Lifetime evolution of ADHD treatment

Mucci, Federico; Carpita, Barbara; Pagni, G; Vecchia, Alessandra Della; Bjedov, Sarah; Pozza, Andrea; Marazziti, Donatella

doi:10.1007/s00702-021-02336-w

Cited by 4 publications

(3 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Attention deficit hyperactivity disorder (ADHD), a neurodevelopmental mental disorder, is characterized by inattention, hyperactivity, and impulsive behavior (1,2). The ADHD arises in childhood and may persist in adulthood (3,4). The abnormalities in memory processes were also found in patients with ADHD (5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Modulation of Spatial Memory Deficit and Hyperactivity in Dopamine Transporter Knockout Rats via α2A-Adrenoceptors

et al. 2022

View full text Add to dashboard Cite

Attention deficit hyperactivity disorder (ADHD) is manifested by a specific set of behavioral deficits such as hyperactivity, impulsivity, and inattention. The dopamine neurotransmitter system is postulated to be involved in the pathogenesis of ADHD. Guanfacine, a selective α2A-adrenoceptor agonist, is prescribed for ADHD treatment. ADHD also is known to be associated with impairment of multiple aspects of cognition, including spatial memory, however, it remains unclear how modulation of the norepinephrine system can affect these deficits. Hyperdopaminergic dopamine transporter knockout (DAT-KO) rats are a valuable model for investigating ADHD. The DAT-KO rats are hyperactive and deficient in spatial working memory. This work aimed to evaluate the effects of noradrenergic drugs on the fulfillment of spatial cognitive tasks by DAT-KO rats. The rats were tested in the Hebb – Williams maze during training and following noradrenergic drugs administration. The efficiency of spatial orientation was assessed as to how fast the animal finds an optimal way to the goal box. Testing in a new maze configuration allowed us to evaluate the effects of drug administration after the acquisition of the task rules. The behavioral variables such as the distance traveled, the time to reach the goal box, and the time spent in the error zones were analyzed. It has been observed that α2A-adrenoceptor agonist Guanfacine (0.25 mg/kg) had only a minimal inhibitory effect on hyperactivity of DAT-KO rats in the maze but significantly ameliorated their perseverative pattern of activity and reduced the time spent in the error zones. In contrast, α2A-adrenoceptor antagonist Yohimbine, at the dose of 1 mg/kg, increased the distance traveled by DAT-KO rats and elevated the number of perseverative reactions and the time spent in the error zones. Guanfacine caused minimal effects in wild-type rats, while Yohimbine altered several parameters reflecting a detrimental effect on the performance in the maze. These data indicate that modulation of α2A-adrenoceptor activity potently affects both dopamine-dependent hyperactivity and cognitive dysfunctions. Similar mechanisms may be involved in the beneficial effects of Guanfacine on cognitive deficits in ADHD patients. This study further supports the translational potential of DAT-KO rats for testing new pharmacological drugs.

show abstract

Section: Introductionmentioning

confidence: 99%

Modulation of Spatial Memory Deficit and Hyperactivity in Dopamine Transporter Knockout Rats via α2A-Adrenoceptors

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent problems of inattention, hyperactivity, and impulsivity, with a debut in childhood [1]. While some who met diagnostic criteria as children or adolescents no longer meet diagnostic criteria in adulthood [2], it is estimated that about 2.5% of adults have ADHD worldwide [3,4]. People diagnosed with ADHD often display secondary psychiatric problems, with 80% having a concurrent psychiatric diagnosis [5,6].…”

Section: Introductionmentioning

confidence: 99%

Psychoeducation for adult ADHD: a scoping review about characteristics, patient involvement, and content

Pedersen,

Skliarova,

Pedersen

et al. 2024

BMC Psychiatry

View full text Add to dashboard Cite

Background Psychosocial interventions such as psychoeducation are increasingly being used to treat adult ADHD, both as an alternative and as a supplement to pharmacotherapy. A thorough overview of the literature on psychoeducation for adult ADHD is lacking. The objectives of this scoping review were therefore to identify the characteristics of psychoeducation interventions designed for adults with ADHD, examine how the patient experience or perspective is considered during the intervention’s development and implementation, determine the typical themes covered, and explore how ‘psychoeducation’ is defined in these interventions. Methods A comprehensive search was performed to identify records in MEDLINE, Embase, PsycINFO, Web of Science, Cochrane CENTRAL, AMED, and ClinicalTrials.gov. Two or more reviewers were included in every step of the screening process and the final selection of included studies. The Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist (Supplementary Material 1) was used to report the results, and the framework developed by Arksey and O’Malley was used as a guide throughout the scoping process. Results A total of 2121 records were identified through the literature search. After screening and full-text analysis, ten studies were included for final analysis. Most studies were conducted in Europe and followed a group format. Seven main themes were identified: Information about the diagnosis, treatment options, somatic health and ADHD, the insider perspective, ADHD and social life, coping and psychological skills, and ADHD and work. There was significant overlap in themes covered, but coverage of each theme varied. Themes deemed important by newer research, such as sexuality and gender-specific issues, were missing. Only one intervention involved patients in its development and implementation, and two interventions involved family members. There was variation in how psychoeducation was defined in the included studies, and the implications of this are discussed. Conclusion The literature on psychoeducation for adult ADHD is not ready for any systematic effect estimation. Before such estimations are conducted, a shared understanding and definition of psychoeducation are needed. The involvement of end users in the development and delivery of interventions may aid reach this goal but results from this review indicate that such practices are rare.

show abstract

“…Impulsivity is a core symptom in ADHD and is associated with an increased risk for SUD, including alcoholism [26,27]. Cognitive impulsiveness (i.e.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Attention Deficit Hyperactivity Disorder and Severe Substance use Disorder in Adult Inpatients: A Cross-sectional Study

Calazans,

Moura,

Soares

et al. 2023

JAMMR

View full text Add to dashboard Cite

Objectives: To evaluate the frequency of Attention Deficit Hyperactivity Disorder (ADHD) in adults admitted for treatment of severe chemical dependence in the Therapeutic Community Rios de Água Viva in Coronel Fabriciano, Minas Gerais, Brazil. Method: A cross-sectional study with male subjects aged 18 years or older, compared to age-matched men without chemical dependence on a 1:1 ratio. Data collection was performed by applying a questionnaire with the Fifth Edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) of American Psychiatric Association criteria for diagnosis of ADHD, also information on demographic profile, smoking and age of onset of psychoactive chemical substance use. Results: Most patients have high school education (72.7%), are not married (93.2%) and are smokers (86.4%). From 44 patients with Substance Use Disorder who were screened for ADHD symptoms, 22.7% screened positive for the disorder, while only 2.3% of the control group received this diagnosis (p<0.001). The most used drug was alcohol (100%), followed by cocaine-crack (47%) and in third place cannabis (4.5%). Conclusion: Higher frequencies of ADHD symptoms were found among severe chemical dependents interned in Therapeutic Community.

show abstract

Lifetime evolution of ADHD treatment

Cited by 4 publications

References 140 publications

Modulation of Spatial Memory Deficit and Hyperactivity in Dopamine Transporter Knockout Rats via α2A-Adrenoceptors

Modulation of Spatial Memory Deficit and Hyperactivity in Dopamine Transporter Knockout Rats via α2A-Adrenoceptors

Psychoeducation for adult ADHD: a scoping review about characteristics, patient involvement, and content

Relationship between Attention Deficit Hyperactivity Disorder and Severe Substance use Disorder in Adult Inpatients: A Cross-sectional Study

Contact Info

Product

Resources

About