652). Conclusion : RDW-CV is correlated with the pathological features of colorectal cancer, indicating a worse malignant tendency of tumor. RDW-CV can independently evaluate the prognosis of colorectal cancer patients, and combined with the high value of CEA, it can effectively indicate the adverse recurrence and survival prognosis.

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“…The incidence of EOCRC has been on the rise over the past four decades and it is expected to increase by >140% by 2030. At present, different established cancer drivers have been linked to EOCRC including diet, sedentary lifestyle, smoking, and alcohol [ 63 ]. The gut microbiota is probably at the intersection of these risk factors and EOCRC.…”

Section: Lifestyle Diet and Microbiota In The Early Onset Of Crcmentioning

confidence: 99%

Gut Microbiota Manipulation as a Tool for Colorectal Cancer Management: Recent Advances in Its Use for Therapeutic Purposes

Perillo

Amoroso

Strati

et al. 2020

IJMS

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Colorectal cancer (CRC) is a multifaceted disease influenced by both environmental and genetic factors. A large body of literature has demonstrated the role of gut microbes in promoting inflammatory responses, creating a suitable microenvironment for the development of skewed interactions between the host and the gut microbiota and cancer initiation. Even if surgery is the primary therapeutic strategy, patients with advanced disease or cancer recurrence after surgery remain difficult to cure. Therefore, the gut microbiota has been proposed as a novel therapeutic target in light of recent promising data in which it seems to modulate the response to cancer immunotherapy. The use of microbe-targeted therapies, including antibiotics, prebiotics, live biotherapeutics, and fecal microbiota transplantation, is therefore considered to support current therapies in CRC management. In this review, we will discuss the importance of host−microbe interactions in CRC and how promoting homeostatic immune responses through microbe-targeted therapies may be useful in preventing/treating CRC development.

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Lifestyle factors and risk for colorectal polyps and cancer at index colonoscopy in a FIT‐positive screening population

Cited by 18 publications

References 28 publications

Microbiome and morbid obesity increase pathogenic stimulus diversity

Microbiome and morbid obesity increase pathogenic stimulus diversity

Combining Red Blood Cell Distribution Width (RDW-CV) and CEA Predict Poor Prognosis for Survival Outcomes in Colorectal Cancer

Gut Microbiota Manipulation as a Tool for Colorectal Cancer Management: Recent Advances in Its Use for Therapeutic Purposes

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