Lifetime prevalence and co-morbidity of externalizing disorders and depression in prospective assessment

Hamdi, Nayla R.; Iacono, William G.

doi:10.1017/s0033291713000627

Cited by 41 publications

(29 citation statements)

References 26 publications

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“…The high concordance between self- and co-twin reports, the development of the CUD diagnosis via consensus, and the longitudinal repetition of the collection of diagnostic data (Hamdi & Iacono 2014) further validates of the empirically-derived cannabis groups. In particular, differences between the CUD and non-CUD users does not seem to be due to either an unwillingness to report symptoms or a lack of insight into CUD symptoms in the latter group.…”

Section: Discussionmentioning

confidence: 71%

“…User groups (CUD users and non-CUD users) were first compared to one another and then each was compared to a third group of individuals who reported no use of cannabis at any of the assessments (non-users, n = 996). Longitudinal assessment of drug use and symptoms has been shown to yield more accurate estimates of lifetime prevalence rates of frequent cannabis use and CUD than a cross-sectional approach to defining groups at a single time point (Hamdi & Iacono 2014). …”

Section: Methodsmentioning

confidence: 99%

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Psychosocial functioning among regular cannabis users with and without cannabis use disorder

et al. 2017

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BACKGROUND In the United States, cannabis accessibility has continued to rise as the perception of its harmfulness has decreased. Only about 30% of regular cannabis users develop cannabis use disorder (CUD), but it is unclear if individuals who use cannabis regularly without ever developing CUD experience notable psychosocial impairment across the lifespan. Therefore, psychosocial functioning was compared across regular cannabis users with or without CUD and a non-user control group during adolescence (age 17; early risk) and young adulthood (ages 18–25; peak CUD prevalence). METHOD Weekly cannabis users with CUD (n = 311), weekly users without CUD (n = 111), and non-users (n = 996) were identified in the Minnesota Twin Family Study. Groups were compared on alcohol and illicit drug use, psychiatric problems, personality, and social functioning at age 17 and from ages 18 to 25. Self-reported cannabis use and problem use were independently verified using co-twin informant report. RESULTS In both adolescence and young adulthood, non-CUD users reported significantly higher levels of substance use problems and externalizing behaviors than non-users, but lower levels than CUD users. High agreement between self- and co-twin informant reports confirmed the validity of self-reported cannabis use problems. CONCLUSIONS Even in the absence of CUD, regular cannabis use was associated with psychosocial impairment in adolescence and young adulthood. However, regular users with CUD endorsed especially high psychiatric comorbidity and psychosocial impairment. The need for early prevention and intervention - regardless of CUD status - was highlighted by the presence of these patterns in adolescence.

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Section: Discussionmentioning

confidence: 71%

Section: Methodsmentioning

confidence: 99%

Psychosocial functioning among regular cannabis users with and without cannabis use disorder

et al. 2017

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“…However, since free and non-specific binding account for only 15% of MAO-A V T , differences in the measure primarily reflect changes in specific MAO-A binding . Finally, similar to the overwhelming majority of studies of ASPD and violent offenders, our sample was limited to males, which may be justified on the basis that ASPD is 5-7 times more common in men than women (Hamdi and Iacono, 2014).…”

Section: Discussionmentioning

confidence: 99%

Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [11C] Harmine Positron Emission Tomography Study

Kolla

Matthews

Wilson

et al. 2015

Neuropsychopharmacol

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Antisocial personality disorder (ASPD) often presents with highly impulsive, violent behavior, and pathological changes in the orbitofrontal cortex (OFC) and ventral striatum (VS) are implicated. Several compelling reasons support a relationship between low monoamine oxidase-A (MAO-A), an enzyme that regulates neurotransmitters, and ASPD. These include MAO-A knockout models in rodents evidencing impulsive aggression and positron emission tomography (PET) studies of healthy subjects reporting associations between low brain MAO-A levels and greater impulsivity or aggression. However, a fundamental gap in the literature is that it is unknown whether brain MAO-A levels are low in more severe, clinical disorders of impulsivity, such as ASPD. To address this issue, we applied [(11)C] harmine PET to measure MAO-A total distribution volume (MAO-A VT), an index of MAO-A density, in 18 male ASPD participants and 18 age- and sex-matched controls. OFC and VS MAO-A VT were lower in ASPD compared with controls (multivariate analysis of variance (MANOVA): F2,33=6.8, P=0.003; OFC and VS MAO-A VT each lower by 19%). Similar effects were observed in other brain regions: prefrontal cortex, anterior cingulate cortex, dorsal putamen, thalamus, hippocampus, and midbrain (MANOVA: F7,28=2.7, P=0.029). In ASPD, VS MAO-A VT was consistently negatively correlated with self-report and behavioral measures of impulsivity (r=-0.50 to -0.52, all P-values<0.05). This study is the first to demonstrate lower brain MAO-A levels in ASPD. Our results support an important extension of preclinical models of impulsive aggression into a human disorder marked by pathological aggression and impulsivity.

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“…The National Comorbidity Survey Replication (NCS-R), an epidemiological survey that assessed diagnoses of common psychiatric disorders using retrospective, cross-sectional assessment, found a lifetime prevalence estimate of 16.6% for MDD (Kessler, Berglund et al, 2005). Recent prospective, longitudinal studies suggest that MDD may be even more common, with lifetime prevalence estimates through early-to-middle adulthood ranging from 26.0% to 54.8% (Beesdo et al, 2009; Hamdi & Iacono, 2014; Moffitt et al, 2010; Olino et al, 2012). For many individuals, depressive disorders emerge well before adulthood—the 3- to 12-month prevalence estimate is relatively low at 2.8% for children under age 13, but the estimate for MDD of 5.7% for adolescents aged 13 to 18 (Costello, Erkanli, & Angold, 2006) is comparable to the 12-month estimate of 6.7% for adults (Kessler, Chiu, Demler, Merikangas, & Walters, 2005).…”

mentioning

confidence: 99%

Premorbid risk factors for major depressive disorder: Are they associated with early onset and recurrent course?

et al. 2014

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Premorbid risk for major depressive disorder (MDD) and predictors of an earlier onset and recurrent course were examined in two studies in a large, community-based sample of parents and offspring, prospectively assessed from late childhood into adulthood. In Study 1 (N = 2,764 offspring and their parents), parental psychiatric status, offspring personality at age 11, and age-11 offspring internalizing and externalizing symptoms predicted the subsequent development of MDD, as did poor quality parent-child relationships, poor academic functioning, early pubertal development, and childhood maltreatment by age 11. Parental MDD and adult antisocial behavior, offspring negative emotionality and disconstraint, externalizing symptoms, and childhood maltreatment predicted an earlier onset of MDD, after accounting for course; lower positive emotionality, trait anxiety, and childhood maltreatment predicted recurrent MDD, after accounting for age of onset. In Study 2 (N = 7,146), we examined molecular genetic risk for MDD by extending recent reports of associations with glutamatergic system genes. We failed to confirm associations with MDD using either individual SNP-based tests or gene-based analyses. Overall, results speak to the pervasiveness of risk for MDD, as well as specific risk for early-onset MDD; risk for recurrent MDD appears to be largely a function of its often earlier onset.

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Lifetime prevalence and co-morbidity of externalizing disorders and depression in prospective assessment

Cited by 41 publications

References 26 publications

Psychosocial functioning among regular cannabis users with and without cannabis use disorder

Psychosocial functioning among regular cannabis users with and without cannabis use disorder

Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [11C] Harmine Positron Emission Tomography Study

Premorbid risk factors for major depressive disorder: Are they associated with early onset and recurrent course?

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