Lifestyle Intervention as the Primary Treatment for Pediatric Nonalcoholic Fatty Liver Disease

Kohut, Taisa; Panganiban, Jennifer

doi:10.1002/cld.1022

Cited by 1 publication

(2 citation statements)

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“…Since NAFLD may progress to cirrhosis and end-stage liver disease [ 26 ], it is fundamental to treat patients as soon as possible. NASPGHAN and ESPGHAN guidelines recommend lifestyle modification (see below), which is considered the only effective treatment for NAFLD in both adults and children [ 107 ].…”

Section: Childhood Obesity and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

“…Lifestyle intervention is considered the first line, as it has no side effects and confers multiple cardiometabolic benefits [ 6 , 107 , 140 ]. Diet- and exercise-intervention-based reduction of body weight has been shown to be effective in reducing hepatic fat deposition in children and adolescents with obesity and NAFLD [ 141 ].…”

Section: The Effects Of Physical Exercise On Nafldmentioning

confidence: 99%

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Benefits of Physical Exercise as Approach to Prevention and Reversion of Non-Alcoholic Fatty Liver Disease in Children and Adolescents with Obesity

et al. 2022

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Non-alcoholic fatty liver disease (NAFLD) is an important health concern during childhood; indeed, it is the most frequent cause of chronic liver diseases in obese children. No valid pharmacological therapies for children affected by this condition are available, and the recommended treatment is lifestyle modification, usually including nutrition and exercise interventions. In this narrative review, we summarized up-to-date information on the benefits of physical exercise on NAFLD in children and adolescents with obesity. The role of exercise as non-pharmacological treatment was emphasized in order to provide recent advances on this topic for clinicians not deeply involved in the field. Several studies on obese children and adults confirm the positive role of physical activity (PA) in the treatment of NAFLD, but to date, there are no pediatric randomized clinical trials on exercise versus usual care. Among the pathogenic mechanisms involved in the PA effects on NAFLD, the main players seem to be insulin resistance and related inflammation, oxidative stress, and gut dysbiosis, but further evaluations are necessary to deeply understand whether these factors are correlated and how they synergistically act. Thus, a deeper research on this theme is needed, and it would be extremely interesting.

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Section: Childhood Obesity and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Section: The Effects Of Physical Exercise On Nafldmentioning

confidence: 99%

Benefits of Physical Exercise as Approach to Prevention and Reversion of Non-Alcoholic Fatty Liver Disease in Children and Adolescents with Obesity

et al. 2022

View full text Add to dashboard Cite

show abstract

Lifestyle Intervention as the Primary Treatment for Pediatric Nonalcoholic Fatty Liver Disease

Abstract: http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/17-3-reading-kohut a video presentation of this article

Cited by 1 publication

References 29 publications

Benefits of Physical Exercise as Approach to Prevention and Reversion of Non-Alcoholic Fatty Liver Disease in Children and Adolescents with Obesity

Benefits of Physical Exercise as Approach to Prevention and Reversion of Non-Alcoholic Fatty Liver Disease in Children and Adolescents with Obesity

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