Lifetime cost for type 2 diabetes mellitus in Singapore

Ang, Yee Gary; Yap, Chun Wei; You, Alex Xiaobin

doi:10.1111/1753-0407.12604

Cited by 7 publications

(4 citation statements)

References 15 publications

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“… 3 In Singapore, the prevalence of diabetes has increased from 8.2% in 2004 to 11.3% in 2010 and is projected to increase to 15% by 2050. 4 The rate of all diabetes-related major lower extremity amputation (LEA) has increased from 11.0/100 000 population in 2008 to 13.3/100 000 in 2013 and according to the latest Organization for Economic Co-operation and Development (OECD) Report , 5 , 6 major LEA rates in Singapore are 2 to 3 fold higher than that in western countries – the highest in the world. The magnitude of the disease burden from DFU places considerable demands on the local healthcare settings.…”

Section: Introductionmentioning

confidence: 99%

An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox^™) on the Rates of Healing of Chronic DiAbetic Foot Ulcers (OTONAL Trial)

Tang

Mak

Yap

et al. 2021

The International Journal of Lower Extremity Wounds

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Natrox™ topical oxygen therapy (TOT) ( Inotec AMD Ltd, Cambridgeshire, UK) employs a small battery-powered “oxygen generator” to concentrate atmospheric oxygen and feeds pure, moist, oxygen through a fine, soft tube to a dressing-like “oxygen distribution system”, which is placed over the wound and is held in place by a conventional dressing. The aim was to determine the effectiveness of Natrox™ for non-healing diabetic foot ulcers (DFU) over a 3-month period.Longitudinal, single-arm, open prospective registry study using 12 weeks of TOT using a 4 week run-in period. 20 patients recruited to OTONAL had chronic DFU greater than 3 months duration or minor amputation sites with less than 50% healing in 4 weeks.There were 13 (65%) males and the mean age was 65.7 (±11.6) years. The mean glycated haemoglobin (HbA1c) was 6.9 (±1.3) mmol mol−1 and mean wound duration before TOT was 114 (±79.1) days. 18/20 (90.0%) patients had concomitant lower limb revascularization angioplasty for chronic limb threatening ischaemia. The mean size of the foot ulcer at baseline was 11.3 ± 14.8 cm2 and mean transcutaneous oxygen measurement value was 34.1 (±19.6) mm Hg. Wound closure of >75% was observed in 14/20 (70.0%) patients. There was a 91.3% (±14.9%) wound area reduction by 3 months (P = .001) and mean time for 100% closure was 77.6 ± 32.5 days. Mean pain scores reduced from 2.4 (±1.8) at baseline to .5 (±1.0) at 3 months (P = .008). All patients were very satisfied using the ambulatory device. Use of TOT in chronic diabetic foot wounds stimulates a healing state, underpinning the concept that oxygen plays a central role in wound healing. Our results are more compelling if you consider they started with relatively large-sized DFUs and majority of patients were frail with underlying peripheral artery disease. (NCT03863054)

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Section: Introductionmentioning

confidence: 99%

An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox^™) on the Rates of Healing of Chronic DiAbetic Foot Ulcers (OTONAL Trial)

Tang

Mak

Yap

et al. 2021

The International Journal of Lower Extremity Wounds

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“…Type 2 diabetes (T2DM) accounts for 99% of all diagnosed cases of diabetes (5). The lifetime medical expenditure of patients with diabetes was shown to be 5.6 times higher than that of patients with nondiabetes (6). Nationally, healthcare spending for diabetes is estimated to increase from US$787 million in 2010 to US $1,867 million in 2050 (7).…”

Section: Introductionmentioning

confidence: 99%

Healthcare Professionals’ Views of Factors Influencing Diabetes Self-Management and the Utility of a mHealth Application and Its Features to Support Self-Care

Yoon

Kwan

et al. 2022

Front. Endocrinol.

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IntroductionThe perspectives of healthcare professionals (HCPs) are pivotal to co-development of self-management strategies for patients with diabetes. However, literature has been largely limited to perspectives of patients within the context of a Western healthcare setting. This study aims to explore factors influencing diabetes self-management in adult patients with diabetes from the perspectives of HCPs and their views of the value of mHealth application for diabetes self-management.Materials and MethodsWe conducted focus group discussions (FGD) with purposively selected HCPs in Singapore. All FGDs were audio-recorded and transcribed verbatim. Thematic analysis was conducted using NVivo 12.ResultsA total of 56 HCPs participated in the study. Barriers to self-management included limited patient commitment to lifestyle changes, suboptimal adherence to medication and treatment, patient resistance to insulin initiation and insufficient rapport between patients and HCPs. Patients’ perceived susceptibility to complications, social support from family and community, multidisciplinary team care and patient’s understanding of the benefits of self-care were viewed as facilitating self-management. HCPs saw mHealth apps as a vital opportunity to engage patients in the self-management of conditions and empower them to foster behavior changes. Yet, there were concerns regarding patient’s limited digital literacy, lack of integration into routine electronic system and reluctance.DiscussionWe identified a set of factors influencing self-management in adult patients with diabetes and useful app features that can empower patients to manage their conditions. Findings will inform the development of a mHealth application, and its features designed to improve self-care.

