Lifetime Risk of CKD

Delanaye, Pierre; Glassock, Richard J.

doi:10.2215/cjn.07860715

Cited by 9 publications

(6 citation statements)

References 24 publications

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“… 3 4 Lower nephron number has been associated with the development of hypertension and progressive kidney disease later in life. 5 6 7 8 We hypothesized that preterm birth, through its effects on lower nephron endowment, leads to a persistent increased risk of chronic kidney disease (CKD) into adulthood.…”

Section: Introductionmentioning

confidence: 99%

Preterm birth and risk of chronic kidney disease from childhood into mid-adulthood: national cohort study

Crump

Sundquist

Winkleby

et al. 2019

BMJ

183

130

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Objective To investigate the relation between preterm birth (gestational age <37 weeks) and risk of CKD from childhood into mid-adulthood. Design National cohort study. Setting Sweden. Participants 4 186 615 singleton live births in Sweden during 1973-2014. Exposures Gestational age at birth, identified from nationwide birth records in the Swedish birth registry. Main outcome measures CKD, identified from nationwide inpatient and outpatient diagnoses through 2015 (maximum age 43 years). Cox regression was used to examine gestational age at birth and risk of CKD while adjusting for potential confounders, and co-sibling analyses assessed the influence of unmeasured shared familial (genetic or environmental) factors. Results 4305 (0.1%) participants had a diagnosis of CKD during 87.0 million person years of follow-up. Preterm birth and extremely preterm birth (<28 weeks) were associated with nearly twofold and threefold risks of CKD, respectively, from birth into mid-adulthood (adjusted hazard ratio 1.94, 95% confidence interval 1.74 to 2.16; P<0.001; 3.01, 1.67 to 5.45; P<0.001). An increased risk was observed even among those born at early term (37-38 weeks) (1.30, 1.20 to 1.40; P<0.001). The association between preterm birth and CKD was strongest at ages 0-9 years (5.09, 4.11 to 6.31; P<0.001), then weakened but remained increased at ages 10-19 years (1.97, 1.57 to 2.49; P<0.001) and 20-43 years (1.34, 1.15 to 1.57; P<0.001). These associations affected both males and females and did not seem to be related to shared genetic or environmental factors in families. Conclusions Preterm and early term birth are strong risk factors for the development of CKD from childhood into mid-adulthood. People born prematurely need long term follow-up for monitoring and preventive actions to preserve renal function across the life course.

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Section: Introductionmentioning

confidence: 99%

Preterm birth and risk of chronic kidney disease from childhood into mid-adulthood: national cohort study

Crump

Sundquist

Winkleby

et al. 2019

BMJ

183

130

View full text Add to dashboard Cite

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“…We must keep in mind that the period of time between two consecutive measurements was also variable, but basically much longer (3–7 years) than the 3-month period required in the KDIGO definition [22]. The conclusions of this article must thus be interpreted with caution regarding the purpose of the current editorial, but these results perfectly illustrate that using a single eGFR result will lead to a significantly higher prevalence of CKD [22, 23]. …”

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confidence: 99%

Epidemiology of chronic kidney disease: think (at least) twice!

Delanaye

Glassock²,

Broe

2017

Clinical Kidney Journal

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The introduction of the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines has substantially contributed to the early detection of different stages of chronic kidney disease (CKD). Several recent studies from different parts of the world mention a CKD prevalence of between 8 and 13%. There are several reasons the CKD prevalence found in a study of a particular population is clearly overestimated. The structure of the population pyramid (young or older age) of the study sample may result in high or low CKD prevalence. The absence of using an isotope dilution mass spectrometry creatinine assay can be the source of high bias in CKD prevalence. In addition, using an arbitrary single threshold of estimated glomerular filtration rate (eGFR; <60 mL/min/1.73 m2) for classifying CKD leads to a substantial ‘overdiagnosis’ (false positives) in the elderly (>65 years of age), particularly in those without albuminuria (or proteinuria), haematuria or hypertension. It also results in a significant ‘underdiagnosis’ (false negatives) in younger individuals with an eGFR >60 mL/min/1.73 m2 and below the third percentile for their age/gender category. The use of third percentile eGFR rates as a cut-off based on age/gender-specific reference values of eGFR allows the detection of these false positives and negatives. In the present article, we focus on an important and frequently omitted criterion in epidemiological studies: chronicity. Indeed, the two most important factors introducing a high number (up to 50%) of false positives are lack of confirming proteinuria and the absence of proof of chronicity of the eGFR found at first screening. There is an urgent need for quality studies of the prevalence of CKD using representative randomized samples of the population, applying the KDIGO guidelines correctly.

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“…However, the KDIGO criteria that define CKD are a subject of a very intense debate in the current nephrology literature, with recommendations for the introduction of an age-specific limit for GFR. [ 23 24 25 26 ]…”

Section: Discussionmentioning

confidence: 99%

Serum Creatinine versus Corrected Cockcroft-Gault Equation According to Poggio Reference Values in Patients with Arterial Hypertension

Šečić¹,

Turohan²,

Begić³

et al. 2022

International Journal of Applied &Amp; Basic Medical Research

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Introduction: Serum creatinine is not enough sensitive marker for the evaluation of glomerular filtration rate (GFR). Cockcroft-Gault (CG) formula is often used to assess GFR, but it is necessary to correct original one for body surface area (BSA), adipositas, and the creatinine tubular secretion. The values of the estimated creatinine clearance and GFR are considered to Poggio reference ones according to biological parameters (age and gender). The aim of the study was to determine the difference in renal function estimation between serum creatinine and corrected CG equation according to the Poggio reference values in the arterial hypertension patients. Materials and Methods: The research included 124 patients of both gender with arterial hypertension, excluding ones with the already verified chronic kidney disease. We estimated creatinine clearance and GFR by CG method corrected for the BSA, body mass index (BMI), and the creatinine tubular secretion according to Poggio reference values. Results: There was no significant difference in both age and gender groups among patients with physiological and pathological values of the renal function determined by the serum creatinine and estimated creatinine clearance by CG equation corrected for BMI, BSA. In both age and gender groups there was significant difference among subjects with physiological and pathological values of the renal function determined by serum creatinine and estimated GFR by CG method corrected for BMI, BSA, and creatinine tubular secretion. Conclusion: There is the most striking difference in the assessment of renal function between serum creatinine and estimated GFR by CG method with three corrections (BSA, BMI, the creatinine tubular secretion). Estimated GFR by CG method with three corrections can help in the early diagnosis of renal dysfunction and optimal treatment in patients with arterial hypertension.

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Lifetime Risk of CKD

Cited by 9 publications

References 24 publications

Preterm birth and risk of chronic kidney disease from childhood into mid-adulthood: national cohort study

Preterm birth and risk of chronic kidney disease from childhood into mid-adulthood: national cohort study

Epidemiology of chronic kidney disease: think (at least) twice!

Serum Creatinine versus Corrected Cockcroft-Gault Equation According to Poggio Reference Values in Patients with Arterial Hypertension

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