Lifetime Prevalence of Congenital Heart Disease in the General Population From 2000 to 2010

Abstract

Background-Our objective was to obtain contemporary lifetime estimates of congenital heart disease (CHD) prevalence using population-based data sources up to year 2010. Methods and Results-The Quebec CHD database contains 28 years of longitudinal data on all individuals with CHD from 1983 to 2010. Severe CHD was defined as tetralogy of Fallot, truncus arteriosus, transposition complexes, endocardial cushion defects, and univentricular hearts. We used latent class bayesian models combining case definitions from physician claims, hospitalization, and surgical data to obtain point and interval prevalence estimates of CHD in the first year of life, in children (<18 years of age) and in adults. We identified 107 559 CHD patients from 1983 to 2010. Prevalence of CHD in the first year of life was 8.21 per 1000 live births (95% confidence interval, 7.47-9.02) from 1998 to 2005. In 2010, overall prevalence of CHD was 13.11 per 1000 (95% confidence interval, 12.43-13.81) in children and 6.12 per 1000 (95% confidence interval, 5.69-6.57) in adults. CHD prevalence increased by 11% in children and 57% in adults from 2000 to 2010. Prevalence in the severe CHD subgroup increased by 19% (95% confidence interval, 17%-21%) in children and 55% (51%-62%) in adults. By 2010, adults accounted for 66% of the entire CHD population. Conclusions-With

Adult Congenital Heart Disease in a Nationwide Population 2000–2014: Epidemiological Trends, Arrhythmia, and Standardized Mortality Ratio

“…Such an increase might continue until the prevalence is close to the incidence of CHD at birth adjusted by optimized survival. In 2014, the prevalence of ACHD in our study was 2.17 per 1000 adults, which is within the previous reported estimated range (1.7–6.12 per 1000) 1, 3, 4, 5, 6. In most high‐income countries in which care for ACHD is increasingly structured, prevalence of severe ACHD would increase over time 3, 4, 11.…”

“…Open heart surgery for CHD was first performed in the 1940s in North America. According to administrative database, prevalence of ACHD in Quebec was 4.09 per 1000 adults in 2000 and 6.12 per 1000 adults in 2011 3, 4. Data of ACHD prevalence may also be estimated from CHD incidence at birth and survival estimate for each type of CHD.…”

Genetics and Genetic Testing in Congenital Heart Disease

“…Contemporary advancements in medical care, surgical interventions, and diagnostics have contributed to a well-characterized decrease in patient mortality and concomitant increase in CHD prevalence among patients of reproductive age [38][39][40] . Recent analyses indicate that adults now constitute roughly two-thirds of the CHD population, representing a nearly 60% increase in CHD prevalence among adult patients since the year 2000 38 .…”

“…Recent analyses indicate that adults now constitute roughly two-thirds of the CHD population, representing a nearly 60% increase in CHD prevalence among adult patients since the year 2000 38 . The fact that the greatest increase in CHD prevalence has occurred among the 18-to 40-year-old demographic 38 has clear implications for heritability.…”

Extra-cardiac manifestations of adult congenital heart disease

“…Palliative or corrective interventions are now available for nearly every type of congenital cardiac lesion, and approximately 90% of affected children now survive to adulthood [1]. Adults with CHD (ACHD) already outnumber pediatric CHD patients, and this population is expected to grow by 5% per year [1,2]. Strikingly, the median age of severe CHD patients has increased from 11 years in 1985 to 25 years in 2010 [3].…”