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“…Diabetes is expected to impose a massive economic burden on individuals and countries around the world due to the high risk of mortality [4,5]. It has been con rmed that cardiovascular diseases (CVDs) [6], kidney failure [7], and some types of site-speci c cancer [8] are the most common complications of T2DM that often arise together, which could collectively lead to a decline in life expectancy and even death [9].…”

Section: Introductionmentioning

confidence: 99%

The Combined Effects of Animal Products Intake and Physical Activity With Cause-specific and All-cause Mortality Among Patients With Type 2 Diabetes Mellitus in China: A Prospective Cohort Study

Hou

Pei

et al. 2022

Preprint

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BackgroundTo determine the associations of animal products intake and physical activity and their combined effects with cause-specific and all-cause mortality among type 2 diabetes mellitus (T2DM) patients in China.MethodsBaseline data of 7311 type 2 diabetes mellitus (T2DM) patients recruited with a stratified random cluster sampling method were collected from December 2013 to January 2014. Participants were followed up until the date of their death or December 2019 for survivors, whichever came first. Nonlinear trends of cause-specific and all-cause mortality were assessed using restricted cubic splines with three knots placed at centiles 10, 50, and 90 of diet intake. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the combined relationship of physical activity and animal products with cause-specific and all-cause mortality.ResultsDuring a median follow-up of 6.1 years, 692 (9.5%) T2DM patients died. The main cause of death was cardiovascular disease (CVD) (35.8%), followed by cancer (20.6%). After multivariable adjustment, a higher level of physical activity was nonlinearly associated with lower all-cause and CVD mortality in a J-shaped pattern, with the protective effect observed >8 MET-h/d. Higher consumption of red meat, poultry, and aquatic products was associated with a lower risk of all-cause mortality (HR = 0.75, 0.64, 0.75, respectively, all P<0.05). In the highest tertiles of physical activity, a higher intake of red meat, poultry, and aquatic products was associated with a lower risk for all-cause mortality than in the lowest tertiles (red meat, HR = 0.80, 0.62, 0.51, and 0.48; poultry, HR = 0.85, 0.51, 0.48, and 0.45; aquatic products, HR = 0.80, 0.57, 0.55, and 0.40, respectively). Similarly, the protective effect of moderate to high intake of poultry, aquatic products, and eggs on CVD mortality in high physical activity was found. ConclusionsOur study highlights that in T2DM patients, better adherence to moderate to high consumption of animal products, including red meat, poultry, and aquatic products, together with engaging in moderate to high levels of physical activity exerts a beneficial effect in lowering cause-specific and all-cause mortality in China.

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Lifetime cost for type 2 diabetes mellitus in Singapore

Cited by 7 publications

References 15 publications

An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox^™) on the Rates of Healing of Chronic DiAbetic Foot Ulcers (OTONAL Trial)

An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox^™) on the Rates of Healing of Chronic DiAbetic Foot Ulcers (OTONAL Trial)

Healthcare Professionals’ Views of Factors Influencing Diabetes Self-Management and the Utility of a mHealth Application and Its Features to Support Self-Care

The Combined Effects of Animal Products Intake and Physical Activity With Cause-specific and All-cause Mortality Among Patients With Type 2 Diabetes Mellitus in China: A Prospective Cohort Study

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Lifetime cost for type 2 diabetes mellitus in Singapore

Cited by 7 publications

References 15 publications

An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox™) on the Rates of Healing of Chronic DiAbetic Foot Ulcers (OTONAL Trial)

An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox™) on the Rates of Healing of Chronic DiAbetic Foot Ulcers (OTONAL Trial)

Healthcare Professionals’ Views of Factors Influencing Diabetes Self-Management and the Utility of a mHealth Application and Its Features to Support Self-Care

The Combined Effects of Animal Products Intake and Physical Activity With Cause-specific and All-cause Mortality Among Patients With Type 2 Diabetes Mellitus in China: A Prospective Cohort Study

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Product

Resources

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An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox^™) on the Rates of Healing of Chronic DiAbetic Foot Ulcers (OTONAL Trial)

An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox^™) on the Rates of Healing of Chronic DiAbetic Foot Ulcers (OTONAL Trial)