Lifestyle interventions and quality of life for women with polycystic ovary syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. PCOS has a significant negative impact on the health-related quality of life (HRQoL) and psychological function of women, of which there are reports of high levels of depression in women with PCOS compared to those without PCOS. However, the evidence surrounding the effects of exercise and/or dietary intervention participation on the HRQoL of women with PCOS is limited. Therefore, our objective is to examine the effects of lifestyle interventions (definition include exercise-only, diet-only, exercise + diet and behavioral or combined) on health-related quality of life or general quality of life in women with PCOS.Methods: We will conduct an update of systematic review and we will follow the recommendations and guidelines of the Cochrane handbook for systematic reviews and Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol (PRISMA-P). We will search the studies in the following databases: MEDLINE. PubMed, PsychINFO, Embase, SportDiscus, Web of Science, Cochrane Database (via Cochrane library), Cochrane Controlled Register of Trials (CENTRAL), and Google Scholar (advance). Manual search of the reference list of identified works, without language and year restrictions. The process of study selection and data extraction will be performed independently by 2 reviewers, with a third reviewer being responsible for the final decision in case of disagreement between the first two. We will use Egger funnel chart to evaluate possible publication biases, in addition, when possible we will perform a subgroup/meta-regression analysis. The strength of the evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).

Controle Da Síndrome Dos Ovários Policísticos Por Meio Da Prática De Exercícios Físicos / Control of Polycystic Ovary Syndrome Through Physical Exercise

“…In this context, aerobic exercise interventions associated with resistance exercises, with a frequency of three times a week for at least thirty minutes, may have a greater emphasis on the quality of life of women with PCOS, since during physical exercise there is a series biochemical adaptations that trigger physiological stimuli that increase the consumption of oxygen, the oxidation of free fatty acids and the metabolism is increased to be able to supply the necessary energy and thus reducing the deposit of body fat 2,3 . Thus, the practice of physical exercises has shown a relationship with the improvement of several factors in the health of women with PCOS such as the increase in ovulation rate, menstrual regularity, cardiorespiratory fitness, reduction of mental disorders, in addition to decreasing waist circumference and body fat 2,4 . Thus, weight loss can improve reproductive function, ovulation and improve metabolism, since insulin resistance decreases 4 .…”

“…Thus, the practice of physical exercises has shown a relationship with the improvement of several factors in the health of women with PCOS such as the increase in ovulation rate, menstrual regularity, cardiorespiratory fitness, reduction of mental disorders, in addition to decreasing waist circumference and body fat 2,4 . Thus, weight loss can improve reproductive function, ovulation and improve metabolism, since insulin resistance decreases 4 . Therefore, in view of the scientific findings identified in this study, the importance of physical exercise as a therapeutic conduct for the control of PCOS symptoms is evidenced, being a great alternative in the management of non-pharmacological treatment and contributing to the increase in the quality of life of women.…”

“…. Dessa forma, a prática de exercícios físicos tem demonstrado uma relação com a melhora de vários fatores na saúde das mulheres com SOP como o aumento da taxa de ovulação, regularidade menstrual, aptidão cardiorrespiratória, redução dos transtornos mentais, além de diminuir a circunferência da cintura e a gordura corporal 2,4 . Com isso, a perda de peso pode melhorar a função reprodutiva, a ovulação e melhorar o metabolismo, uma vez que a resistência insulínica diminui 4 .…”

“…Dessa forma, a prática de exercícios físicos tem demonstrado uma relação com a melhora de vários fatores na saúde das mulheres com SOP como o aumento da taxa de ovulação, regularidade menstrual, aptidão cardiorrespiratória, redução dos transtornos mentais, além de diminuir a circunferência da cintura e a gordura corporal 2,4 . Com isso, a perda de peso pode melhorar a função reprodutiva, a ovulação e melhorar o metabolismo, uma vez que a resistência insulínica diminui 4 . Portanto, face aos achados científicos identificados neste estudo, evidencia-se a importância do exercício físico como uma conduta terapêutica para o controle dos sintomas da SOP, sendo uma ótima alternativa no manejo do tratamento não farmacológico e contribuir para o aumento da qualidade de vida das mulheres com SOP.…”

GnRH Antagonist Versus Modified Prolonged GnRH Agonist Protocol in Polycystic Ovary Syndrome (PCOS): Analysis Using Propensity Score Matching

“…The primary pathophysiology of PCOS is insulin resistance, rebound hyperinsulinemia and hyperandrogenemia. These actions result in several clinical features such as persistent anovulation, polycystic ovarian changes, hirsutism, acne and obesity [2].…”