Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project

Galbete, Cecilia; Toledo, Jon B.; Martínez‐González, Miguel Ángel; Martínéz, J. Alfredo; Guillén-Grima, Francisco; Marti, Amelia

doi:10.1007/s12263-012-0296-4

Cited by 26 publications

(18 citation statements)

References 45 publications

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“…A report on elderly university alumni from Spain, the SUN study, found that FTO associations with obesity-risk might depend on high carbohydrate intake [22]. If we take into account the BMI of study participants when they are young for genetic association analyses, we could begin to understand the accumulative effect of lifestyle events.…”

Section: Discussionmentioning

confidence: 99%

FTO genotype is associated with body mass index and waist circumference in Mexican young adults

Terán-García¹,

Vázquez-Vidal²,

Andrade

et al. 2013

OJGen

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Individual variations in the fat mass and obesityassociated (FTO) gene have been associated with obesity and BMI in diverse populations, but there are no reports in young Mexicans. We explored the association of a common FTO single-nucleotide polymorphism (SNP, rs805704) with obesity-related phenotypes in Mexican young adults. The FTO-SNP was genotyped using the fluorescent polarization method in college-age, apparently healthy subjects from the "UP AMIGOS" cohort (n = 251, 18 -25 yrs). Homozygotes for the A allele (15%, n = 38) were heavier (1.6 kg/m 2 and 6.2 kg) and had a larger waist circumference (WC, 4.8 cm) than G allele carriers. The FTO genotype was associated with BMI, weight and WC independently of age and sex and explained 2.7 to 3.1% of the variance in obesity-related phenotypes. The FTO genotype was also associated with fasting glucose (P = 0.0283). No other associations were found in the additive model. Despite our small sample size, we found that the FTO-rs805704 genotype influences obesity-related phenotypes young Mexicans. Previously observed FTO associations with fasting glucose were replicated. Previously reported associations with other metabolic traits likely represent the long-term consequences of obesity.

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Section: Discussionmentioning

confidence: 99%

FTO genotype is associated with body mass index and waist circumference in Mexican young adults

Terán-García¹,

Vázquez-Vidal²,

Andrade

et al. 2013

OJGen

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“…The risk allele 12Ala has been linked to increased obesity risk through meta-analysis, although some heterogeneous effects of this mutation have also been observed in interaction studies [148][149][150]. Lamri et al [151] analysed the interaction between PPARG Pro12Ala polymorphism and fat intake, and observed that AlaAla individuals displayed greater BMI values than Pro carriers among high fat consumers.…”

Section: Obesity-predisposing Gene Variants Interact With Dietmentioning

confidence: 99%

The importance of gene–environment interactions in human obesity

2016

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The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However, who becomes obese in an obesity-prone environment is largely determined by genetic factors. In the last 20 years, important progress has been made in the elucidation of the genetic architecture of obesity. In parallel with successful gene identifications, the number of gene-environment interaction (GEI) studies has grown rapidly. This paper reviews the growing body of evidence supporting gene-environment interactions in the field of obesity. Heritability, monogenic and polygenic obesity studies provide converging evidence that obesity-predisposing genes interact with a variety of environmental, lifestyle and treatment exposures. However, some skepticism remains regarding the validity of these studies based on several issues, which include statistical modelling, confounding, low replication rate, underpowered analyses, biological assumptions and measurement precision. What follows in this review includes (1) an introduction to the study of GEI, (2) the evidence of GEI in the field of obesity, (3) an outline of the biological mechanisms that may explain these interaction effects, (4) methodological challenges associated with GEI studies and potential solutions, and (5) future directions of GEI research. Thus far, this growing body of evidence has provided a deeper understanding of GEI influencing obesity and may have tremendous applications in the emerging field of personalized medicine and individualized lifestyle recommendations.

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“…It is widely recognised that there is an inverse relationship between obesity and physical activity practice ( Levine 2005;Galbete et al, 2012;Kilpelainen et al, 2011). In fact, some studies have revealed association between genetic variants and physical activity (Galbete et al, 2012;Kilpelainen et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…In fact, some studies have revealed association between genetic variants and physical activity (Galbete et al, 2012;Kilpelainen et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Physical Activity and Sex Modulate Obesity Risk Linked to 3111T/C Gene Variant of theCLOCKGene in an Elderly Population: The SUN Project

Galbete

Contreras

Martínez

et al. 2012

Chronobiology International

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Genetic factors may interact with physical activity levels to modify obesity risk. Our aim was to explore the effect of rs1801260 SNP (3111T/C) of CLOCK gene, on obesity risk and to examine their interaction with lifestyle factors in an elderly population of the SUN Project. Subjects (n=903, aged 69±6) were recruited from the SUN ("Seguimiento Universidad de Navarra") Project. DNA was obtained from saliva and lifestyle and dietary data were collected by validated self-reported questionnaires. Genotyping was assessed by RT-PCR plus allele discrimination. A significant interaction between the 3111T/C SNP of CLOCK gene and sex for overweight/obesity risk was observed (p for interaction [Sex*CLOCK] interaction <0.001). Our results showed that women carrying the C allele of CLOCK gene had a decreased overweight/obesity risk compared to non carrier -TT-subjects (OR 0.61, 95% CI: 0.36-1.04, p=0.069). Moreover, the protective effect of the 3111T/C gene variant may be enhanced in those women with a high physical activity practice. We found that women practicing more than 16.8 METsh/week had a significantly lower overweight/obesity risk (OR 0.36, 95%CI: 0.17-0.79, p=0.011). A significant interaction between the 3111T/C gene variant and physical activity for overweight/obesity risk was observed in women (p for [PA x CLOCK] interaction=0.015). In conclusion, it appears that physical activity levels may act as an effect modifier for overweight/obesity risk linked to the 3111T/C SNP (rs1801260) of the CLOCK gene in an elderly population of the SUN Project.

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Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project

Cited by 26 publications

References 45 publications

FTO genotype is associated with body mass index and waist circumference in Mexican young adults

FTO genotype is associated with body mass index and waist circumference in Mexican young adults

The importance of gene–environment interactions in human obesity

Physical Activity and Sex Modulate Obesity Risk Linked to 3111T/C Gene Variant of theCLOCKGene in an Elderly Population: The SUN Project

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