Lifestyles Associated With Human Semen Quality

Yang, Huan; Chen, Qing; Zhou, Nina; Sun, Lei; Bao, Huaqiong; Tan, Lu; Chen, Hongqiang; Zhang, Guowei; Liu, Xi; Huang, Linping; Li, Lianbing; Ma, Mingfu; Yang, Hsiao-Ching; Wang, Xiaogang; Zou, Peng; Peng, Kaige; Liu, Kaijun; Liu, Taixiu; Cui, Zhihong; Liu, Jinyi; Ao, Lin; Zhou, Ziyuan; Cao, Jia

doi:10.1097/md.0000000000001166

Cited by 60 publications

(52 citation statements)

References 61 publications

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“…A total of 666 eligible subjects attended the followed-up procedure in 2014, among which 10 failed to provide semen sample. More detailed information about the study design, screening process and lifestyles questionnaire can be found in the previous report [20]. …”

Section: Methodsmentioning

confidence: 99%

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Mitochondrial Biomarkers Reflect Semen Quality: Results from the MARCHS Study in Chongqing, China

et al. 2016

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Unexplained infertility requires that more sensitive and mechanism-based biomarkers should be developed and used independently of or in addition to conventional semen parameters for an infertility diagnosis. In the present study, semen samples were collected from young men participating in the Male Reproductive Health in Chongqing College students (MARCHS) cohort study in the follow-up stage in 2014. Conventional semen parameters were measured in all 656 participants, whereas sperm mitochondrial membrane potential (MMP), mitochondrial DNA copy number (mtDNAcn), mtDNA integrity and apoptotic parameters were measured among 627, 386, 362, and 628 participants, respectively. We found that sperm MMP was significantly positively correlated with all of conventional semen parameters including semen volume (r = 0.090, p = 0.025), sperm concentration (r = 0.301, p<0.01), total sperm count (r = 0.324, p<0.01), and progressive motility (r = 0.399, p<0.01); sperm MMP was also negatively correlated with Annexin V+ sperm (r = -0.553, p<0.01); mtDNAcn was significantly negatively correlated with sperm concentration (r = -0.214, p<0.01), total sperm count (r = -0.232, p<0.01), and progressive motility (r = -0.164, p = 0.01); mtDNA integrity was also significantly positively correlated with sperm concentration (r = 0.195, p<0.01), total sperm count (r = 0.185, p<0.01), and progressive motility (r = 0.106, p = 0.043). After adjusting for potential confounders, these relationships remained significant. Furthermore, we explored the potential effects of lifestyles on such mitochondrial biomarkers and found that the current drinkers displayed a higher level of sperm MMP; additionally, mt DNAcn was increased with age. The results indicated that certain mitochondrial biomarkers could serve as predictors of semen quality in a general population, and the study provides a baseline for the effects of population characteristics and lifestyles on such mitochondrial markers.

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Section: Methodsmentioning

confidence: 99%

“…As described previously [20], the semen samples were collected in a special semen container via masturbation in a private room. Upon receipt, the semen appearance was recorded, and semen volume was measured by weighing, assuming 1 g of weight was equal to 1 ml of volume.…”

Section: Methodsmentioning

confidence: 99%

Mitochondrial Biomarkers Reflect Semen Quality: Results from the MARCHS Study in Chongqing, China

et al. 2016

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“…At first glance, we supposed this finding could be due to alcohol intake. For example, participants in the Chinese study drank less frequently and had higher sperm motility [25]. Nevertheless, the findings of a cross-sectional study of 8344 healthy men (in Europe and the USA) demonstrated that alcohol intake was not associated with motility no any other semen variable [26].…”

Section: Prace Oryginalnementioning

confidence: 90%

“…However, the median percentage of morphologically normal sperm was lower (8% vs. 14%). Although the prevalence of cigarette smoking was similar between our cohorts, the participants in the Chinese study drank alcohol less frequently (51% vs. 91%) [25].…”

Section: Prace Oryginalnementioning

confidence: 99%

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The quality of semen among a sample of young, healthy men from Lower Silesia (AndroLS)

Mędraś¹,

Lwow

Jóźków

et al. 2015

Endokrynologia Polska

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Introduction: Contrary to other parts of the continent, little information is available regarding semen quality among subjects from central and eastern Europe. Material and methods:We evaluated semen profiles among a sample of men from an industrialised region of Poland. We directly invited 5000 healthy inhabitants of the region (aged 18-35 years; with unchecked fecundity) to participate in the study. Among the 500 who were eligible and willing to participate, we acquired detailed information and semen and blood samples from 177 subjects. Results: Semen volume, sperm concentration, and total sperm count were, respectively, (mean ± SD): 3.1 ± 1.5 ml, 60 ± 44 x 10

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Phosphodiesterase Inhibitors (PDE Inhibitors) and Male Reproduction

Drobnis

Nangia

2017

Advances in Experimental Medicine and Biology

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The nonspecific PDE inhibitors, particularly the methylxanthines: caffeine, pentoxifylline (PTX), and theophylline, are known to stimulate sperm motility in vitro and have been used to treat sperm prior to insemination. The in vivo effects are less dramatic. A beneficial effect of caffeine, which is a constituent of some medications, remains controversial. Very high doses of caffeine do have negative effects on fertility endpoints in men and experimental species. The specific PDE5 inhibitors, particularly sildenafil and tadalafil, are prescribed for erectile dysfunction, as well as pulmonary hypertension, lower urinary tract symptoms, and premature ejaculation. PDE5 is expressed throughout the contractile tissues of the male reproductive tract, generally increasing contractility. Some PDE5 inhibitors tend to increase circulating testosterone levels somewhat. For short-term exposure consistent with use prior to intercourse, there appears to be minimal effects on semen quality. Several large, randomized controlled trials (RCTs) in healthy men have not found adverse effects of long-term use of these drugs on semen quality. RCTs in infertile men have demonstrated a modest increase in semen quality. Animal studies at human equivalent doses (HED) have produced similar results in young males, but a study in aging male rats found progressive decreases in epididymal sperm quality accompanied by consistent degeneration of the seminal tubules suggesting that studies in older men might be warranted. A concerning study in mice found lower fertilization rates in males treated with HED of sildenafil and mated the next day to untreated females than for control males. Fertility studies in humans are needed.

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Lifestyles Associated With Human Semen Quality

Abstract: Supplemental Digital Content is available in the text

Cited by 60 publications

References 61 publications

Mitochondrial Biomarkers Reflect Semen Quality: Results from the MARCHS Study in Chongqing, China

Mitochondrial Biomarkers Reflect Semen Quality: Results from the MARCHS Study in Chongqing, China

The quality of semen among a sample of young, healthy men from Lower Silesia (AndroLS)

Phosphodiesterase Inhibitors (PDE Inhibitors) and Male Reproduction

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