Lifetime-based nanothermometry <i>in vivo</i> with ultra-long-lived luminescence

Su, Xianlong; Wen, Yangping; Yuan, Wei; Xu, Ming; Liu, Qian; Huang, Chunhui; Li, Fuyou

doi:10.1039/d0cc04459h

Cited by 39 publications

(34 citation statements)

References 37 publications

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“…SOF served as an energy bridge to connect the chemical-energy (stored in reactive 1 O 2 molecules) and photo-energy (stored in excited states) through photochemical reactions. In view of the fleeting lifetimes of both 1 O 2 and excited states in solution (<1 ms), SOF also shortly stored the energy for later use (as an energy cache unit), which was a rate-determining step to prolong luminescence durations into the afterglow level [26]. In terms of the afterglow, similar results with that of steady-state studies were obtained.…”

Section: Design Of Photochemical Afterglow Materials In the Homogeneous Liquid Statesupporting

confidence: 67%

“…Solvents were purchased from Sinopharm Chemical Reagent Co., Ltd. (China). The N,N-dibutyl-4-(2-(4-fluorophenyl)-5,6-dihydro-1,4-oxathiin-3-yl)aniline (SOF) oil and Eu-complexes were prepared by methods described in the literatures [26,27] with some modifications (Figures S1 and S2, Schemes S1 and S2, Supporting Information online). Inorganic afterglow powders with blue, green and red emission were purchased from Xiucai Chemical Co., Ltd. (Foshan, China).…”

Section: Materials and Instrumentsmentioning

confidence: 99%

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Lanthanide-containing persistent luminescence materials with superbright red afterglow and excellent solution processability

Liu

et al. 2021

Sci. China Chem.

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Lanthanide-containing persistent luminescence materials are promising candidates for a wide range of applications by virtue of splendid superiorities in afterglow performance. However, it is a crucial challenge to achieve high-quality afterglow materials at the attractive nanoscale, with uniform size, controllable morphology, and satisfying brightness. Herein, a bottom-up approach was developed to construct the high-quality afterglow nanoparticles, incorporating luminescent lanthanide complex and organic molecular ingredients under mild conditions. These nanoparticles exhibited intrinsic lanthanide luminescence with superbright red afterglow (>10 cd m −2 ) in a homogeneous solution. The afterglow solution with excellent processability can serve as ideal building blocks for the on-demand fabrication of functional nanomaterials. Water-dispersible afterglow nanoparticles with stateof-the-art high brightness were uniformly constructed to perform whole-blood lateral flow assay of procalcitonin with a nakedeye detection limit of 0.5 ng mL −1 , promoting the point-of-care testing development.

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Section: Design Of Photochemical Afterglow Materials In the Homogeneous Liquid Statesupporting

confidence: 67%

Section: Materials and Instrumentsmentioning

confidence: 99%

Lanthanide-containing persistent luminescence materials with superbright red afterglow and excellent solution processability

Liu

et al. 2021

Sci. China Chem.

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“…It was demonstrated to be a typical deep blue emission, which might be attributed to the fluorescence emission of the triphenylamine group in CUEM. The afterglow lifetime was measured by a time‐gated detection technique [16d] . As shown in Figure 2c, the afterglow luminescence exhibited single‐exponential decay, and the afterglow lifetime was 2.4 s at 25 °C.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Blue Afterglow through Molecular Fusion for Bio‐applications

Kong

Sun

et al. 2022

Angewandte Chemie

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Afterglow materials have drawn considerable attention due to their attractive luminescent properties. However, their low‐efficiency luminescence in aqueous environment limits their applications in life sciences. Here, we developed a molecular fusion strategy to improve the afterglow efficiency of photochemical afterglow materials. By fusing a cache unit with an emitter, we obtained a blue afterglow system with a quantum yield up to 2.59 %. This is 162 times higher than that achieved with the traditional physical mixing system and more than an order of magnitude larger than that of the covalent coupling system. High‐efficiency afterglow nanoparticles were obtained and utilized for bio‐imaging with a high signal‐to‐noise ratio (SNR) of 131, and for the lateral flow immunoassay (LFIA) of β‐hCG with a low limit of detection (LOD) of 0.34 mIU mL−1. This paves a new way for the construction of high‐efficiency afterglow materials and expands the number of luminescence reporter candidates for disease diagnosis and bio‐imaging.

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“…The design of molecular afterglow reporter FDAG-1 is based on the incorporation of an electron acceptor moiety at the ortho position of the phenol in Schaap’s chemiluminescence dioxetane. − Different from the discrete photochemical cache unit and emitter, − FDAG-1 can be used as a dual-functional molecule including photochemical cache and bright emission functions. , Moreover, to shift the emission wavelength to the red light region, a quinolinecarboxylic acid moiety as an electron acceptor and the ortho position of the phenol (as an electron donor) are conjugated with a vinyl group. At the same time, to improve water solubility, carboxylic acid is also introduced into this report, as shown in Scheme a.…”

Section: Resultsmentioning

confidence: 99%

Afterglow Amplification for Fast and Sensitive Detection of Porphyria in Whole Blood

Yuan

Guo

et al. 2021

ACS Appl. Mater. Interfaces

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Porphyria is a group of genetic photodermatoses that cause too much porphyrin to accumulate in the blood, skin, and liver, resulting in skin photosensitivity and damage, liver disease, or potential liver failure. Conventional detection methods include high-performance liquid chromatography and fluorescence spectrometry. However, these methods usually require complicated pretreatment and time-consuming processes. Therefore, efficient and fast detection of porphyria is urgently needed. Herein, we develop a molecular afterglow reporter-based sensing scheme for the detection of porphyrins in whole blood. The afterglow reporter can respond to the production of singlet oxygen (1O2) of porphyrins after light excitation, and the detection signals can be amplified through adjusting the amount of singlet oxygen and afterglow reporter molecules. Moreover, without the use of a real-time excitation source, afterglow signals can avoid the scattering and autofluorescence interference in biological samples, thereby reducing background noise. More importantly, we prove the applicability of the afterglow reporter in the quantitative detection of porphyrins in whole blood and demonstrate its great clinical potential.

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Lifetime-based nanothermometry in vivo with ultra-long-lived luminescence

Abstract: We developed a luminescence lifetime-based nanothermometer with a single-exponential luminescence decay in the ~s time scope by introducing photochemical reaction. The luminescence lifetime imaging in vivo can be performed on...

Cited by 39 publications

References 37 publications

Lanthanide-containing persistent luminescence materials with superbright red afterglow and excellent solution processability

Lanthanide-containing persistent luminescence materials with superbright red afterglow and excellent solution processability

Enhanced Blue Afterglow through Molecular Fusion for Bio‐applications

Afterglow Amplification for Fast and Sensitive Detection of Porphyria in Whole Blood

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