LIFEStyle, Prevention and Risk of Acute PaNcreatitis (LIFESPAN): protocol of a multicentre and multinational observational case–control study

Abstract

IntroductionAcute pancreatitis (AP) is a life-threatening inflammatory disease of the exocrine pancreas which needs acute hospitalisation. Despite its importance, we have significant lack of knowledge whether the lifestyle factors elevate or decrease the risk of AP or influence the disease outcome. So far, no synthetising study has been carried out examining associations between socioeconomic factors, dietary habits, physical activity, chronic stress, sleep quality and AP. Accordingly, LIFESPAN identifies risk factors of acute pancreatitis and helps to prepare preventive recommendations for lifestyle elements.Methods and analysisLIFESPAN is an observational, multicentre international case–control study. Participating subjects will create case and control groups. The study protocol was designed according to the SPIRIT guideline. Patients in the case group (n=1700) have suffered from AP (alcohol-induced, n=500; biliary, n=500; hypertriglyceridemiainduced, n=200; other, n=500); the control group subjects have no AP in their medical history. Our study will have three major control groups (n=2200): hospital-based (n=500), population-based (n=500) and aetiology-based (alcohol, n=500; biliary, n=500 and hypertriglyceridemia, n=200). All of them will be matched to the case group individually by gender, age and location of residence. Aggregately, 3900 subjects will be enrolled into the study. The study participants will complete a complex questionnaire with the help of a clinical research administrator/study nurse. Analysis methods include analysis of the continuous and categorical values.Ethics and disseminationThe study has obtained the relevant ethical approval (54175-2/2018/EKU) and also internationally registered (ISRCTN25940508). After obtaining the final conclusions, we will publish the data to the medical community and will also disseminate our results via open access.Trial registration numberISRCTN25940508; Pre-results.

Prophylactic low-molecular-weight heparin administration protected against severe acute pancreatitis partially by VEGF/Flt-1 signaling in a rat model

“…[29][30][31] .A recent study was also carried out to identify risk factors of acute pancreatitis and help to prepare preventive recommendations for lifestyle elements. 32 Emerging evidence suggests that VEGF plays an important role in the host inflammatory response in many diseases. 33,34 Several studies have also confirmed that VEGF plays an effect in inflammatory response mainly by binding to Flt-1.…”

Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (REAPPEAR): protocol of a randomised controlled trial and a cohort study

“… 66 67 Socioeconomic status will be assessed at baseline and at 12 and 24 months with the questionnaire used in the LIFESPAN study. 68 …”

“…66 67 Socioeconomic status will be assessed at baseline and at 12 and 24 months with the questionnaire used in the LIFESPAN study. 68 The aetiology of each recurrent episode will be determined following current international guidelines, but all episodes will be included in the primary endpoint. 4 34 Blood pressure, heart rate and body weight will be measured by an independent nurse blind to the allocation at every visit.…”

Assessment of Acute Pancreatitis Severity and Prognosis with CT-Measured Body Composition

“…It has been reported that intake of vegetables, fish, fiber, and milk may reduce the risk of AP. [38][39][40] Results of a prospective cohort study of 0.5 million people showed that there was an inverse association between physical activity and risk of AP. 41 It has also been reported that combined aerobic exercise and resistance exercise may reduce the occurrence of sarcopenia obesity and improve muscle function.…”