Lifetime physical inactivity is associated with increased risk for Hodgkin and non-Hodgkin lymphoma: A case-control study

Etter, John Lewis; Cannioto, Rikki A.; Soh, Kah Teong; Alquassim, Emad; Almohanna, Hani; Dunbar, Zachary R.; Joseph, Janine M.; Balderman, Sophia R.; Hernandez‐Ilizaliturri, Francisco J.; Moysich, Kirsten B.

doi:10.1016/j.leukres.2018.03.014

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…After title and abstract screening, 113 studies were identified for full text review including those identified on review of prior meta-analyses [10,14,21]. Final analysis included 18 studies-9 cohort [17,18,[22][23][24][25][26][27][28] and 9 case-control [15,16,[29][30][31][32][33][34][35], reporting a total of 12,053 new lymphoma cases. Study characteristics are summarized in Table 1.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

“…This meta-analysis expands on prior work [ 5 , 10 , 14 ] by incorporating two case-control [ 15 , 16 ] and two cohort studies [ 17 , 18 ] with 1432 additional lymphoma cases that have since been published, increasing case sample size by approximately 12%. In addition, within previous efforts [ 10 ] the outcome key words of “(lymphoma OR Hodgkin)” were likely satisfactory, however the exposure keywords may have missed studies examining specific forms of activity leading to incomplete evaluation which require further examination in subgroup or sensitivity analyses.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between physical activity and lymphoma: a systematic review and meta analysis

Davies

Strader²,

Chibbar

et al. 2020

BMC Cancer

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Background The literature suggests an increased risk between anthropometrics including higher body mass index and lymphoma incidence; however, the association with physical activity remains unclear. A systematic review/meta-analysis was therefore performed to examine this association with physical activity (total, recreational or occupational). Methods PubMed, Web of Science and Embase were reviewed from inception to October 2019 identifying relevant observational studies. Non-Hodgkin lymphoma (NHL) including subtypes diffuse large B cell lymphoma, follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, and Hodgkin lymphoma (HL) were analyzed. Included studies reported activity, lymphoma cases, effect size and variability measures, and were restricted to human subjects of any age. Data was pooled generating summary relative risk (RR) estimates with 95% confidence intervals (CI) using random-effects models with primary outcome of histologically confirmed incident lymphoma. Results One thousand four hundred studies were initially identified with 18 studies (nine cohort, nine case-control) included in final analysis. Comparing highest vs. lowest activity categories was protective for all lymphoma (RR 0.89, 95%CI 0.81–0.98). Sensitivity analysis demonstrated effect persistence within case-control studies (RR 0.82, 95% CI 0.71–0.96), but not cohort studies (RR 0.95, 95%CI 0.84–1.07). Borderline protective effect was seen for NHL (RR 0.92, 95%CI 0.84–1.00), but not HL (RR 0.72, 95%CI 0.50–1.04). Analysis by NHL subtype or gender showed no effect. Dose response analysis demonstrated a protective effect (p = 0.034) with a 1% risk reduction per 3 MET hours/week (RR 0.99, 95%CI 0.98–1.00). Conclusions Physical activity may have a protective effect against lymphoma development; further studies are required to generate recommendations regarding health policy. Trial registration This study was registered prospectively at PROSPERO: CRD42020156242.

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Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The relationship between physical activity and lymphoma: a systematic review and meta analysis

Davies

Strader²,

Chibbar

et al. 2020

BMC Cancer

View full text Add to dashboard Cite

show abstract

“…[36,37] Obesity and high birth weight have also been shown to be associated with an increased chance of developing HL. [38][39][40][41] Specifically, high intake of sweets and meat, as well as limited physical activity have also been found to contribute to the development of HL. [42] The risk of developing HL, especially mixed cellularity and nodular sclerosis classic HL, increases with a positive history of eversmoking.…”

Section: Lymphoma Epidemiologymentioning

confidence: 99%

Therapeutic potentials of melatonin in the treatment of lymphoma: A review of current evidence

Moradian

Pourhanifeh

Mehrzadi

et al. 2022

Fundamemntal Clinical Pharma

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Hematological malignancies including leukemia, multiple myeloma, and lymphoma are known as leading causes of death around the world. Despite all developments in cancer management, current therapeutic methods are still relatively inefficient, leading to the heavy financial burdens for public health systems. Strategic attempts in clinical practice must be based on three serious goals including (1) increasing the efficacy of treatments and decreasing their side-effects; (2) decreasing financial price of treatments and related morbidity and mortality rates; and (3) improving life quality and survival of affected patients. Melatonin, a multipotential neurohormone mainly secreted by the pineal gland, has recently been shown to play essential roles in the treatment of various human diseases. Moreover, it possesses anticancer impacts and acts through regulation of underlying cellular and molecular mechanisms. In this article, we review mechanistic roles and beneficial effects of melatonin against hematological cancers, especially lymphoma.

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Hodgkin Disease

Poggi¹

2020

Encyclopedia of Life Sciences

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Hodgkin disease is a malignancy of the lymphatic system, affecting predominantly young adults. Radio and chemotherapy have allowed long‐term cure in a large portion of patients. Unfortunately, 15–20% of patients can relapse and eventually die to this disease. CD30+ Reed–Sternberg cells represent the hallmark of this disease and they can be a variable, but usually very small portion of the cellular components of the affected lymph nodes. On the other hand, it is prominent the presence of a tumour microenvironment composed of nonmalignant B cells, T cells, granulocytes, eosinophils and stromal cells. It is thought that this microenvironment can influence the fate of the lymphoma cell growth and finally the clinical outcome of this disease. Recent therapeutic approaches such as chimeric anti‐CD30 antibody‐drug conjugates, chimeric antigen receptor T cells to the CD30 surface molecule and immune checkpoint inhibitors have given a new hope to treat patients with a relapsed/refractory disease. Key Concept Reed–Sternberg cells expressing CD30 membrane surface molecule are the main feature of the Hodgkin disease. Reed–Sternberg cells induce a strong immunosuppressive tumour microenvironment. Fluorodeoxyglucose (FDG) positron emission tomography (PET)–computerised tomography (CT) is essential to define the Hodgkin disease stage and the response to therapy. Combination chemotherapy with ABVD or MOPP followed by X‐ray radiation is the standard treatment for Hodgkin disease. 15–20% of Hodgkin disease patients do not respond to the combination chemotherapy and radiation or can relapse. The salvage therapy consists of high‐dose combination chemotherapy followed by autologous or allogeneic hematopoietic stem‐cell transplantation. Relapsed/refractory patients can be treated with anti‐CD30 drug‐conjugated antibodies or anti‐CD30 chimeric antigen receptor T cells or immune checkpoint inhibitors. Immune checkpoint inhibitors are antibodies to molecules involved in the regulation of immune response.

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Lifetime physical inactivity is associated with increased risk for Hodgkin and non-Hodgkin lymphoma: A case-control study

Cited by 7 publications

References 26 publications

The relationship between physical activity and lymphoma: a systematic review and meta analysis

The relationship between physical activity and lymphoma: a systematic review and meta analysis

Therapeutic potentials of melatonin in the treatment of lymphoma: A review of current evidence

Hodgkin Disease

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