Objectives
Current healthcare systems do not effectively promote weight reduction in obese patients with gastroesophageal reflux disease (GERD). The Reflux Improvement Monitoring (TRIM) program provides personalized, multidisciplinary, health education and monitoring over 6 months. In this study we aimed to (1) measure the effectiveness of TRIM on GERD symptoms, quality of life, and weight, and (2) examine patient health beliefs related to TRIM.
Methods
This prospective mixed methods feasibility study was performed at a single center between 9/2015–2/2017, and included adult patients with GERD and a body mass index ≥30kg/m2. Quantitative analysis consisted of a pre- to post-intervention analysis of TRIM participants (+TRIM Cohort) and a multivariable longitudinal mixed model analysis of +TRIM versus patients who declined TRIM (-TRIM Cohort). Primary outcomes were change in patient-reported GERD symptom severity (GerdQ) and quality of life (GerdQ-DI), and change in percent excess body weight (%EBW). Qualitative analysis was based on two focus groups of TRIM participants.
Results
Among the +TRIM cohort (n=52), mean baseline GerdQ scores (8.7±2.9) decreased at 3 months (7.5±2.2; p < 0.01) and 6 months (7.4±1.9; p = 0.02). Mean GerdQ-DI scores decreased, but did not reach statistical significance. Compared to the -TRIM cohort (n=89), reduction in %EBW was significantly greater at 3, 6, and 12-months among the +TRIM cohort (n=52). In qualitative analysis, patients unanimously appreciated the multidisciplinary approach and utilized weight loss effectively to improve GERD symptoms.
Conclusions
In this mixed methods feasibility study, participation in TRIM was associated with symptom improvement, weight reduction and patient engagement.