Lifestyles and mental health status are associated with natural killer cell and lymphokine-activated killer cell activities

Morimoto, Kanehisa; Takeshita, Tatsuya; Inoue-Sakurai, Chimako; Maruyama, Soichiro

doi:10.1016/s0048-9697(00)00782-8

Cited by 60 publications

(62 citation statements)

References 36 publications

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“…This implies that the improvement in exercise enhanced not only SOC, but also NKCA. There is little evidence showing that exercise enhances immune functions by moderating stress 27,28) . The multiple regression analysis demonstrated that the improvement in exercise after health education positively contributed to changes in SOC and NKCA in never smokers, independently of psychological factors.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of a Sense of Coherence and Natural Killer Cell Activity which Occurred in Subjects who Improved their Exercise Habits through Health Education in the Workplace

Nakamura

Matsuzaki

Sasahara

et al. 2003

Journal of Occupational Health

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independently of other psychological factors. These results suggest that subjects with improvement in exercise enhance NKCA through increased SOC in never smokers. (J Occup Health 2003; 45: 278-285) Key words: Exercise, Health education, Natural killer cell activity, Sense of coherence, Stress, Work SOC, a candidate for a mediating stress factor, is studied in the framework of Antonovsky's salutogenesis paradigm, which emphasizes the origin of health [1][2][3][4] . Life events stressors, depression and anxiety as well as work-setting characteristics, particularly work stressors, influence levels of SOC 2,[5][6][7] . Emotional stress was reported to be associated with a decrease in cellular immune function including natural killer cell activity (NKCA) in humans 8,9) . SOC is involved in NKCA in relation to work stress 10) and life stress 11) . We have suggested that SOC may be an important psychological modifier in determining the relationship between NKCA and smoking 10) . Besides smoking cessation, a worksite exercise program is one of the principal policies to promote health in Japan and other countries [12][13][14] . Exercise enhances NKCA directly or through changes in lifestyles such as cessation of smoking, reduction of weight or possibly psychological outcomes 15,16) , although little is known about the psychological significance of exercise on SOC and NKCA. In the present study, therefore, we examined SOC and NKCA in office workers who improved their exercise habits after health education to clarify the effects of exercise on SOC and NKCA.Received Sep 11, 2002; Accepted June 19, 2003 Abstract: Enhancement of a Sense of Coherence and Natural Killer Cell Activity which Occurred in Subjects who Improved their Exercise Habits through Health Education in the Workplace: H i r o y u k i N A K A M U R A, e t a l . D e p a r t m e n t o f Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University-We have previously demonstrated that a sense of coherence (SOC), a candidate for a mediating stress factor, is involved in natural killer cell activity (NKCA) reduced in smokers, whereas the relationship among exercise, NKCA and SOC is unclear. To clarify the effects of exercise on SOC and NKCA, we examined the changes in SOC and NKCA before and after health education to encourage exercise. Of one-hundred and one male office workers who received the health education for one year, 27 improved, 65 were unchanged and 9 had deteriorated exercise habits. The repeated measures analysis of variance showed that SOC in workers with improvement in the exercise habit were increased more significantly by the health education than those in workers without improvement (p<0.05). Although the change in NKCA produced by health education was recognized to be significantly different in those who had never smoked from that in current smokers (p<0.05), multiple regression analysis demonstrated that improvement in health practice significantly contributed to increases in both SOC (p<0.01) and NKCA (p...

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Section: Discussionmentioning

confidence: 99%

Enhancement of a Sense of Coherence and Natural Killer Cell Activity which Occurred in Subjects who Improved their Exercise Habits through Health Education in the Workplace

Nakamura

Matsuzaki

Sasahara

et al. 2003

Journal of Occupational Health

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“…Lifestyle was assessed using the Healthy Living Index (HLI), based on the parameters adopted by Morimoto et al, 21 which are: don't smoke; don't consume alcoholic beverages on a daily basis; eat breakfast every day; sleep between seven and eight hours per night; work less than ten hours per day; exercise at least once a week; maintain a nutritionally-balanced diet; and suffer a moderate level of mental stress (selfreported by the interviewee). The following extra variables were also considered: the use of oral antiseptics; the absence of chronic illnesses and the non-exposure to genotoxic agents and toxic products.…”

Section: Healthy Living Indexmentioning

confidence: 99%

Effects of age on the frequency of micronuclei and degenerative nuclear abnormalities

Ferraz

Neto

Cerqueira

et al. 2016

Rev. bras. geriatr. gerontol.

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The effects of aging, gender and lifestyle factors on inducing chromosomal damage (micronuclei) and nuclear degenerative changes were assessed using the micronucleus test on exfoliated cells of the oral mucosa. The sample included 80 healthy subjects divided into four groups according to age and gender: men and women aged 19-29 years (M19, W19) and men and women aged over sixty years (M60, W60). An interview questionnaire was used to characterize the sample and to determine an index reflecting lifestyle (HLI). The frequency of micronuclei and nuclear degenerative changes was significantly higher among the elderly ( p<0.001) and did not differ by gender among young people ( p>0.05). The occurrence of micronuclei was similar among elderly men and women ( p>0.10), but karyorrhexis and karyolysis were more frequent among men ( p<0.005 and p<0.025, respectively), who also had a lower HLI than the other groups ( p<0.0004). The results of the study indicate that age is the main factor associated with the induction of genetic material damage.

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“…The phar macokinetics of PEGylated IFN are different from those of standard IFN [53] and the time of depression occurrence also differs between PEGylated and standard IFN [54] ; therefore, it will be important to determine if the mechanisms described by Cai et al [52] on GR and 5-HTR1A receptors also apply to PEGylated IFN. In addition, anxiety and depression impair the level and activity of B cells, T cells, and NK cells [55] . No differences in depression rates were observed by Neri et al [56] comparing PEGylated-α 2a and PEGylated-α 2b, and this finding has recently been confirmed in the large randomized comparison trial 'IDEAL' [57] .…”

Section: Depressionmentioning

confidence: 99%

Hepatitis C comorbidities affecting the course and response to therapy

El-Zayadi¹

2009

WJG

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Several studies have demonstrated that the outcome of chronic hepatitis C (CHC) infection is profoundly influenced by a variety of comorbidities. Many of these comorbidities have a significant influence on the response to antiviral therapy. These comorbidities negatively affect the course and outcome of liver disease, often reducing the chance of achieving a sustained virological response with PEGylated interferon and ribavirin treatments. Comorbidities affecting response to antiviral therapy reduce compliance and adherence to inadequate doses of therapy. The most important comorbidities affecting the course of CHC include hepatitis B virus coinfection, metabolic syndrome, and intestinal bacterial overgrowth. Comorbidities affecting the course and response to therapy include schistosomiasis, iron overload, alcohol abuse, and excessive smoking. Comorbidities affecting response to antiviral therapy include depression, anemia, cardiovascular disease, and renal failure.

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Lifestyles and mental health status are associated with natural killer cell and lymphokine-activated killer cell activities

Cited by 60 publications

References 36 publications

Enhancement of a Sense of Coherence and Natural Killer Cell Activity which Occurred in Subjects who Improved their Exercise Habits through Health Education in the Workplace

Enhancement of a Sense of Coherence and Natural Killer Cell Activity which Occurred in Subjects who Improved their Exercise Habits through Health Education in the Workplace

Effects of age on the frequency of micronuclei and degenerative nuclear abnormalities

Hepatitis C comorbidities affecting the course and response to therapy

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