Lifestyle habits as prognostic factors in survival of laryngeal and hypopharyngeal cancer: A multicentric European study

Dikshit, Rajesh; Boffetta, Paolo; Bouchardy, Christine; Merletti, Franco; Crosignani, Paolo; Cuchi, Teresa; Ardanáz, Eva; Brennan, Paul

doi:10.1002/ijc.21244

Cited by 80 publications

(78 citation statements)

References 9 publications

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“…2,21 Demographic factors such as age, sex, race, familial history of cancer, socioeconomic status, lifestyles, and habits (tobacco, alcohol, and substance abuse) are only a few of the many factors that impact outcomes of treatment. 13,14,22,23 Clinicians regularly use this information in the decision-making process for treatment of patients with cancer. However, none of the other host characteristics have representation in the current staging system for oral cancer.…”

Section: Discussionmentioning

confidence: 99%

Nomograms for preoperative prediction of prognosis in patients with oral cavity squamous cell carcinoma

Montero

Yu²,

Palmer

et al. 2013

Cancer

114

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BACKGROUND: This study sought to develop prognostic tools that will accurately predict overall and cancer-related mortality and risk of recurrence in individual patients with oral cancer based on host and tumor characteristics. These tools would take into account numerous prognosticators beyond those covered by the traditional TNM (tumor-node-metastasis) staging system. METHODS: Demographic, host, and tumor characteristics of 1617 patients with cancer of the oral cavity, who were treated primarily with surgery at a single-institution tertiary care cancer center between 1985 and 2009, were reviewed from a preexisting database. Recurrent disease was recorded in 509 patients (456 locoregional and 116 distant); 328 patients died of cancer-related causes, and 542 died of other causes. The median follow-up was 42 months (range, 1-300 months). The following variables were analyzed as predictors of prognosis: age, sex, race, alcohol and tobacco use, oral cavity subsite, invasion of other structures, comorbidity, tumor size, and clinical nodal status. The stepdown method was used to select the statistically most influential predictors for inclusion in the final nomogram for each outcome of interest. RESULTS: The most influential predictors of both recurrence and cancer-specific mortality probability (CSMP) were tumor size, nodal status, subsite, and bone invasion. Nomograms were generated for prediction of overall survival (OS), CSMP, and locoregional recurrence-free probability (LRRFP). The nomograms were internally validated with an overfit-corrected predictive discrimination metric (concordance index) for OS of 67%, CSMP of 66%, and LRRFP of 60%. CONCLUSIONS: Nomograms have been developed that can reasonably estimate OS, CSMP, and LRRFP based on specific tumor and host characteristics in patients with oral cancer. Cancer 2014;120:214-21.

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Section: Discussionmentioning

confidence: 99%

Nomograms for preoperative prediction of prognosis in patients with oral cavity squamous cell carcinoma

Montero

Yu²,

Palmer

et al. 2013

Cancer

114

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“…Results concerning patient survival and the occurrence of SPTs according to demographic and lifestyle factors recently have been published. 3,13 Surgical paraffin-embedded tissue (PET) sections were collected for the current study from 235 patients who had complete follow-up information available. The patients were comprised of 155 men and 12 women from the city of Turin, Italy, and 67 men and 1 woman from the province of Navarra, Spain.…”

Section: Study Populationmentioning

confidence: 99%

“…1 Previously, we described the role of clinical and lifestyle-related factors in the prognosis for patients with laryngeal and hypopharyngeal cancer. 2,3 Recent studies also have investigated the role played by genetic and epigenetic alterations in the progression to head and neck cancer 4,5 and, specifically, have analyzed the cytosine methylation of CpG islands in gene promoters. It has been suggested that aberrant promoter methylation is associated with loss of gene function that can provide a selective advantage for neoplastic cells, similar to what occurs in mutations.…”

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confidence: 99%

Hypermethylation, risk factors, clinical characteristics, and survival in 235 patients with laryngeal and hypopharyngeal cancers

