Lifestyle factors and the risk associated with conventional adenomas and serrated polyps among healthy people undergoing a medical checkup

Abstract

Background: The association between lifestyle factors and the risk of colon adenomas and serrated polyps (SPs) in the in asymptomatic healthy people is unclear. Aims: The aim of this study was to explore and compare the lifestyle-related risk factors related to colon adenomas and SPs on average-risk individuals. Methods: A total of 5736 subjects，namely, 4346 men (75.77%) and 1390 women (24.23%), with an average age of 48.60 ± 7.29 years were included. Subjects underwent colonoscopy and provided diet and lifestyle data for 5 years. Results: We documented the data of 555 conventional adenomas, 324 SPs, and 95 synchronous adenomas and SPs. Logistic regression analysis indicated smoking, middle age, overweight and high education level was common risk factors for adenomas and SPs. Smokers were more likely to develop adenomas (OR: 1.41, 95%CI: 1.29-1.54) and SPs (OR: 1.62, 95%CI: 1.46-1.81), respectively. The risk of adenomas and SPs in middle-aged adults was 1.92 (OR: 1.92, 95%CI: 1.55-2.37) and 1.36 fold (OR: 1.36, [95%CI: 1.07-1.73]) compared with young adults, respectively. SPs were more strongly correlated with BMI than adenomas (P<0.05). Those with a high educational background had a higher risk of conventional adenomas (OR: 1.13, 95% CI: 0.99-1.29) and SPs (OR: 1.13, 95% CI: 0.96-1.31) compared to individuals with a low educational background. Men and fasting blood glucose ≥ 7.0 mmol/L were associated with higher risk of adenomas. Conclusions: Lifestyle risk factors have different association with adenomas or SPs. These findings provide new clues for the prevention of colorectal polyps.