Lifetime Low-Level Exposure to Environmental Lead and Children's Emotional and Behavioral Development at Ages 11-13 Years: The Port Pirie Cohort Study

Burns, Jack; Baghurst, Peter; Sawyer, Michael; McMichael, Anthony J.; Tong, Shilu

doi:10.1093/oxfordjournals.aje.a009883

Cited by 143 publications

(94 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The significantly higher prevalence of behaviour problems and irritability in children with elevated lead levels is consistent with the reported association of lead exposure with behaviour problems, 31 antisocial and delinquent behaviour, 32 and destructive trends in preschool children.…”

supporting

confidence: 87%

Lead levels and cognitive abilities in Peruvian children

Vega‐Dienstmaier

Salinas-Piélago

Gutiérrez-Campos

et al. 2006

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Lead levels and cognitive abilities in Peruvian children Níveis de chumbo e funções cognitivas em crianças peruanas A b s t r a c t Objective: To study the relationship between blood lead levels and cognitive abilities of children exposed to this metal. Method: This is a cross-sectional study that included 134 children aged 6 to 8.5 years old from 3 schools with different risks of lead exposure located in El Callao (Peru Kohs (39,6% vs. 18,6%, p = 0,01), quando comparadas com aquelas com níveis séricos menores. Um déficit de uma categoria no Teste Gráfico de Raciocínio foi associado com um aumento no nível sérico de chumbo de 16,78 ug/dl (assumindo uma relação linear) e de 1 a 5,19 ug/dl (modelo logarítmico). Para cada 10 ug/dl de aumento no nível sérico de chumbo, o Teste dos Cubos de Kohs apresentou diminuição de 6,24 unidades (12,91 para os meninos e 0,216 para as meninas) (modelo linear) e um aumento de 1 a 10 ug/dl correspondeu a uma diminuição de 16,44 pontos no Teste dos Cubos de Kohs (31,19 para os meninos e 3,98 para as meninas) (modelo logarítmico). Considerando as subescalas do Teste Gráfico de Raciocínio, os níveis séricos de chumbo correlacionaram-se negativamente com as áreas de problemas numéricos (rho = -0,445, p < 0,001), relações numéricas (rho = -0,365, p < 0,001), inferências (rho = -0,281, p = 0,002) e semelhanças (rho = -0,250, p = 0,005). Conclusões: Níveis séricos de chumbo foram associados de uma maneira não-linear com déficits das habilidades cognitivas, especialmente entre os meninos, sendo o raciocínio numérico a área mais afetada.

show abstract

supporting

confidence: 87%

Lead levels and cognitive abilities in Peruvian children

Vega‐Dienstmaier

Salinas-Piélago

Gutiérrez-Campos

et al. 2006

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…Third, professional cleaning-which led to the largest reductions in blood lead concentration-is not available for most high-risk families in substandard housing. Finally, although there was evidence that dust control was efficacious in reducing children's blood lead concentrations, the adverse effects of undue lead exposure persist even after blood lead levels decline (35,36). Thus, from a societal perspective, it is unethical to rely on interventions that occur only after children are unduly exposed (12).…”

Section: Professional Dust Controlmentioning

confidence: 99%

The effect of interior lead hazard controls on children's blood lead concentrations: a systematic evaluation.

Haynes

Lanphear

Tohn

et al. 2002

Environ Health Perspect

View full text Add to dashboard Cite

Dust control is often recommended to prevent children's exposure to residential lead hazards, but the effect of these controls on children's blood lead concentrations is uncertain. We conducted a systematic review of randomized, controlled trials of low-cost, lead hazard control interventions to determine the effect of lead hazard control on children's blood lead concentration. Four trials met the inclusion criteria. We examined mean blood lead concentration and elevated blood lead concentrations (> or = 10 microg/dL, > or = 15 microg/dL, and > or = 20 microg/dL) and found no significant differences in mean change in blood lead concentration for children by random group assignment (children assigned to the intervention group compared with those assigned to the control group). We found no significant difference between the intervention and control groups in the percentage of children with blood lead > or = 10 microg/dL, 29% versus 32% [odds ratio (OR), 0.85; 95% confidence interval (CI), 0.56-1.3], but there was a significant difference in the percentage of children with blood lead > or = 15 microg/dL between the intervention and control groups, 6% versus 14% (OR, 0.40; 95% CI, 0.21-0.80) and in the percentage of children with blood lead > or = 20 microg/dL between the intervention and control groups, 2% versus 6% (OR, 0.29; 95% CI, 0.10-0.85). We conclude that although low-cost, interior lead hazard control was associated with 50% or greater reduction in the proportion of children who had blood lead concentrations exceeding 15 microg/dL and > or = 20 microg/dL, there was no substantial effect on mean blood lead concentration.

show abstract

“…[1][2][3] Even at very low doses, lead poisoning can cause developmental neuropsychological impairment. [4][5][6][7][8] Lead toxicity in children can result in poor cognitive performance, behavioral disturbance, learning disability, and low intellectual attainment. 9 In the United States, 1.7 million children younger than 6 years of age were estimated to have blood lead (PbB) levels greater than 10 µg/dL in 1998-1991.…”

mentioning

confidence: 99%