Dikshit

Gillio-Tos

Brennan

et al. 2007

Cancer

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BACKGROUND.It has been established that promoter hypermethylation occurs in several genes during the pathogenesis of head and neck cancer. The authors investigated the role played by the hypermethylation of 4 cancer‐related genes in the survival of patients who had laryngeal and hypopharyngeal cancer and in the occurrence of second primary tumors.METHODS.Archival paraffin‐embedded tissue (PET) samples were available from patients who were enrolled in a multicentric European case‐control study that was performed between 1979 and 1982 and was followed up to 2000. Genomic DNA extracted from 235 PET samples were analyzed for promoter methylation status of the p16, O6‐methylguanine‐DNA methyltransferase (MGMT), death‐associated protein kinase (DAP‐K), and E‐cadherin genes by using a methylation‐specific polymerase chain reaction assay.RESULTS.Hypermethylation was present in 44% of samples for p16, in 27% of samples for MGMT, in 42% of samples for DAP‐K, and in 43% of samples for E‐cadherin. Hypermethylation of either individual genes or their combination was not associated with mortality from all causes, mortality from upper aerodigestive tract cancer, or the occurrence of second primary tumors.CONCLUSIONS.The analysis of a large series of patients with laryngeal and hypopharyngeal cancer suggested that hypermethylation is a frequent event in laryngeal and hypopharyngeal cancer, but it is not a predictor of mortality or second primary cancer. Cancer 2007. © 2007 American Cancer Society.

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“…Some studies report an inverse association between alcohol intake and survival,13, 19, 20, 21 whilst others have found little or no evidence of an effect 17, 22. Consequently, it is unclear whether any association of alcohol consumption with HNC cancer mortality is genuine, or the result of residual confounding by smoking (or other factors).…”

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confidence: 99%

Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all‐cause mortality: Results from head and neck 5000, a prospective observational cohort of people with head and neck cancer

Beynon

Lang

Schimansky

et al. 2018

Intl Journal of Cancer

136

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Tobacco smoking and alcohol consumption are well‐established risk factors for head and neck cancer. The prognostic role of smoking and alcohol intake at diagnosis have been less well studied. We analysed 1,393 people prospectively enrolled into the Head and Neck 5000 study (oral cavity cancer, n=403; oropharyngeal cancer, n=660; laryngeal cancer, n=330) and followed up for a median of 3.5 years. The primary outcome was all‐cause mortality. We used Cox proportional hazard models to derive minimally adjusted (age and gender) and fully adjusted (age, gender, ethnicity, stage, comorbidity, body mass index, HPV status, treatment, education, deprivation index, income, marital status, and either smoking or alcohol use) mortality hazard ratios (HR) for the effects of smoking status and alcohol intake at diagnosis. Models were stratified by cancer site, stage and HPV status. The fully‐adjusted HR for current versus never‐smokers was 1.7 overall (95% confidence interval [CI] 1.1, 2.6). In stratified analyses, associations of smoking with mortality were observed for oropharyngeal and laryngeal cancers (fully adjusted HRs for current smokers: 1.8 (95% CI=0.9, 3.40 and 2.3 (95% CI=0.8, 6.4)). We found no evidence that people who drank hazardous to harmful amounts of alcohol at diagnosis had a higher mortality risk compared to non‐drinkers (HR=1.2 (95% CI=0.9, 1.6)). There was no strong evidence that HPV status or tumour stage modified the association of smoking with survival. Smoking status at the time of a head and neck cancer diagnosis influenced all‐cause mortality in models adjusted for important prognostic factors.

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Lifestyle habits as prognostic factors in survival of laryngeal and hypopharyngeal cancer: A multicentric European study

Cited by 80 publications

References 9 publications

Nomograms for preoperative prediction of prognosis in patients with oral cavity squamous cell carcinoma

Nomograms for preoperative prediction of prognosis in patients with oral cavity squamous cell carcinoma

Hypermethylation, risk factors, clinical characteristics, and survival in 235 patients with laryngeal and hypopharyngeal cancers

Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all‐cause mortality: Results from head and neck 5000, a prospective observational cohort of people with head and neck cancer

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