LIFRα-CT3 induces differentiation of a human acute myelogenous leukemia cell line HL-60 by suppressing miR-155 expression through the JAK/STAT Pathway

DNA Methylation Regulates Gene Expression in Intracranial Aneurysms

“…20 Moreover, the alpha chain of the leukemia inhibitory factor receptor (LIFRα-CT3) and its fusion protein (TAT-CT3) can induce the phosphorylation of STAT3. 21 In this study, the methylation of LIFR at site …”

miR‐155 promotes macrophage pyroptosis induced by Porphyromonas gingivalis through regulating the NLRP3 inflammasome

“…Therefore, we deduced that miR-155 indirectly regulates the inflammasome and pyroptosis in macrophages. Several studies found that miR-155 downregulates SOCS1 expression (Cardoso, Guedes, Pereira de Almeida, & Pedroso de Lima, 2012;Wang et al, 2016), and SOCS1 inhibits the macrophage inflammatory response by regulating the JAK/STAT pathway (Xu et al, 2014) and promotes the transformation from pro-caspase-11 to caspase-11 (Schauvliege, Vanrobaeys, Schotte, & Beyaert, 2002), which increases NLRP3 expression (Rathinam et al, 2012) and eventually promotes pyroptosis in macrophages. The results in this study showed that SOCS1 expression increased, while caspase-11, caspase-1, NLRP3, GSDMD-NT, IL-1β, and IL-18 expression decreased in miR-155silenced macrophages stimulated with P. gingivalis.…”

microRNA-146a Promotes Growth of Acute Leukemia Cells by Downregulating Ciliary Neurotrophic Factor Receptor and Activating JAK2/STAT3 Signaling

“…In addition, miR-147 could regulate the JAK/STAT signaling pathway in myeloid leukemia 33. Some studies have indicated that LIFRα cytoplasmic domain could induce differentiation of the AML cell line HL-60 by inhibiting miR-155 expression through JAK/STAT signaling 34. A study of Ip, et al12 revealed that miR-708 could exert oncogenic effects in leukemia via regulating CNTFR and activating JAK/STAT pathway.…”