Lifestyle Intervention for Breast Cancer Women

Hwang, Eun Suk; Nho, Ju-Hee

doi:10.15280/jlm.2019.9.1.12

Cited by 17 publications

(16 citation statements)

References 27 publications

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“…Since the leading risk factor for developing breast cancer stems from prolonged exposure to endogenous hormones, it is not easily modifiable. 51 Primary prevention of breast cancer is achieved by partaking in physical activity, maintaining a healthy weight, following a healthy diet, minimizing alcohol consumption, breastfeeding children, and minimizing the use of oral contraceptive pills and hormone replacement therapy. 51 Testing for BRCA1 and BRCA2 mutations is recommended in women with affected family members.…”

Section: Preventionmentioning

confidence: 99%

“…51 Primary prevention of breast cancer is achieved by partaking in physical activity, maintaining a healthy weight, following a healthy diet, minimizing alcohol consumption, breastfeeding children, and minimizing the use of oral contraceptive pills and hormone replacement therapy. 51 Testing for BRCA1 and BRCA2 mutations is recommended in women with affected family members. 52 A bilateral mastectomy may be performed as prophylaxis for women who test positive for the mutations which are associated with increased risk of breast cancer.…”

Section: Preventionmentioning

confidence: 99%

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Breast Cancer and Lymphedema: A Narrative Review

Michaelides

Constantinou

2019

Int J Med Students

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Breast cancer is the second most common cancer diagnosed worldwide, and the leading cause of cancer death in women. The understanding of disease presentation by patients and health care providers is crucial for a correct diagnosis and management. Preventive measures emphasize risk-reducing behaviors such as a healthy diet, reduced alcohol consumption, increased physical activity, and breastfeeding children. Screening techniques such as mammography, ultrasound, and MRI aid in early detection. Following the screening, a breast biopsy is performed, and a histopathological assessment is carried out to confirm a breast cancer diagnosis. In addition to surgery, radiotherapy, and lifestyle modifications, treatment regimens include a range of medications such as anti-hormonal drugs and chemotherapy. Lymphedema is a severe and major long-term consequence of breast cancer treatment. The major contributors to the diminished lymph drainage are a lumpectomy/mastectomy procedure that involves the surgical removal of lymph nodes, and radiotherapy. The fluid accumulation of lymphedema poses physical limitations to the patient and impacts the overall quality of life. A sentinel lymph node biopsy is an essential method of identifying the first draining lymph nodes affected by metastasis. This procedure allows surgeons to later remove only affected lymph nodes, sparing those that are unaffected and hence reduce the risk and magnitude of lymphedema development. Patients who receive education about lymphedema demonstrate higher compliance with treatment and self-care management practices. The purpose of this review is to provide information about breast cancer, the development of lymphedema, and how to recognize and manage both.

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Section: Preventionmentioning

confidence: 99%

Section: Preventionmentioning

confidence: 99%

Breast Cancer and Lymphedema: A Narrative Review

Michaelides

Constantinou

2019

Int J Med Students

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“…The incidence of breast cancer is increasing rapidly [1]. Of all cancers in women, breast cancer has the highest incidence rate and highest mortality rate [2].…”

Section: Introductionmentioning

confidence: 99%

“…In the current study, we found in a screening test that the MeOH extract of L. cuneata exerted inhibitory effect on metabolic activity in MCF-7 human breast cancer cells, which led us to perform further phytochemical analysis and identify the bioactive compound(s) responsible for these effects. Bioassay-guided fractionation and chemical investigation of the MeOH extract led to the isolation of nine compounds (four lignan glycosides (1)(2)(3)(4), three flavonoid glycosides (5)(6)(7), and two phenolic compounds (8 and 9)). The structures of the isolated compounds were identified by LC-MS analysis and their spectroscopic data and physical data were compared with previously reported values.…”

Section: Introductionmentioning

confidence: 99%

Aviculin Isolated from Lespedeza cuneata Induce Apoptosis in Breast Cancer Cells through Mitochondria-Mediated Caspase Activation Pathway

Lee

et al. 2020

Molecules

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The global incidence of breast cancer has increased. However, there are many impediments to the development of safe and effective anticancer drugs. The aim of the present study was to evaluate the effect of aviculin isolated from Lespedeza cuneata (Dum. Cours.) G. Don. (Fabaceae) on MCF-7 human breast cancer cells and determine the underlying mechanism. Using the bioassay-guided isolation by water soluble tetrazolium salt (WST-1)-based Ez-Cytox assay, nine compounds (four lignan glycosides (1–4), three flavonoid glycosides (5–7), and two phenolic compounds (8 and 9)) were isolated from the ethyl acetate (EA) fraction of the L. cuneata methanolic extract. Of these, aviculin (2), a lignan glycoside, was the only compound that reduced metabolic activity on MCF-7 cells below 50% (IC50: 75.47 ± 2.23 μM). The underlying mechanism was analyzed using the annexin V Alexa Fluor 488 binding assay and Western blotting. Aviculin (2) was found to induce apoptotic cell death through the intrinsic apoptosis pathway, as indicated by the increased expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin (2)-induced apoptotic cell death was accompanied by an increase in the Bax/Bcl-2 ratio. These findings demonstrated that aviculin (2) could induce breast cancer cell apoptosis through the intrinsic apoptosis pathway, and it can therefore be considered an excellent candidate for herbal treatment of breast cancer.

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“…Breast cancer is 1 of the most common cancers diagnosed in females around the world. [1–3] In addition, it is a heterogeneous disease with a variety of subtypes between and within tumors. [4–6] The 3 major subtypes of comprehensive gene expression comprise of luminal, human epidermal growth factor receptor 2 (HER2)-positive, and basal-like cancers.…”

Section: Introductionmentioning

confidence: 99%

Clinical efficacy of combination of pertuzumab, trastuzumab, and docetaxel for treatment of patients with HER2-positive breast cancer

Liu¹,

et al. 2019

Medicine

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Background:This study will systematically investigate the efficacy and safety of the combination of pertuzumab, trastuzumab, and docetaxel (PTD) for treatment of patients with HER2-positive breast cancer (HER2-PBC).Methods:A comprehensive literature search for this study will consist of 2 parts: electronic database records and gray literature. The electronic database literatures are searched from PubMed, EMBASE, Cochrane Library, Web of Science, Google Scholar, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. All databases will be searched from inception up to the present. In addition, gray literatures, such as dissertations, ongoing trials, and so on, will also be searched. Two authors will independently read the records, extract data collection, and evaluate the risk of bias. RevMan V.5.3 software will be applied for statistical analysis.Results:This study will summarize up-to-date evidence of PTD for patients with HER2-PBC via overall survival, complete response, cancer-specific survival, recurrence-free survival, disease-free survival, quality of life, and toxicities.Conclusion:This study will provide efficacy and safety of PTD for HER2-PBC.

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Lifestyle Intervention for Breast Cancer Women

Cited by 17 publications

References 27 publications

Breast Cancer and Lymphedema: A Narrative Review

Breast Cancer and Lymphedema: A Narrative Review

Aviculin Isolated from Lespedeza cuneata Induce Apoptosis in Breast Cancer Cells through Mitochondria-Mediated Caspase Activation Pathway

Clinical efficacy of combination of pertuzumab, trastuzumab, and docetaxel for treatment of patients with HER2-positive breast cancer

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